本文選題：肛門(mén)生殖器距離 + 新生兒��； 參考：《廣州醫(yī)科大學(xué)》2017年碩士論文

【摘要】：背景:肛門(mén)生殖器距離(AGD)是反映人類(lèi)性發(fā)育的重要指標(biāo),目前學(xué)者主要將AGD應(yīng)用于臨床來(lái)衡量雄性化、評(píng)估孕期宮內(nèi)雄激素暴露水平、研究與隱睪及尿道下裂的關(guān)系、評(píng)估成年男性生殖能力等。但是國(guó)內(nèi)對(duì)AGD的研究不多,尚未見(jiàn)單獨(dú)有關(guān)新生兒AGD測(cè)量的報(bào)告。目的:建立足月新生兒AGD的正常參考值,并對(duì)可能影響新生兒AGD的因素進(jìn)行探討,為進(jìn)一步研究AGD與性發(fā)育的關(guān)系提供參考。方法:選取在2017年3月至2017年4月期間出生于廣州醫(yī)科大學(xué)附屬第三醫(yī)院的正常足月新生兒,共205例,其中男性116例,女性89例。所有新生兒均在出生后72h內(nèi)進(jìn)行測(cè)量,測(cè)量工具采取數(shù)顯游標(biāo)卡尺。男性新生兒AGD采用3個(gè)測(cè)量指標(biāo),分別為:肛門(mén)中心至陰囊基底部的距離(ASD);肛門(mén)中心至陰莖基底背側(cè)的距離(AGD1);肛門(mén)中心至陰莖基底腹側(cè)的距離(AGD2)。女性新生兒AGD采用2個(gè)測(cè)量指標(biāo),分別為:肛門(mén)中心至陰唇后聯(lián)合的距離(AFD);肛門(mén)中心至陰蒂的距離(ACD)。每個(gè)指標(biāo)測(cè)量?jī)纱?取平均值,測(cè)量值精確到0.1mm。結(jié)果:1.男性足月新生兒AGD值分別為:ASD:20.6±2.9mm;AGD1:45.7±3.8mm;AGD2:40.0±4.4mm。女性足月新生兒AGD值分別為:AFD:12.5±2.3mm;ACD:35.5±2.1mm。2.不同性別足月新生兒AGD值比較,男性ASD(20.6±2.9mm)大于女性AFD(12.5±2.3mm),男性AGD1(45.7±3.8mm)、AGD2(40.0±4.4mm)均大于女性ACD(35.5±2.1mm),P均0.01,具有顯著統(tǒng)計(jì)學(xué)意義。3.單胎新生兒AGD與雙胎新生兒AGD比較,男性單胎新生兒ASD、AGD1、AGD2均大于雙胎新生兒,分別為20.7±2.9mm VS 18.4±2.0mm、46.0±3.7mm VS 42.4±1.8mm、40.3±4.4mm VS 36.4±2.7mm,P均0.05,差異具有統(tǒng)計(jì)學(xué)意義;女性單胎新生兒AFD、ACD均大于雙胎新生兒,分別為12.6±2.2mm VS 10.7±1.2mm、35.6±2.0mm VS 33.9±1.7mm,P均0.05,差異具有統(tǒng)計(jì)學(xué)意義。4.Pearson相關(guān)分析結(jié)果顯示:胎齡與ASD(r=0.212,P0.050)、AGD1(r=0.276,P0.05)、AGD2(r=0.169,P0.05)、AFD(r=0.270,P0.05)及ACD(r=0.273,P0.05)均呈正相關(guān)。出生體重與ASD(r=0.232,P0.05)、AGD1(r=0.433,P0.05)、AGD2(r=0.320,P0.05)、AFD(r=0.288,P0.05)、ACD(r=0.516,P0.05)均呈正相關(guān)。出生身長(zhǎng)與ASD(r=0.162,P0.05)、AGD1(r=0.324,P0.05)、AGD2(r=0.300,P0.05)、AFD(r=0.246,P0.05)、ACD(r=0.424,P0.05)均呈正相關(guān)。5.不同分娩方式及各種母親因素(包括受孕年齡、孕前體重、產(chǎn)前體重、孕期增重、產(chǎn)婦身高、孕前BMI、孕次、產(chǎn)次)與新生兒AGD均無(wú)相關(guān)性。6.多元逐步回歸分析顯示:出生體重可能是新生兒AGD重要的影響因素(βASD=0.232、βAGD1=0.433、βAGD2=0.320、βAFD=0.288、βACD=0.516;P均0.05)。結(jié)論:本研究共測(cè)量了205例正常足月新生兒,獲得了足月新生兒肛門(mén)生殖器距離的正常參考值。結(jié)果顯示男性新生兒AGD大于女性新生兒AGD,證實(shí)AGD具有性別二態(tài)性。同時(shí)發(fā)現(xiàn)單胎新生兒AGD大于雙胎新生兒AGD,胎齡、出生體重、出生身長(zhǎng)與新生兒AGD呈正相關(guān),其中出生體重可能是新生兒AGD重要的影響因素。本研究的測(cè)量方法簡(jiǎn)單、可靠,可重復(fù)性強(qiáng),易于推廣應(yīng)用,具有較大臨床意義。
[Abstract]:Background: anal genitalia distance (AGD) is an important indicator of human sexual development. At present, AGD is mainly used to measure malinization, to assess the level of intrauterine androgen exposure during pregnancy, and to study the relationship with cryptorchidism and hypospadias. To evaluate the reproductive ability of adult males. However, there are few studies on AGD in China, and there is no separate report on neonatal AGD measurement. Objective: to establish the normal reference value of AGD in term neonates and to explore the possible factors affecting neonatal AGD so as to provide reference for further study of the relationship between AGD and sexual development. Methods: 205 normal term newborns were selected from March 2017 to April 2017 in the third affiliated Hospital of Guangzhou Medical University, including 116 males and 89 females. All newborns were measured within 72 hours after birth with digital Vernier calipers. The AGD of male newborns was measured by three indexes: the distance from the anal center to the base of the scrotum, the distance from the anal center to the dorsal side of the penile base, and the distance between the anal center and the ventral base of the penis, and the distance between the anal center and the ventral base of the penis. The AGD of female newborns was measured by two indexes: the distance from the anal center to the posterior labia and the distance from the anal center to the clitoris. Each index is measured twice, with an average value of 0.1 mm. The result is 1: 1. The AGD values of male full-term newborns were 20. 6 鹵2. 9 mm: 1: 45.7 鹵3. 8 mm and 40. 0 鹵4. 4 mm. respectively. The AGD values of female full-term newborns were 12. 5 鹵2. 3 mm and 35. 5 鹵2. 1 mm. The AGD values of male and female full-term neonates were higher than that of female AFD(12.5 鹵2.3mm and 40.0 鹵4.4mm of AGD1(45.7 鹵3.8mm respectively, which were significantly higher than that of female's ACD(35.5 鹵2.1mm (P < 0.01). Compared with AGD of twin neonates, AGD of single born male neonates were higher than those of twin neonates (20.7 鹵2.9mm vs 18.4 鹵2.0 mm vs 46.0 鹵3.7mm vs 42.4 鹵1.8 mm vs 40.3 鹵4.4mm vs 36.4 鹵2.7 mm P, P < 0.05). The difference was statistically significant (P < 0.05). The results of Pearson correlation analysis showed that the gestational age was positively correlated with the gestational age and the age of ACD 0.212p 0.050 AFDR 0.276P0.05AFDR 0.270P0.05). There was a positive correlation between birth weight and ASD ru 0.232 (P 0.05), AGD1 (0.433), AGD2 (0.320) (P0.05), AFDR (0.288), ACDT (0.516), P0.05 (P 0.05), and ACDD _ (1) P _ (0.05) (P _ (0.05) P _ (0. 05) P _ (0.05) P _ (0.05). There was a positive correlation between the length of the birth and the ASD ru 0.162 P0.05 AGD1 / ACD1 / P0.05 / ACDD _ (0.24) / P _ (0.05) P _ (0.300) ~ (0.300) / AFDR ~ (0.246) / P ~ (0.05) ~ (0.24) / P ~ (0.05) / ACDD ~ (0.24) / P ~ (0.05) / ACDD ~ (0.24) / P ~ (0.05). There was no correlation between maternal factors (including conception age, weight before pregnancy, prenatal weight, weight gain during pregnancy, height of puerpera, BMI before pregnancy, first time of pregnancy, times of delivery) and neonatal AGD. Multiple stepwise regression analysis showed that birth weight may be an important influencing factor of neonatal AGD (尾 ASD: 0.232, 尾 AGD1: 0.433, 尾 AGD2: 0.320, 尾 AFDN: 0.288, 尾 ACDD: 0.516, P = 0.05). Conclusion: 205 normal term newborns were measured in this study, and the normal reference value of anal genital distance of term newborns was obtained. The results showed that the AGD of male newborns was higher than that of female neonates, which confirmed that AGD had gender dimorphism. At the same time, it was found that the AGD of single born neonates was higher than that of twin neonates, gestational age, birth weight and length of birth were positively correlated with neonatal AGD, among which birth weight may be an important influencing factor of neonatal AGD. The method is simple, reliable, reproducible and easy to be popularized and applied.
【學(xué)位授予單位】：廣州醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類(lèi)號(hào)】：R722.1

【參考文獻(xiàn)】

相關(guān)期刊論文 前2條

1 姜大朋;耿紅全;林厚維;于喜娜;張昕偉;楊書(shū)龍;王帥;;新生兒肛門(mén)生殖器距離與隱睪的相關(guān)性分析[J];中華男科學(xué)雜志;2015年05期

2 王恒友;唐達(dá)星;;人類(lèi)肛門(mén)生殖器距離測(cè)量的意義及研究進(jìn)展[J];中華小兒外科雜志;2013年02期

，

本文編號(hào)：1945975