本文選題：過敏性紫癜 + 治療��； 參考：《吉林大學(xué)》2012年碩士論文

【摘要】：目的：探討抗幽門螺桿菌（Helicobacter pylori，HP）治療腹型過敏性紫癜（Henoch-Sch nlein purpura,HSP）的臨床療效。 資料與方法：選擇2009年10月至2012年1月吉林大學(xué)中日聯(lián)誼醫(yī)院兒科住院及門診128例已確診為過敏性紫癜且均不同程度伴有惡心、嘔吐、腹痛、腹瀉及便血等胃腸道癥狀的患兒，采用血幽門螺旋桿菌檢測及胃鏡取活檢組織檢測HP法進(jìn)行HP檢測，兩項(xiàng)檢測結(jié)果均呈陽性者為HP感染陽性，結(jié)果HP感染陽性者88例。將88例HP陽性的過敏性紫癜患兒完全隨機(jī)分為兩組，治療組與對照組各44例。對照組患兒給予HSP常規(guī)方案治療，即：抗過敏、激素治療，若有感染患兒適當(dāng)給予抗生素治療。治療組患兒除常規(guī)方案治療外，加用抗HP三聯(lián)療法：奧美拉唑0.8mg/kg d，2次/d，阿莫西林50mg/kg d，3次/d，克拉霉素15mg/kg d，2次/d，療程2周。2周后根據(jù)HSP療效判斷標(biāo)準(zhǔn)分別計算兩組患兒治療有效率，并對其進(jìn)行隨訪分別記錄兩組患兒復(fù)發(fā)率。最后采用SPSS17.0軟件進(jìn)行對兩組數(shù)據(jù)進(jìn)行χ2檢驗(yàn)，分析比較是否存在統(tǒng)計學(xué)差異。 結(jié)果：全部128例患兒應(yīng)用血幽門螺旋桿菌檢測及胃鏡取活檢組織檢測HP法進(jìn)行HP檢測，兩項(xiàng)檢測結(jié)果均呈陽性者為HP感染陽性，結(jié)果HP感染陽性者88例，HP陽性檢出率為68.75%；治療組加入抗HP治療后有效率為95.5%，對照組有效率為72.2%，兩組數(shù)據(jù)差異具有統(tǒng)計學(xué)意義（P0.05）；治療組抗HP治療后，胃腸道癥狀緩解迅速，復(fù)發(fā)率為9.5%，而對照組為18.9%，兩組數(shù)據(jù)差異具有統(tǒng)計學(xué)意義（P0.05）。 結(jié)論：HP感染與腹型過敏性紫癜相關(guān)密切，對于過敏性紫癜患兒，，尤其是合并有胃腸道癥狀的患兒，應(yīng)盡早做HP常規(guī)檢測，對于HP檢測陽性者在常規(guī)治療的基礎(chǔ)上加入抗HP治療，可有效提高治療療效，盡早控制癥狀，縮短病程，降低復(fù)發(fā)率，對改善過敏性紫癜的預(yù)后意義重大，應(yīng)引起臨床的高度重視。
[Abstract]:Objective: to investigate the clinical efficacy of Helicobacter pylori (Helicobacter pylori) in the treatment of Henoch-Sch nlein purpura (HSP). Materials and methods: from October 2009 to January 2012, 128 children with gastrointestinal symptoms, including nausea, vomiting, abdominal pain, diarrhoea and hematochezia, were diagnosed as allergic purpura in pediatric and outpatient department of Sino-Japanese Friendship Hospital of Jilin University. HP was detected by blood Helicobacter pylori test and biopsy by gastroscope. The HP infection was positive in both cases and 88 cases were HP positive. 88 cases of HP positive Henoch-Schonlein purpura were randomly divided into two groups, 44 cases in the treatment group and 44 cases in the control group. In the control group, the patients were treated with the routine regimen of HSP, that is, antiallergic, hormone therapy, and antibiotic therapy if there was infection. In the treatment group, in addition to routine treatment, the treatment group was treated with anti-HP triple therapy: omeprazole 0.8mg/kg dan2 / d, amoxicillin 50mg/kg dan3 / d, clarithromycin 15mg/kg dan2 / d. After 2 weeks of treatment, the effective rates of the two groups were calculated according to the criteria for judging the curative effect of HSP2. The recurrence rates of the two groups were recorded by follow-up. Finally, SPSS 17.0 software was used to carry on 蠂 2 test to the two groups of data, and the statistical difference was analyzed and compared. Results: all 128 children were tested for HP by blood helicobacter pylori test and biopsy under gastroscopy. The HP positive rate was found in 88 patients with HP infection, and the HP positive rate was 68.75 in 88 patients with HP infection. The effective rate of anti-HP treatment was 95.5g in the treatment group and 72.2in the control group, and the difference between the two groups was statistically significant (P 0.05). The recurrence rate was 9.5%, while that in the control group was 18.9%. The difference between the two groups was statistically significant (P 0.05). Conclusion the infection of HP is closely related to the abdominal anaphylactoid purpura. Routine detection of HP should be done as soon as possible in children with Henoch-Schonlein purpura, especially in children with gastrointestinal symptoms. For HP positive patients, adding anti-HP therapy on the basis of routine treatment can effectively improve the therapeutic effect, control symptoms as soon as possible, shorten the course of disease and reduce the recurrence rate. It is of great significance to improve the prognosis of Henoch-Schonlein purpura. Clinical attention should be paid to it.
【學(xué)位授予單位】：吉林大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2012
【分類號】：R725.5

【參考文獻(xiàn)】

相關(guān)期刊論文 前4條

1 史學(xué),李歆;過敏性紫癜與幽門螺桿菌感染關(guān)系的探討[J];北京醫(yī)學(xué);2002年02期

2 盧立肖,胡偉國;過敏性紫癜的胃腸道表現(xiàn)及其與幽門螺桿菌的關(guān)系[J];中國當(dāng)代兒科雜志;2001年01期

3 趙桂杰,周建芹;腹型過敏性紫癜的臨床特點(diǎn)分析[J];中國當(dāng)代兒科雜志;2001年03期

4 王秉慧;周麗群;左亞華;;兒童腹型過敏性紫癜與幽門螺桿菌感染的關(guān)系探討[J];中國當(dāng)代兒科雜志;2007年04期

本文編號：2018207