【摘要】：目的分析輪狀病毒感染患兒的臨床特征及相關因素,為臨床診療提供指導依據(jù)。方法選取2015年1月-2016年12月來醫(yī)院就診的200例腹瀉患兒,采用免疫層析膠體金法進行輪狀病毒檢測,觀察輪狀病毒的感染情況,流行發(fā)病時間、患兒易感年齡、臨床特征及血清白細胞介素-2(IL-2)、白細胞介素-6(IL-6)、腫瘤壞死因子(TNF)、干擾素(INF-α)情況;同時搜集患兒的病例資料,單因素統(tǒng)計分析發(fā)生輪狀病毒感染的相關因素,進一步行多因素回歸分析引發(fā)感染的高危因素。結果 200例急性腹瀉患兒共檢出51例輪狀病毒,檢出率為25.5%;各月齡組患兒的輪狀病毒檢出率比較,差異有統(tǒng)計學意義(P0.05),其中以6~12月齡患兒的輪狀病毒檢出率較高;患兒的輪狀病毒感染在各季節(jié)的檢出率比較,差異有統(tǒng)計學意義(P0.05),其中以秋、冬季節(jié)檢出率較高,分別為39.5%和46.3%;輪狀病毒感染患兒在不同性狀樣便的陽性檢出率比較,差異有統(tǒng)計學意義(P0.05),其中在蛋花湯樣腹瀉患兒的陽性檢出率最高,達47.9%;輪狀病毒感染患兒的血清IL-2、IL-6、TNF、INF-α表達水平均顯著高于非感染組患兒,差異均有統(tǒng)計學意義(P0.05);單因素分析結果顯示,母乳喂養(yǎng)、患兒挑食、患兒手衛(wèi)生、住院時間15d、侵入性檢查、抗菌藥物連續(xù)應用1周及應用腸道微生態(tài)制劑與患兒發(fā)生輪狀病毒感染具有相關性(P0.05);非條件logistic多元素回歸分析結果顯示,采用母乳喂養(yǎng)、住院時間15d、抗菌藥物連續(xù)應用1周、應用腸道微生態(tài)制劑是輪狀病毒感染的獨立危險因素。結論輪狀病毒在急性腹瀉患兒糞便中檢出率較高,月齡在6~12個月、秋冬季節(jié)、大便性狀為蛋花湯樣檢出率最高;母乳喂養(yǎng)、住院時間15d、抗菌藥物連續(xù)應用1周及應用腸道微生態(tài)制劑與輪狀病毒感染密切相關。
[Abstract]:Objective to analyze the clinical characteristics and related factors of rotavirus infection in children and to provide guidance for clinical diagnosis and treatment. Methods 200 children with diarrhea from January 2015 to December 2016 were selected for rotavirus detection by immunochromatographic colloidal gold method. The infection of rotavirus, the time of onset of rotavirus, and the susceptible age of the children were observed. Clinical features and serum levels of interleukin-2 (IL-2), interleukin-6 (IL-6) and tumor necrosis factor (TNF), interferon (INF- 偽) were collected, and the related factors of rotavirus infection were analyzed by univariate statistical analysis. Further multivariate regression analysis was performed to analyze the risk factors for infection. Results 51 cases of rotavirus were detected in 200 children with acute diarrhea, the detection rate of rotavirus was 25.5%, and the detection rate of rotavirus was significantly higher in children of different months of age (P0.05), and the detection rate of rotavirus was higher in children aged 6 to 12 months. The detection rate of rotavirus infection in different seasons was statistically significant (P0.05). The detection rate of rotavirus infection in autumn and winter was 39.5% and 46.3%, respectively, and the positive rate of rotavirus infection in children with rotavirus infection was higher than that in different traits. The difference was statistically significant (P0.05), in which the positive rate was the highest in children with Egg & vegetable soup like diarrhea (47.9%), and the expression level of IL-2mIL-6 TNFINF- 偽 in serum of children with rotavirus infection was significantly higher than that of non-infected children. All the differences were statistically significant (P0.05). The results of univariate analysis showed that breast feeding, children's picky feeding, hand hygiene, hospital stay for 15 days, invasive examination, Continuous use of antimicrobial agents for 1 week and enteral microecological preparations were associated with rotavirus infection in children (P0.05). The results of multielement regression analysis of non-conditional logistic showed that breast milk was used for 15 days and antibiotics were continuously used for 1 week. The use of intestinal microecological agents is an independent risk factor for rotavirus infection. Conclusion the detection rate of rotavirus in feces of children with acute diarrhea is high. The detection rate of rotavirus is the highest in autumn and winter, the highest in the autumn and winter seasons, and the highest in breast-feeding. Hospital stay for 15 days, continuous use of antibiotics for 1 week and the use of intestinal microecological agents were closely related to rotavirus infection.
【作者單位】： 煙臺市煙臺山醫(yī)院兒科;煙臺市煙臺山醫(yī)院檢驗科;
【分類號】：R725.1

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