發(fā)布時間：2018-06-23 21:21

  本文選題：大氣污染 + 先天性心臟病�。� 參考：《中國公共衛(wèi)生》2017年08期

【摘要】：目的探討大氣污染與出生缺陷即先天性心臟病(以下簡稱先心病)之間是否具有相關(guān)性。方法以妊娠期間居住于沈陽市、末次月經(jīng)位于2006年1月1日—2010年12月31日且分娩先心病缺陷患兒的孕產(chǎn)婦共計842例為研究對象,利用病例對照研究分析妊娠婦女在妊娠前后暴露于大氣污染物中與分娩先心病患兒之間的關(guān)系。結(jié)果沈陽市屬中國大氣污染較為嚴重的地區(qū),每年的1—3月、11、12月是各污染物濃度均較高的時期,其中SO_2濃度最高時達到145.9μg/m~3,NO_2為541.4μg/m~3,PM10為163.6μg/m~3,每年的7月是SO_2、NO_2濃度較低的時期,SO_2為22μg/m~3,NO_2為27.2μg/m~3,PM10濃度最低月份在8月,為90.6μg/m~3,每月間污染物濃度差異有統(tǒng)計學意義。分娩先心病患兒孕婦在妊娠前2、3個月的SO_2暴露均值高于對照組,在妊娠第2、3個月的NO_2暴露均值高于對照組,妊娠前1、2、3個月、妊娠第1、2、3個月的所在地區(qū)PM10平均暴露濃度均高于對照組,且差異有統(tǒng)計學意義。結(jié)論妊娠婦女孕前3個月及妊娠早期應避免暴露于大氣污染物濃度較高的地區(qū),因其可能會誘發(fā)胎兒先心病的發(fā)生。
[Abstract]:Objective to investigate the relationship between air pollution and congenital heart disease (CHD). Methods A total of 842 pregnant women who lived in Shenyang during pregnancy and whose last menstruation was from January 1, 2006 to December 31, 2010, and who had congenital heart disease defects, were studied. Case-control study was used to analyze the relationship between exposure to air pollutants before and after pregnancy and children with congenital heart disease. Results Shenyang is a serious area of air pollution in China. The concentration of each pollutant is higher in December than in January to January each year. Among them, the highest concentration of SO2 is 145.9 渭 g / m ~ (3) no _ 2 = 541.4 渭 g / m ~ (-1) PM10 = 163.6 渭 g / m ~ (-1), and every year July is a period when so _ 2s _ (No2) is 22 渭 g 路m ~ (3) / min ~ (-1). The lowest month of the concentration of PM10 is 27.2 渭 g / m ~ (3) / min ~ (-1), which is 90.6 渭 g / m ~ (-3) in August, and there is a statistically significant difference in the concentration of pollutants between months. The mean value of SO2 exposure in pregnant women with congenital heart disease was higher than that in the control group at 2 and 3 months before pregnancy, and the mean value of No2 exposure in the 2nd and 3rd month of pregnancy was higher than that in the control group. The mean exposure concentration of PM10 in the first and third month of pregnancy was higher than that in the control group, and the difference was statistically significant. Conclusion three months before pregnancy and early pregnancy, women should avoid exposure to high concentration of atmospheric pollutants, which may induce fetal congenital heart disease.
【作者單位】： 沈陽市婦幼保健院科教科;沈陽理工大學環(huán)境與化學工程學院;遼寧省環(huán)境監(jiān)測實驗中心;
【基金】：遼寧省科學技術(shù)計劃項目(2015225025) 遼寧省科學事業(yè)公益研究基金項目(201500100) 沈陽市科學技術(shù)計劃項目(F15-139-9-09) 遼寧省沈陽市衛(wèi)計委青年科研項目(沈衛(wèi)辦[2015]479號)
【分類號】：R12;R725.4

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