本文選題：特發(fā)性中樞性性早熟 + 梔早顆粒��； 參考：《黑龍江中醫(yī)藥大學(xué)》2012年碩士論文

【摘要】：目的：通過分析ICPP女童血清BGP與其他因素之間的相關(guān)性,研究梔早顆粒對ICPP女童BGP的影響,并探討其延緩骨齡成熟進(jìn)程、改善患兒最終成人身高可能性作用機(jī)制。 方法：選取符合肝郁痰結(jié)型診斷標(biāo)準(zhǔn)的特發(fā)性中樞性性早熟女童46例,治療組25例,對照組21例。治療前對46例ICPP病例中影響血清BGP含量的相關(guān)因素進(jìn)行分析,兩組間一般資料進(jìn)行比較。治療組給予中藥梔早顆粒,1劑／日,分2次沖服；對照組給予抑那通每4周肌內(nèi)注射1次。療程6個月。治療前后及兩組間E2、T、GH、IGF-1、BGP、BA/CA等觀測指標(biāo)進(jìn)行比較。全部數(shù)據(jù)以均數(shù)±標(biāo)準(zhǔn)差(X±S)表示,BGP與其相關(guān)因素的采用pearson法和偏相關(guān)法進(jìn)行分析,組間比較采用Mann-Whitney秩和檢驗,治療前后比較采用Wilcoxon符號秩檢驗。分析均由SPSS16.0軟件包完成。 結(jié)果： 1.治療組與對照組病程、發(fā)病年齡、身高、體重、FSH、LH、子宮、卵巢體積之間均無差異性(P0.05)。2 2.采用pearson法對ICPP女童年齡、身高、體重、骨齡、血清BGP進(jìn)行相關(guān)性分析,各指標(biāo)均有顯著相關(guān)性(P0.01),采用偏相關(guān)法控制因素之間的影響后,只有血清BGP與骨齡呈相關(guān)(P0.01),血清BGP含量與年齡、身高、體重之間的相關(guān)性無統(tǒng)計學(xué)意義(P0.05)。 3.采用pearson法對ICPP女童血清E2、T、GH、IGF-1、BGP進(jìn)行相關(guān)性分析,血清GH、IGF-1、BGP三者間呈正相關(guān)(P0.01),E2與IGF-1呈正相關(guān)(P0.05),而E2與GH、BGP,T與GH、IGF-1、BGP之間的相關(guān)性無統(tǒng)計學(xué)意義(P0.05),采用偏相關(guān)法控制因素之間的影響后,只有血清IGF-1與BGP呈正性相關(guān)(P0.05),而血清E2、T、GH水平與BGP之間的相關(guān)性無統(tǒng)計學(xué)意義(P0.05)。 4.治療組、對照組患兒與治療前相比,療后血清E2、T、GH、IGF-1、BGP水平均有降低,治療前后比較有顯著性差異(P0.05)。治療前后兩組間血清E2、T、GH、IGF-1、BGP水平比較均無顯著性差異(P0.05)。 5.治療組與對照組治療前后骨齡比較均無統(tǒng)計學(xué)意義(P0.05),兩組治療后骨齡成熟的進(jìn)程均延緩(治療組1.14±0.10vs1.19±0.11,對照組1.14±0.12vs1.21±0.13),且治療前、治療后兩組間的比較均無顯著性差異(P0.05)。 結(jié)論： 1.特發(fā)性中樞性性早熟女童血清BGP水平與骨齡呈正性相關(guān),BGP可以反映骨齡成熟的程度。 2.特發(fā)性中樞性性早熟女童血清IGF-1水平與BGP呈正相關(guān),E2、GH可通過影響ICF-1生成的間接方式影響B(tài)GP生成,進(jìn)而影響患兒骨齡成熟的進(jìn)程。 3.梔早顆粒能夠降低ICPP患兒血清E2、T、GH、IGF1、BGP水平,改善性早熟患兒病情。 4.梔早顆�？赏ㄟ^降低ICPP患兒血清E2、GH、IF-1水平,下調(diào)BGP含量,延緩骨齡成熟的進(jìn)展,進(jìn)而改善ICPP患兒的最終成人身高情況。
[Abstract]:Objective: to study the effect of Zhizao granule on BGP of ICPP girls by analyzing the correlation between serum BGP and other factors in ICPP girls, and to explore the possible mechanism of delaying the maturation of bone age and improving the adult height of children. Methods: 46 cases of idiopathic central precocious puberty, 25 cases in treatment group and 21 cases in control group were selected. The related factors affecting serum BGP levels in 46 cases of ICPP were analyzed before treatment and the general data were compared between the two groups. The treatment group was given one dose of ZZG every day and the control group was given intramuscular injection of Yinatong once every 4 weeks. The course of treatment was 6 months. Before and after treatment and between the two groups, the observation indexes of IGF-1 BGPBA / CA were compared. All the data were analyzed by pearson method and partial correlation method with mean 鹵standard deviation X 鹵S, Mann-Whitney rank sum test and Wilcoxon sign rank test were used before and after treatment. The analysis was done by SPSS16.0 software package. Results: 1. There was no difference between treatment group and control group in course of disease, age of onset, height, weight of FSHLH, volume of uterus and ovary. 2. The age, height, weight, bone age and serum BGP of ICPP girls were analyzed by pearson method. Only serum BGP was correlated with bone age (P 0.01), and serum BGP content was not correlated with age, height and weight. 3. Pearson method was used to analyze the correlation of serum E2GP-TGHF-1BGP in girls with ICPP. There was a positive correlation between serum GHIGF-1BGP and IGF-1, while there was no significant correlation between E2 and GHGPGPT and GH IGF-1BGP (P0.05). After controlling the influence of the factors by partial correlation method, the results showed that there was no significant difference in the relationship between E2GP-T and IGF-1BGP in girls with ICPP, but there was no significant difference between E2 and BGPT and IGF-1BGP in serum of ICPP girls. There was a positive correlation between serum IGF-1 and BGP (P 0.05), but no significant correlation between serum E2T and BGP (P 0.05). 4. In the treatment group, compared with before treatment, the serum levels of serum E2T GH-IGF-1 BGP in the control group were lower than those before and after treatment, and there was a significant difference between before and after treatment (P 0.05). There was no significant difference in BGP levels between the two groups before and after treatment (P 0.05). 5. There was no significant difference in bone age between the treatment group and the control group before and after treatment (P 0.05). The process of bone age maturation was delayed after treatment in both groups (1.14 鹵0.10vs1.19 鹵0.11 in the treatment group and 1.14 鹵0.12vs1.21 鹵0.13 in the control group). There was no significant difference between the two groups before and after treatment (P 0.05). Conclusion: 1. Serum BGP level was positively correlated with bone age in idiopathic central precocious girls. 2. The serum IGF-1 level of idiopathic central precocious puberty girls was positively correlated with BGP. E2GH could influence BGP production through the indirect way of affecting ICF-1 production, and then affect the process of bone age maturation in children. 3. Zhizao granule can reduce the serum level of serum E2 ICPP and improve the condition of precocious puberty. 4. Zhizao granule can decrease the level of serum E2HG IF-1, down-regulate the content of BGP, delay the progress of bone age maturation, and improve the final adult height of ICPP children.
【學(xué)位授予單位】：黑龍江中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2012
【分類號】：R272

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