本文選題：膿毒癥 + 血流感染�。� 參考：《中華醫(yī)院感染學雜志》2017年04期

【摘要】：目的探討膿毒癥血流感染患兒血清C-反應蛋白(CRP)、降鈣素原(PCT)水平變化及臨床診斷意義。方法選擇2010年1月-2016年6月醫(yī)院接診60例膿毒癥血流感染患兒為膿毒癥感染組,并選擇同期接診60例其余部位感染的患兒為對照組,比較兩組患兒血清CRP、PCT水平,PCT的測定使用免疫熒光雙抗體夾心法,CRP的測定使用膠體金法。結果膿毒癥血流感染患兒血清CRP(138.93±29.31)mg/L、PCT(13.21±1.87)ng/ml水平明顯高于對照組(47.34±9.84)mg/L、(0.31±0.05)ng/ml,差異有統(tǒng)計學意義(P0.05);革蘭陽性菌血流感染膿毒血癥患兒CRP(73.12±17.84)mg/L、PCT(2.31±0.44)ng/ml水平明顯低于革蘭陰性菌感染患兒(116.72±29.79)mg/L、(14.82±1.37)ng/ml,差異有統(tǒng)計學意義(P0.05);在革蘭陽性菌、革蘭陰性菌血流感染膿毒血癥患兒、其他所有血流感染膿毒血癥患兒均和CRP、PCT之間呈正相關(r=0.631,0.682,0.564;P0.05)。結論膿毒癥血流感染患兒CRP、PCT比其余部位感染的患兒表達水平更高,且革蘭陰性菌感染患兒CRP、PCT水平高于革蘭陽性菌感染患兒,在膿毒癥血流感染患兒中聯(lián)合檢測血清CRP、PCT具有較高的診斷價值,可為臨床診斷及治療提供可靠依據(jù),值得應用推廣。
[Abstract]:Objective to investigate the changes of serum C-reactive protein (CRP) and procalcitonin (procalcitonin) levels in children with septic blood stream infection and their clinical diagnostic significance. Methods from January 2010 to June 2016, 60 children with septic blood flow infection were selected as sepsis infection group, and 60 patients with other site infection were selected as control group. The serum levels of CRPnc-PCT and PCT were measured by immunofluorescence double antibody sandwich method and the level of CRP was determined by colloidal gold method. Results the levels of serum CRP(138.93 鹵29.31 mg / L PCT 13.21 鹵1.87)ng/ml in children with septic blood flow infection were significantly higher than those in the control group (47.34 鹵9.84 mg / ml, P < 0.05), and the levels of CRP(73.12 鹵17.84 mg / L CRP(73.12 / L ~ (2.31 鹵0.44)ng/ml) in children with septic sepsis were significantly lower than those in patients with Gram-negative bacterial infection (116.72 鹵29.79 mg / L, 14.82 鹵1.37 ng / ml, P < 0.05). In Gram-positive bacteria, There was a positive correlation between the blood flow infection of Gram-negative bacteria and CRPnPCT in children with sepsis of all other blood flow infections (P 0.05). Conclusion the expression of CRPnPCT in children with septic blood stream infection is higher than that in other infected children, and the level of CRPnPCT in Gram-negative bacteria infection is higher than that in Gram-positive infection. The combined detection of serum CRPnPCT in children with septic blood stream infection is of high diagnostic value and can provide reliable basis for clinical diagnosis and treatment.
【作者單位】： 杭州市余杭區(qū)中醫(yī)院兒科;杭州市第一人民醫(yī)院兒科;杭州市余杭區(qū)中醫(yī)院檢驗科;杭州市余杭區(qū)中醫(yī)院門診部;
【基金】：浙江省醫(yī)藥衛(wèi)生一般研究項目(201474125)
【分類號】：R720.597

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