本文選題：荊杏止咳顆粒 + 小兒外感咳嗽��； 參考：《湖北中醫(yī)藥大學(xué)》2012年碩士論文

【摘要】：目的：本課題旨在研究荊杏止咳顆粒治療小兒外感咳嗽風(fēng)寒化熱證的有效性與安全性。 方法：本試驗(yàn)病例均來(lái)自于2009年10月到2010年6月于湖北省中醫(yī)院門診就診的患兒,按照西醫(yī)急性支氣管炎和中醫(yī)外感咳嗽風(fēng)寒化熱證的診斷標(biāo)準(zhǔn)從中篩選48例,按完全隨機(jī)的方法以1：1：1的比例分為高劑量組、中劑量組、極低劑量組,經(jīng)統(tǒng)計(jì)分析各組間病例在年齡、性別、病程方面無(wú)顯著差異,具有可比性。再分別予高、中、極低劑量荊杏止咳顆�？诜�,服用方法為3歲以上,每次1袋；6歲-14歲,每次2袋,溫開(kāi)水沖服,一日三次,5天為一個(gè)療程。療程結(jié)束后比較三組在疾病療效、主要癥候積分、癥候總積分、服藥后起效時(shí)間的差異性,并通過(guò)觀察入選病例治療前后血常規(guī)、尿常規(guī)、糞常規(guī)及心電圖、肝、腎功能及出現(xiàn)的不良反應(yīng)以評(píng)價(jià)其安全性。 結(jié)果： 1.治療后有效率比較：高、中劑量組總有效率93.75%,極低劑量組總有效率31.25%,高、中劑量組與極低劑量組比較均有顯著差異(P0.05)。中劑量組與高劑量組總有效率比較,P0.05,差異無(wú)統(tǒng)計(jì)學(xué)意義；高劑量組的臨床痊愈率優(yōu)于中劑量組,但差異不具有統(tǒng)計(jì)學(xué)意義(P0.05)。 2.主要癥候積分比較：主要癥候積分(咳嗽、肺部聽(tīng)診、咯痰)治療前組間比較,高、中、極低劑量組比較無(wú)顯著性差異(P0.05),具有可比性。治療前后比較,高、中劑量組均有顯著性差異(P0.05),治療后明顯優(yōu)于治療前,極低劑量組治療前后比較無(wú)顯著性差異(P0.05)。治療后三組組間比較,高、中劑量組與極低劑量組比較均具有顯著差異(P0.05)；高劑量組與中劑量組比較P0.05,差異不具有統(tǒng)計(jì)學(xué)意義 3.癥候總積分比較：癥候總積分治療前高、中、極低劑量組比較無(wú)顯著性差異(P0.05),具有可比性。高、中、極低劑量組組內(nèi)治療前后比較有顯著性差異(P0.05),治療后明顯優(yōu)于治療前。治療后三組組間比較,高、中劑量組與極低劑量組比較均具有顯著差異(P0.05)；高劑量組與中劑量組比較差異不具有統(tǒng)計(jì)學(xué)意義(P0.05)。治療前后總積分差值組間比較,高、中劑量組與極低劑量組比較差異均具有顯著差異(P0.05),高、中劑量組間比較差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。 4.三組起效時(shí)間比較：高、中、極低劑量組三組在服藥后起效時(shí)間的差異有統(tǒng)計(jì)學(xué)意義,高劑量組優(yōu)于中劑量組,中劑量組優(yōu)于極低劑量組。 5.治療前后三組血、尿、糞常規(guī)、心電圖、肝功能、腎功能均未出現(xiàn)異常,未發(fā)現(xiàn)不良反應(yīng)的情況。 結(jié)論：極低劑量荊杏止咳顆粒治療小兒外感咳嗽效果欠佳。高、中劑量荊杏止咳顆粒治療小兒外感咳嗽效果確切,療效滿意；二者在疾病總有效率、改善癥候方面無(wú)顯著差異,但起效時(shí)間高劑量組優(yōu)于中劑量組,安全可靠,具有廣泛的應(yīng)用前景,值得進(jìn)一步深入研究推廣
[Abstract]:Objective : To study the efficacy and safety of Jingxing Zhike Granule in treating infantile cough due to cough .

Methods : From October 2009 to June 2010 in Hubei Province , 48 cases were screened according to the diagnostic criteria of acute bronchitis and cough wind - cold syndrome in Hubei Province .
After treatment , three groups were divided into three groups : treatment effect , main symptom score , total score of syndrome , time difference after taking medicine , and the safety was evaluated by observing the routine , routine , routine and electrocardiogram , liver , renal function and adverse reaction of the patients before and after the treatment .

Results :

1 . After treatment , the total effective rate was 93.75 % , the total effective rate of the low - dose group was 31.25 % , the total effective rate of the low - dose group was 31.25 % , and the total effective rate in the middle - dose group was significantly higher than that in the low - dose group ( P0.05 ) .
The clinical cure rate of the high - dose group was better than that in the middle - dose group , but the difference was not statistically significant ( P0.05 ) .

2 . There was no significant difference between the two groups ( P0.05 ) . There was no significant difference between the two groups ( P0.05 ) .
There was no significant difference between the high dose group and the middle dose group ( P0.05 ) .

3 . There was no significant difference between the two groups ( P0.05 ) . There was a significant difference between the two groups ( P0.05 ) .
There was no significant difference between the high and middle dose groups ( P0.05 ) . There was no significant difference between the two groups ( P0.05 ) .

4 . The effect time of three groups was higher than that in the middle and low dose groups . The high dose group was superior to the middle dose group , and the middle dose group was superior to the extremely low dose group .

5 . Before and after treatment , three groups of blood , urine , feces routine , electrocardiogram , liver function , renal function were not abnormal , no adverse reaction was found .

Conclusion : The effect of low dose of Jingxing Zhike Granule on cough in children is not good . The effect of high and medium dose of Jingxing Zhike Granule on cough in children is exact and the curative effect is satisfactory .
Both have no significant difference in the total effective rate and the improvement symptoms of the disease , but the effective time high - dose group is superior to the middle - dose group , is safe and reliable , has wide application prospect , and is worthy of further research and popularization .

【學(xué)位授予單位】：湖北中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2012
【分類號(hào)】：R272

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