腎移植患兒術(shù)后應(yīng)用糖皮質(zhì)激素治療研究現(xiàn)狀
發(fā)布時間:2018-07-21 18:23
【摘要】:正糖皮質(zhì)激素是腎移植患兒術(shù)后傳統(tǒng)免疫抑制方案的核心藥物。但是,長期應(yīng)用糖皮質(zhì)激素會導致諸多不良反應(yīng),包括庫欣面容、高血壓、高脂血癥、類固醇糖尿病、感染、生長發(fā)育障礙、骨質(zhì)疏松和移植后淋巴細胞增殖性疾病等~[1]。其中,生長發(fā)育遲緩和身材矮小尤其值得關(guān)注。此外,高血壓、高脂血癥和類固醇糖尿病等均可增加心血管疾病風險,甚至導致移植失敗~[2]。因此,眾多研究者開始致力于改進腎移植術(shù)后免疫抑制方案,探討術(shù)后減少甚至無
[Abstract]:Glucocorticoid is the core drug of traditional immunosuppressive regimen after renal transplantation in children. However, long-term use of glucocorticoids can lead to a number of adverse reactions, including Cushing's face, hypertension, hyperlipidemia, steroid diabetes, infection, dysplasia of growth, osteoporosis and post-transplant lymphoproliferative diseases. Among them, growth retardation and short stature are of particular concern. In addition, hypertension, hyperlipidemia and steroid diabetes can increase the risk of cardiovascular disease and even lead to transplant failure. Therefore, many researchers began to work on improving immunosuppressive protocols after renal transplantation, and to explore the reduction or absence of post-operative immunosuppression.
【作者單位】: 北京大學第一醫(yī)院;
【分類號】:R726.9
本文編號:2136389
[Abstract]:Glucocorticoid is the core drug of traditional immunosuppressive regimen after renal transplantation in children. However, long-term use of glucocorticoids can lead to a number of adverse reactions, including Cushing's face, hypertension, hyperlipidemia, steroid diabetes, infection, dysplasia of growth, osteoporosis and post-transplant lymphoproliferative diseases. Among them, growth retardation and short stature are of particular concern. In addition, hypertension, hyperlipidemia and steroid diabetes can increase the risk of cardiovascular disease and even lead to transplant failure. Therefore, many researchers began to work on improving immunosuppressive protocols after renal transplantation, and to explore the reduction or absence of post-operative immunosuppression.
【作者單位】: 北京大學第一醫(yī)院;
【分類號】:R726.9
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