本文選題：質(zhì)子泵抑制劑 + 嬰兒��； 參考：《中國(guó)醫(yī)院藥學(xué)雜志》2017年10期

【摘要】：目的:探討質(zhì)子泵抑制劑(PPIs)在治療嬰兒胃食管反流性疾病(GERD)中的安全性。方法:收集已發(fā)表的有關(guān)使用PPIs治療嬰兒GERD發(fā)生藥物不良反應(yīng)(ADR)的研究,對(duì)檢索到的原始資料進(jìn)行質(zhì)量評(píng)估,對(duì)總ADR以及單個(gè)ADR進(jìn)行分析。結(jié)果:共納入4篇文獻(xiàn),總樣本量為617例,其中PPIs組352例,安慰劑組265例�？侫DR的RR值為1.27,可信區(qū)間為(1.06,1.51),P=0.008,單個(gè)ADR中除發(fā)熱外,其余PPIs組與安慰劑組無(wú)顯著性差異。結(jié)論:質(zhì)子泵抑制劑在治療嬰兒GERD過(guò)程中總ADR發(fā)生概率高于安慰劑組,但因納入研究較少、質(zhì)量尚缺乏、樣本含量小,需要更多高質(zhì)量的隨機(jī)對(duì)照試驗(yàn)以及觀察性研究去進(jìn)一步論證。
[Abstract]:Objective: to investigate the safety of proton pump inhibitor (PPIs) in the treatment of gastroesophageal reflux disease (GERD) in infants. Methods: the published studies on the use of PPIs in the treatment of adverse drug reactions (ADR) in infants with GERD were collected, the quality of the retrieved data was evaluated, and the total ADR and single ADR were analyzed. Results: a total of 617 cases were included in 4 articles, of which 352 cases were PPIs group and 265 cases were placebo group. The RR value of total ADR was 1.27 and the confidence interval was (1.06 鹵1.51). There was no significant difference between PPIs group and placebo group except fever. Conclusion: the probability of total ADR in the treatment of GERD in infants with proton pump inhibitors is higher than that in the placebo group. More high-quality randomized controlled trials and observational studies are needed for further demonstration.
【作者單位】： 懷化市第一人民醫(yī)院臨床藥學(xué)研究室;懷化市循證醫(yī)學(xué)與臨床研究中心;中南大學(xué)藥學(xué)院;中南大學(xué)臨床藥理研究所;
【基金】：湖南省醫(yī)藥衛(wèi)生科研項(xiàng)目計(jì)劃(編號(hào):B2015-181) 2015年懷化市科技局項(xiàng)目計(jì)劃(編號(hào):2015F3104)
【分類號(hào)】：R725.7

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