發(fā)布時間：2018-06-19 13:16

  本文選題：嗜酸性肉芽腫 + 單發(fā)��； 參考：《中山大學(xué)學(xué)報(醫(yī)學(xué)科學(xué)版)》2017年05期

【摘要】：【目的】探討小劑量化療、手術(shù)及手術(shù)加術(shù)后輔助小劑量化療這三種不同的方法在兒童孤立性骨嗜酸性肉芽腫(SBL-EG)治療上的有效性及可行性�！痉椒ā炕仡櫺苑治隽�149例SBL-EG的兒童患者,其中86例接受小劑量化療,33例行手術(shù)治療,30例接受手術(shù)及術(shù)后輔助小劑量化療。比較三組患者的住院時間、癥狀緩解時間、恢復(fù)時間、治療費用、并發(fā)癥及無復(fù)發(fā)生存時間(RFS)�！窘Y(jié)果】小劑量化療組的住院時間、癥狀緩解時間、恢復(fù)時間及治療費用均低于手術(shù)或手術(shù)加化療組(P0.05),而手術(shù)組與手術(shù)加化療組在上述4個方面的對比均無明顯統(tǒng)計學(xué)差異(P0.05)。小劑量化療組及手術(shù)加化療組中化療藥物相關(guān)的副作用包括惡心(8.62%),轉(zhuǎn)氨酶升高(7.76%),輕度脫發(fā)(4.31%),抵抗力下降(21.55%),生長發(fā)育遲滯(10.34%)及滿月臉(7.76%)。小劑量化療組及手術(shù)加化療組的RFS(147月及126月)明顯長于手術(shù)組(114月)(P=0.005及0.019)。然而,小劑量化療組及手術(shù)加化療組的RFS差異無統(tǒng)計學(xué)意義(P=0.732)�！窘Y(jié)論】在SBL-EG的兒童患者治療上,相對于手術(shù)或手術(shù)加化療而言,小劑量化療是一種創(chuàng)傷小、恢復(fù)快、經(jīng)濟、安全有效的方法。
[Abstract]:[objective] to study the low dose chemotherapy, The efficacy and feasibility of three different methods of adjuvant small dose chemotherapy in children with isolated bone eosinophilic granulomatosis (SBL-EGG) were studied. [methods] 149 cases of children with SBL-EG were retrospectively analyzed. Among them, 86 cases received small dose chemotherapy and 33 cases received surgical treatment and 30 cases received surgery and postoperative adjuvant small dose chemotherapy. The hospitalization time, symptom remission time, recovery time, treatment cost, complication and survival time without recurrence were compared among the three groups. [results] the hospitalization time, symptom remission time of the small dose chemotherapy group were compared. The recovery time and the cost of treatment were lower than those of the operation or operation plus chemotherapy group (P 0.05), but there was no significant difference between the operation group and the operation plus chemotherapy group in the above four aspects. The side effects of chemotherapy-related drugs in the low dose chemotherapy group and the operation plus chemotherapy group included nausea 8.62am, aminotransferase increased 7.76g, mild alopecia 4.31%, resistance decreased 21.55%, growth retardation 10.34%) and full moon 7.76g. RFSs in the small dose chemotherapy group and the operation plus chemotherapy group were significantly longer than those in the operation group (14.7 months and 12.6 months). However, there was no significant difference in RFS between the small dose chemotherapy group and the operation plus chemotherapy group. [conclusion] in the treatment of children with SBL-EG, compared with surgery or surgery plus chemotherapy, small dose chemotherapy is a kind of small trauma, quick recovery and economic. A safe and effective method.
【作者單位】： 中山大學(xué)附屬第一醫(yī)院骨腫瘤科;華南腫瘤學(xué)國家重點實驗室//中山大學(xué)腫瘤防治中心;
【基金】：國家自然科學(xué)基金面上項目(81572638) 廣東省自然科學(xué)基金(S2013010015384,2014A030313219)
【分類號】：R726.8
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本文編號：2040013