【摘要】：目的探討茵梔黃口服液聯(lián)合清蛋白治療新生兒病理性黃疸療效、安全性及可能機(jī)制。方法收集150例新生兒病理性黃疸患兒,分為對照組75例和觀察組75例。常規(guī)治療基礎(chǔ)上,對照組給予清蛋白,而觀察組則聯(lián)合給予茵梔黃口服液治療。比較對照組和觀察組患兒臨床療效、血清膽紅素水平、膽紅素下降速度、血清超敏C反應(yīng)蛋白(hs-CRP)、甲胎蛋白(AFP)、轉(zhuǎn)鐵蛋白(TRF)水平及不良反應(yīng)發(fā)生情況。結(jié)果療效評價顯示,觀察組患兒治療總有效率明顯高于對照組(96.0%vs.86.7%,P0.05)。治療后,與對照組相比,觀察組患兒血清膽紅素水平顯著降低(110.2±17.1)μmol/L vs.(148.8±19.1)μmol/L,膽紅素日均下降程度更明顯[(45.1±4.5)μmol·L-1·d-1 vs.(28.3±5.2)μmol·L-1·d-1],退黃時間明顯縮短[(5.1±1.8)d vs.(7.6±1.6)d],血清hs-CRP、AFP水平明顯降低[(7.3±1.6)mg/L vs.(13.7±2.2)mg/L,(13.2±2.1)mg/L vs.(18.1±2.5)mg/L],TRF水平明顯升高(1.97±0.28)g/L vs.(1.64±0.24)g/L,組間比較差異均有統(tǒng)計(jì)學(xué)意義(均P0.05)。治療期間,兩組患兒均未出現(xiàn)嚴(yán)重不良反應(yīng)病例,觀察組不良反應(yīng)發(fā)生率明顯低于對照組(8.0%vs.20.0%,P0.05)。結(jié)論茵梔黃口服液聯(lián)合清蛋白治療新生兒病理性黃疸療效可靠,能夠顯著提高臨床療效,臨床上值得進(jìn)一步研究。
[Abstract]:Objective to investigate the efficacy, safety and possible mechanism of Yinzhihuang oral liquid combined with albumin in the treatment of neonatal pathological jaundice. Methods 150 neonates with pathological jaundice were divided into control group (75 cases) and observation group (75 cases). On the basis of routine treatment, the control group was given albumin, while the observation group was treated with Yinzhihuang oral liquid. The clinical efficacy, serum bilirubin level, decreasing rate of bilirubin, serum hypersensitive C-reactive protein (hs-CRP), alpha-fetoprotein (AFP), transferrin (TRF) and adverse reactions were compared between the control group and the observation group. Results the total effective rate of the observation group was significantly higher than that of the control group (96.0vs.86.7p0.05). After treatment, compared with the control group, 瑙傚療緇勬?zhèn)ｅ効琛�娓呰儐綰㈢礌姘村鉤鏄捐憲闄嶄綆(110.2鹵17.1)渭mol/L vs.(148.8鹵19.1)渭mol/L,鑳嗙孩绱犳棩鍧囦笅闄嶇▼搴︽洿鏄庢樉[(45.1鹵4.5)渭mol路L-1路d-1 vs.(28.3鹵5.2)渭mol路L-1路d-1],閫，

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