本文選題：神經(jīng)保護因子 + 巨細胞病毒感染　； 參考：《廣東醫(yī)學》2017年08期

【摘要】：目的探討神經(jīng)保護因子早期干預對先天性巨細胞病毒感染新生兒聽力損傷的保護作用。方法48例先天性巨細胞病毒感染新生兒分為兩組,甲組23例用常規(guī)治療(更昔洛韋),乙組25例在常規(guī)治療基礎上增加神經(jīng)保護因子神經(jīng)節(jié)苷酯,分別收集生后3、42 d聽力篩查情況及3個月和6個月腦干聽覺誘發(fā)電位(ABR)檢查結果,分析兩種治療在聽力保護方面的療效。結果乙組患兒在42 d篩查不通過率低于甲組,3個月及6個月ABR檢查V波閾值平均值低于甲組(P0.05)。結論神經(jīng)保護因子對先天性巨細胞病毒感染患兒的聽覺系統(tǒng)有保護作用,可一定程度上降低此類患兒聽力的損傷程度。
[Abstract]:Objective to investigate the protective effect of early intervention of neuroprotective factor on hearing loss in neonates with congenital cytomegalovirus infection. Methods 48 neonates with congenital cytomegalovirus infection were divided into two groups. Group A (23 cases) received routine treatment (ganciclovir), group B (25 cases) increased the neuroprotective factor ganglioside ester on the basis of routine treatment. The results of hearing screening and brainstem auditory evoked potential (ABR) at 3 and 6 months after birth were collected, and the effects of the two treatments on hearing protection were analyzed. Results the screening failure rate of group B was lower than that of group A at 42 days, and the threshold value of V wave in ABR at 3 and 6 months was lower than that in group A (P 0.05). Conclusion Neuroprotective factor has protective effect on hearing system of children with congenital cytomegalovirus infection, and can reduce hearing impairment to some extent in children with congenital cytomegalovirus infection.
【作者單位】： 西安醫(yī)學院第一附屬醫(yī)院兒科;
【分類號】：R722.13
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本文編號：1996647