本文選題：雙環(huán)醇 + 更昔洛韋��； 參考：《中國藥房》2017年23期

【摘要】：目的:探究雙環(huán)醇聯(lián)合更昔洛韋治療嬰兒巨細(xì)胞病毒性肝炎的臨床療效及安全性。方法:選取2012年5月-2015年8月我院兒科收治的巨細(xì)胞病毒性肝炎患兒120例,按隨機(jī)數(shù)字表法分為觀察組和對(duì)照組,各60例。兩組患兒均給予常規(guī)治療,包括保肝、補(bǔ)充維生素C和維生素K等,并給予復(fù)方甘草酸苷注射液20 m L,ivgtt,qd。對(duì)照組患兒在上述治療的基礎(chǔ)上給予更昔洛韋葡萄糖注射液(誘導(dǎo)期5 mg/kg,q12 h,每次滴注時(shí)間1 h,持續(xù)7 d;維持期5 mg/kg,q24 h,持續(xù)7 d);觀察組患兒在對(duì)照組的基礎(chǔ)上口服雙環(huán)醇片0.5 mg/kg,bid。觀察兩組患兒臨床療效及治療前后肝酶、黃疸水平,并比較CMV轉(zhuǎn)陰率及不良反應(yīng)發(fā)生情況。結(jié)果:觀察組患兒臨床總有效率為93.3%,顯著高于對(duì)照組的80.0%,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。治療前,兩組患兒肝酶和黃疸水平比較,差異均無統(tǒng)計(jì)學(xué)意義(P0.05);治療后,兩組患兒肝酶和黃疸水平均顯著降低,且觀察組水平顯著低于對(duì)照組,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。觀察組患兒CMV總轉(zhuǎn)陰率為85.0%,顯著高于對(duì)照組的73.3%,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。兩組患兒不良反應(yīng)發(fā)生率比較,差異無統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:雙環(huán)醇聯(lián)合更昔洛韋治療嬰兒巨細(xì)胞病毒性肝炎療效顯著,能有效降低患兒血清肝酶水平、消除黃疸、保護(hù)肝功能、促進(jìn)病毒轉(zhuǎn)陰,且安全性較高。
[Abstract]:Objective: to investigate the efficacy and safety of bicyclol combined with ganciclovir in the treatment of infantile cytomegalovirus hepatitis. Methods: 120 children with cytomegalovirus hepatitis from May 2012 to August 2015 were randomly divided into observation group (n = 60) and control group (n = 60). Both groups were given routine treatment, including liver protection, supplementation of vitamin C and vitamin K, and 20 mL of compound glycyrrhizin injection iv GTT QD. The control group was given ganciclovir glucose injection (5 mg 路kg ~ (-1) 路kg ~ (-1) for 12 h, each time for 7 days, while the maintenance period was 5 mg / kg ~ (-1) Q for 24 h for 7 days, and the observation group was given dicyclol tablet 0.5 mg 路kg ~ (-1) bid on the basis of the control group, and the control group was treated with ganciclovir glucose injection (5 mg 路kg ~ (-1) 路kg ~ (-1) for 12 h. The clinical curative effect, liver enzyme and jaundice were observed before and after treatment, and the negative rate of CMV and the incidence of adverse reactions were compared between the two groups. Results: the total clinical effective rate of the observation group was 93.3, which was significantly higher than that of the control group (80.05%), and the difference was statistically significant (P 0.05). Before treatment, the levels of liver enzyme and jaundice were not significantly different between the two groups, but the levels of liver enzyme and jaundice in the two groups were significantly lower than those in the control group (P 0.05). The total negative rate of CMV in the observation group was 85.0, which was significantly higher than that in the control group (73.3%), and the difference was statistically significant (P 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P 0.05). Conclusion: bicyclol combined with ganciclovir is effective in the treatment of infantile cytomegalovirus hepatitis. It can effectively reduce serum hepatic enzyme level, eliminate jaundice, protect liver function and promote virus negative conversion.
【作者單位】： 南陽醫(yī)學(xué)高等�？茖W(xué)校第一附屬醫(yī)院兒科;南陽醫(yī)學(xué)高等�？茖W(xué)校第二附屬醫(yī)院內(nèi)科;
【分類號(hào)】：R725.1

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本文編號(hào)：2010423