【摘要】：目的本實驗通過對維生素D治療前后支氣管哮喘患兒血清25-(OH)D水平的檢測,觀察25-(OH)D水平在哮喘患兒體內(nèi)的變化;探討維生素D與兒童支氣管哮喘之間的關系,為小兒支氣管哮喘的防治尋求新的治療靶點和臨床方法。方法選取2015年9月--2016年9月在延安大學附屬醫(yī)院兒科就診的支氣管哮喘患兒98例,將98例哮喘患兒隨機分為兩組:即實驗組(維生素D治療組)和觀察組(非維生素D治療組);兩組患兒(有急性發(fā)作的待急性癥狀控制后)均給與控制癥狀等哮喘規(guī)范化治療,實驗組(維生素D治療組)患兒除常規(guī)治療外,給予補充維生素D(800iu/日)治療3個月;同時隨機抽取來我院體檢的健康兒童50例作為對照組,治療前后分別測定實驗組(維生素D治療組)和觀察組(非維生素D治療組)兩組患兒血清25-(OH)D水平;對照組(健康兒童)在入院體檢時用同樣方法檢測血清25-(OH)D水平,觀察記錄實驗組(維生素D治療組)和觀察組(非維生素D治療組)兩組患兒的哮喘控制情況。結果1.支氣管哮喘患兒血清25-(OH)D水平比正常健康兒童降低,兩組間差異具有統(tǒng)計學意義(P0.05)。2.治療前實驗組(維生素D治療組)和觀察組(非維生素D治療組)兩組患兒血清25-(OH)D水平差別不明顯,差異無統(tǒng)計學意義(P0.05);治療后實驗組(維生素D治療組)和觀察組(非維生素D治療組)患兒血清25-(OH)D水平都較治療前升高,實驗組(維生素D治療組)較觀察組(非維生素D治療組)組升高明顯,兩組差異具有統(tǒng)計學意義(P0.05)。3.實驗組(維生素D治療組)和觀察組(非維生素D治療組)治療后血清25-(OH)D水平較治療前升高,實驗組(維生素D治療組)升高幅度大,但和對照組(健康兒童)相比仍有差異,具有統(tǒng)計學意義(P0.05)4.實驗組(維生素D治療組)在治療中給予補充一定劑量的維生素D后,實驗組(維生素D治療組)較觀察組(非維生素D治療組)控制率升高,兩組之間比較差異有統(tǒng)計學意義(P0.05)。結論1.維生素D在兒童支氣管哮喘的發(fā)生、發(fā)展中起著一定的作用;維生素D缺乏或不足可能是哮喘的發(fā)病因素之一。2.支氣管哮喘患兒血清維生素D水平明顯低于健康兒童,對哮喘患兒進行補充維生素D治療后,患兒的哮喘控制情況明顯好轉。3.維生素D可能對小兒支氣管哮喘的預防、控制起著積極的作用。
[Abstract]:Objective To observe the serum level of 25- (OH) D in children with bronchial asthma before and after vitamin D treatment, observe the changes of 25- (OH) D level in children with asthma, explore the relationship between vitamin D and bronchial asthma in children, and seek new therapeutic targets and clinical methods for the prevention and treatment of bronchial asthma in children. Methods selected in 2015 9 In September, --2016, 98 children with bronchial asthma in Affiliated Hospital of Yan'an University, 98 children with asthma were randomly divided into two groups: the experimental group (vitamin D treatment group) and the observation group (non vitamin D treatment group), and the two groups of children (after acute attack to acute disease control) were all given standardized treatment of asthma control, such as control symptoms. The group (vitamin D treatment group) was treated with vitamin D (800iu/ day) for 3 months, and 50 healthy children in our hospital were randomly selected as the control group. The serum 25- (OH) D levels of the experimental group (vitamin D treatment group) and the observation group (non vitamin D treatment group) were measured before and after treatment, and the control group was compared with the control group. Group (healthy children) detected the serum 25- (OH) D level by the same method at admission, observed the control of asthma in the two groups of the experimental group (vitamin D treatment group) and the observation group (non vitamin D treatment group). Results the serum 25- (OH) D level of the children with 1. bronchial asthma was lower than that of the normal healthy children. The difference between the two groups was statistically significant. There was no significant difference in serum 25- (OH) D level between the two groups of the experimental group (vitamin D treatment group) and the observation group (non vitamin D treatment group). The serum 25- (OH) levels in the experimental group (vitamin D treatment group) and the observation group (non vitamin D treatment group) were all higher than before the treatment, and the experimental group was higher than before treatment, and the experimental group was higher than before treatment, and the experimental group was higher than before treatment, the experiment was higher than before treatment, the experiment was higher than before treatment. Group (vitamin D treatment group) was significantly higher than that in the observation group (non vitamin D treatment group), the difference between the two groups was statistically significant (P0.05).3. experimental group (vitamin D treatment group) and the observation group (non vitamin D treatment group) after treatment, the serum 25- (OH) D level was higher than before the treatment, the experimental group (vitamin D treatment group) increased significantly, but the control group (healthy) Kang Ertong) compared with the difference, with statistical significance (P0.05) 4. experimental group (vitamin D treatment group) supplemented with a certain dose of vitamin D in the treatment group (vitamin D treatment group) compared with the observation group (non vitamin D treatment group) control rate increased, the difference between the two groups was statistically significant (P0.05). Conclusion 1. vitamin D in children The development of child bronchial asthma plays a role in the development of a certain role. Vitamin D deficiency or deficiency may be one of the factors of asthma. Serum vitamin D levels in children with bronchial asthma are obviously lower than those of healthy children. After supplementing vitamin D for children with asthma, the control of asthma in children is obviously better than that of.3. vitamin D, and the possibility of vitamin D is possible. Prevention and control of bronchial asthma play a positive role in children.
【學位授予單位】：延安大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R725.6

【參考文獻】

相關期刊論文 前10條

1 楊奕輝;;兒童肺炎型哮喘誤診分析[J];臨床誤診誤治;2016年05期

2 袁穎志;賀宇彤;吳成;張蕊;劉江惠;;Th1/Th2/Th17/Treg對鑒別兒童支氣管哮喘與單純性肺炎的意義[J];河北醫(yī)藥;2016年09期

3 高改蘭;李杰;湯淑斌;李維娜;楊艷;潘建平;;寶雞地區(qū)1874例0～7歲兒童維生素D水平調(diào)查研究[J];中國兒童保健雜志;2016年01期

4 石明;唐友勇;楊中衛(wèi);李威;王正艷;袁美春;;布地奈德福莫特羅對支氣管擴張癥合并支氣管哮喘患者肺功能及生活質量的影響[J];中國醫(yī)藥;2015年11期

5 孟珊珊;于金燕;閆冰迪;張慶華;王珂;張捷;劉晶;;哮喘患者調(diào)節(jié)性T細胞對Th1和Th2細胞的影響[J];中華實用診斷與治療雜志;2015年08期

6 王鵬程;張曉;;布地奈德沙丁胺醇聯(lián)合異丙托溴銨霧化吸入治療支氣管哮喘急性發(fā)作臨床效果觀察[J];河北醫(yī)學;2015年07期

7 聶揚;劉曉燕;鄧艷瓊;魏兵;李罡;;沙丁胺醇霧化吸入輔助治療小兒支氣管哮喘急性發(fā)作的療效觀察[J];現(xiàn)代生物醫(yī)學進展;2015年19期

8 莫麗亞;鄧永超;黃彩芝;劉健龍;;維生素D受體基因多態(tài)性與兒童哮喘相關性研究[J];中國兒童保健雜志;2015年07期

9 章建偉;王卓英;;0～9歲兒童維生素D水平的調(diào)查[J];浙江預防醫(yī)學;2015年03期

10 李春雨;徐乃軍;;維生素D的缺乏與兒童相關疾病[J];中國婦幼保健;2015年06期

相關會議論文 前1條

1 吳光馳;;我國人群維生素D營養(yǎng)狀況[A];婦幼與青少年營養(yǎng)進展學術研討會及《中國孕婦、乳母和0-6歲兒童膳食指南》宣傳推廣會論文匯編[C];2009年

，

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