本文選題：腦利鈉肽 + c反應(yīng)蛋白　； 參考：《桂林醫(yī)學(xué)院》2015年碩士論文

【摘要】：目的觀察先天性心臟病(congenital heart disease,CHD)并心力衰竭(heart failure,HF)患兒血漿腦利鈉肽(Brain Natriuretic Peptide,BNP)和c反應(yīng)蛋白(CRP)水平的變化,分析BNP與HF嚴重程度的關(guān)系及在心功能評估中的價值。方法選擇本院2013年1月2014年8月在兒科和心胸外科住院的CHD患兒72例,根據(jù)改良ROSS評分的評價標準將其分成4組:無HF組(23例)、輕度HF組(21例)、中度HF組(18例)、重度HF組(10例)。選取同一時期在門診進行健康體檢的24例健康兒童作為對照組。分別通過標準程序抽取各組靜脈血2 m L,通過ELISA法測定各個實驗組的血漿BNP和CRP水平。通過統(tǒng)計學(xué)方法分析血漿BNP和CRP水平與心力衰竭嚴重程度的相關(guān)性。結(jié)果心力衰竭嚴重程度與血漿BNP水平明顯正相關(guān)(r=0.72,P0.05),血漿BNP水平隨著心力衰竭嚴重程度而升高;比較各實驗組發(fā)現(xiàn),中重度HF組血漿BNP水平顯著高于輕度HF組(P0.01),輕度HF組血漿BNP水平高于無HF組和健康對照組(P0.05)。結(jié)論心力衰竭嚴重程度越發(fā)嚴重,其患者血漿BNP水平越高,臨床上通過檢測血漿BNP對評估CHD合并HF患兒病情嚴重程度及判斷預(yù)后具有重大的臨床意義。
[Abstract]:Objective to observe the changes of plasma brain Natriuretic Peptidine (Natriuretic) and c-reactive protein (CRP) levels in children with congenital heart disease (CHD) and heart failure (HF), and to analyze the relationship between BNP and HF severity and its value in the evaluation of cardiac function. Methods Seventy-two cases of CHD in pediatrics and cardiothoracic surgery in our hospital were divided into 4 groups according to the evaluation criteria of modified ROSS score: no HF group (n = 23), mild HF group (n = 21), moderate HF group (n = 18) and severe HF group (n = 10). Twenty-four healthy children who underwent physical examination in outpatient clinic at the same time were selected as control group. The plasma BNP and CRP levels in each experimental group were measured by ELISA method. The correlation between plasma BNP and CRP levels and the severity of heart failure was analyzed statistically. Results there was a significant positive correlation between the severity of heart failure and the level of plasma BNP, and the level of plasma BNP increased with the severity of heart failure. The plasma BNP level in moderate and severe HF group was significantly higher than that in mild HF group (P 0.01). The plasma BNP level in mild HF group was higher than that in HF free group and healthy control group (P 0.05). Conclusion the severity of heart failure is more serious and the plasma BNP level is higher in patients with heart failure. It is of great clinical significance to evaluate the severity of the disease and to judge the prognosis of children with CHD by detecting plasma BNP in clinic.
【學(xué)位授予單位】：桂林醫(yī)學(xué)院
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：R725.4

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相關(guān)期刊論文 前1條

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本文編號：1891464