【摘要】：目的探討紅霉素序貫療法對支原體肺炎患兒免疫球蛋白、細胞因子變化以及對患兒預后的影響。方法選擇2014年2—9月就診于本院兒科的支原體肺炎患兒118例,采用隨機數(shù)字表法將患兒分為觀察組與對照組各59例。觀察組采用紅霉素序貫療法,對照組采用常規(guī)紅霉素單純靜脈滴注療法,比較兩組患兒的免疫球蛋白、細胞因子水平及患兒預后(有效率及不良反應發(fā)生率)。結果治療前,兩組IgA、IgM、IgG水平比較,差異無統(tǒng)計學意義(P0.05);治療后,觀察組的IgA、IgM、IgG水平均較對照組升高,差異有統(tǒng)計學意義(P0.05)。治療前,兩組IL-6、IL-8比較,差異均無統(tǒng)計學意義(P0.05);治療后,觀察組的IL-6、IL-8水平低于對照組,差異有統(tǒng)計學意義(P0.05)。觀察組患兒的有效率高于對照組,差異有統(tǒng)計學意義(P0.05)。觀察組僅1例發(fā)生皮疹,對照組發(fā)生胃腸道反應2例、皮疹3例、藥物熱2例,觀察組不良反應發(fā)生率低于對照組,差異有統(tǒng)計學意義(P0.05)。結論采用紅霉素序貫療法有助于提高支原體肺炎患兒的免疫球蛋白水平、改善細胞因子水平,在提高患兒治療有效率的同時,不良反應發(fā)生率低,安全性高,值得臨床推廣。
[Abstract]:Objective to investigate the effect of erythromycin sequential therapy on immunoglobulin, cytokines and prognosis in children with mycoplasma pneumonia. Methods 118 children with mycoplasma pneumonia from February to September 2014 were randomly divided into two groups: observation group (n = 59) and control group (n = 59). The observation group was treated with erythromycin sequential therapy, and the control group was treated with routine erythromycin intravenous drip. The immunoglobulin, cytokine level and prognosis (effective rate and adverse reaction rate) were compared between the two groups. Results before treatment, there was no significant difference between the two groups (P0.05), but after the treatment, the IgG level of the observation group was higher than that of the control group, the difference was statistically significant (P0.05). Before treatment, the two groups of IL-6 IL-8 comparison, there was no statistical significance (P0.05); after treatment, the level of IL-6 IL-8 in the observation group was lower than that in the control group, the difference was statistically significant (P0.05). The effective rate of the observation group was higher than that of the control group, the difference was statistically significant (P0.05). In the observation group, there were only 1 case of rash, 2 cases of gastrointestinal reaction, 3 cases of rash and 2 cases of drug fever in the control group. The incidence of adverse reactions in the observation group was lower than that in the control group (P0.05). Conclusion Erythromycin sequential therapy can improve the level of immunoglobulin and cytokines in children with mycoplasma pneumonia.
【作者單位】： 浙江省瑞安市人民醫(yī)院;
【分類號】：R725.6

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