幼年特發(fā)性關(guān)節(jié)炎患兒生長狀態(tài)及骨密度檢測
發(fā)布時間：2018-07-26 12:32
【摘要】：目的：了解JIA患兒生長發(fā)育及骨密度現(xiàn)狀。 方法：選擇2011.7-2012.2期間重慶醫(yī)科大學(xué)附屬兒童醫(yī)院風(fēng)濕免疫科門診及住院的JIA患兒50名作為研究組，其中女26例，男24例，年齡范圍3-17歲，平均年齡9.97±3.98歲。人體測量包括患兒身高、體重，同時計(jì)算身高和體重的Z值。矮小和低體重均定義為Z值-2。青春期性發(fā)育評估參照Tanner分期，記錄每個青春期女性患兒的初潮年齡。同時由定量超聲骨密度儀測量骨密度。檢測C反應(yīng)蛋白（CRP）、紅細(xì)胞沉降率（ESR）�；純旱挠盟幥闆r通過詢問以及查看既往病例記錄獲得。同時設(shè)立年齡和性別與研究組相似的健康對照組兒童50名。 結(jié)果：50例JIA患兒中身材矮小17例（34%），低體重4例（8%）。JIA組身高的Z值比對照組顯著降低（P0.0001）；JIA組體重Z值亦明顯低于對照組（P0.01）；激素組JIA患兒的身高Z值低于非激素組（P0.05）；JIA活動組患兒身高Z值低于非活動組（P0.01）；身高Z值與病程呈負(fù)相關(guān)（r：-0.28；P0.05），與ESR也呈負(fù)相關(guān)（r：-0.48；P0.0001）；身高Z值與起病年齡、疾病分型之間未發(fā)現(xiàn)統(tǒng)計(jì)學(xué)差異。JIA組青春期女性患兒的初潮平均年齡與對照組之間亦未發(fā)現(xiàn)統(tǒng)計(jì)學(xué)差異。JIA組骨密度Z值與對照組相比有降低（p0.05）；JIA活動組患兒骨密度Z值低于非活動組（P0.001）；JIA患兒骨密度的Z值與病程呈負(fù)相關(guān)（r：-0.4；P0.01），，與ESR呈負(fù)相關(guān)(r:-4.9:P0.0001)。JIA患兒的骨密度Z值與起病年齡、疾病分型、以及是否應(yīng)用激素之間未發(fā)現(xiàn)統(tǒng)計(jì)學(xué)差異。 結(jié)論：JIA患兒普遍存在生長障礙和輕度的骨密度減低。JIA患兒應(yīng)該定期檢測骨密度，以助于早期發(fā)現(xiàn)骨質(zhì)疏松。糖皮質(zhì)激素對JIA患兒生長有抑制作用，合理應(yīng)用激素對JIA的生長發(fā)育意義深遠(yuǎn)。早期診斷和控制疾病的活動對防止JIA患兒發(fā)生骨質(zhì)疏松和生長遲滯非常重要。
[Abstract]:Objective: to investigate the status of growth and bone mineral density in children with JIA. Methods: a total of 50 children with JIA from the Department of Rheumatology and Immunology, affiliated Children's Hospital of Chongqing Medical University, were selected as the study group from January to February 2012.There were 26 females and 24 males, aged 3-17 years, with an average age of 9.97 鹵3.98 years. Anthropometric measurements included height and weight, and Z values of height and weight were calculated. Both short and low body weight are defined as Z-2. According to the Tanner stage, the puberty sexual development assessment recorded the menarche age of each adolescent female child. Bone mineral density (BMD) was measured by quantitative ultrasound absorptiometry. Detection of erythrocyte sedimentation rate of C-reactive protein (CRP), (ESR). The medication was obtained by questioning and reviewing past cases. At the same time, 50 healthy children with similar age and sex were enrolled in the study group. Results among 50 cases of JIA, 17 cases (34%) were short, 4 cases (8%) were low weight, Z value of JIA group was significantly lower than that of control group (P0.0001), Z value of JIA group was lower than that of control group (P0.01), Z value of JIA group was lower than that of non-hormone group (P0.05). The Z value of height in JIA active group was lower than that in inactive group (P0.01), the Z value of height was negatively correlated with the course of disease (r: -0.28 P 0.05), and negatively correlated with ESR (r: -0.48 P 0.0001), and the height Z value was associated with onset age. The mean age of menarche in JIA group was not significantly different from that in control group. The Z value of bone mineral density in JIA group was lower than that in control group (p0.05). The Z value of BMD in the active group of JIA was lower than that in the inactive group (P0.001). The Z value of BMD was negatively correlated with the course of disease (r: -0.4 P 0.01), and negatively correlated with the ESR (r:-4.9:P0.0001). The Z value of BMD was correlated with the onset age and the type of disease. No statistical difference was found between the use of hormones and whether or not they were used. Conclusion growth disorder and slight decrease of bone mineral density are common in children with JIA. Bone mineral density should be measured regularly in order to help early detection of osteoporosis. Glucocorticoids can inhibit the growth of children with JIA. The rational use of glucocorticoids has a profound effect on the growth and development of JIA. Early diagnosis and control of disease activities are important to prevent osteoporosis and growth retardation in children with JIA.
【學(xué)位授予單位】：重慶醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2012
【分類號】：R725.9
本文編號：2146026
[Abstract]:Objective: to investigate the status of growth and bone mineral density in children with JIA. Methods: a total of 50 children with JIA from the Department of Rheumatology and Immunology, affiliated Children's Hospital of Chongqing Medical University, were selected as the study group from January to February 2012.There were 26 females and 24 males, aged 3-17 years, with an average age of 9.97 鹵3.98 years. Anthropometric measurements included height and weight, and Z values of height and weight were calculated. Both short and low body weight are defined as Z-2. According to the Tanner stage, the puberty sexual development assessment recorded the menarche age of each adolescent female child. Bone mineral density (BMD) was measured by quantitative ultrasound absorptiometry. Detection of erythrocyte sedimentation rate of C-reactive protein (CRP), (ESR). The medication was obtained by questioning and reviewing past cases. At the same time, 50 healthy children with similar age and sex were enrolled in the study group. Results among 50 cases of JIA, 17 cases (34%) were short, 4 cases (8%) were low weight, Z value of JIA group was significantly lower than that of control group (P0.0001), Z value of JIA group was lower than that of control group (P0.01), Z value of JIA group was lower than that of non-hormone group (P0.05). The Z value of height in JIA active group was lower than that in inactive group (P0.01), the Z value of height was negatively correlated with the course of disease (r: -0.28 P 0.05), and negatively correlated with ESR (r: -0.48 P 0.0001), and the height Z value was associated with onset age. The mean age of menarche in JIA group was not significantly different from that in control group. The Z value of bone mineral density in JIA group was lower than that in control group (p0.05). The Z value of BMD in the active group of JIA was lower than that in the inactive group (P0.001). The Z value of BMD was negatively correlated with the course of disease (r: -0.4 P 0.01), and negatively correlated with the ESR (r:-4.9:P0.0001). The Z value of BMD was correlated with the onset age and the type of disease. No statistical difference was found between the use of hormones and whether or not they were used. Conclusion growth disorder and slight decrease of bone mineral density are common in children with JIA. Bone mineral density should be measured regularly in order to help early detection of osteoporosis. Glucocorticoids can inhibit the growth of children with JIA. The rational use of glucocorticoids has a profound effect on the growth and development of JIA. Early diagnosis and control of disease activities are important to prevent osteoporosis and growth retardation in children with JIA.
【學(xué)位授予單位】：重慶醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2012
【分類號】：R725.9
【參考文獻(xiàn)】
相關(guān)期刊論文 前2條
1 張倩,馬冠生;體力活動對骨量的影響[J];國外醫(yī)學(xué).衛(wèi)生學(xué)分冊;2005年04期
2 周毅;梁志昂;林慶衍;孫楠;;短期小劑量激素治療中老年類風(fēng)濕性關(guān)節(jié)炎對患者骨密度的影響[J];廣東醫(yī)學(xué);2006年06期
本文編號：2146026
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