本文選題：波生坦 + 西地那非　； 參考：《中國醫(yī)院藥學(xué)雜志》2017年04期

【摘要】：目的:探討波生坦聯(lián)合西地那非治療先天性心臟病合并肺動(dòng)脈高壓患兒的臨床療效及不良反應(yīng)發(fā)生情況。方法:選擇2015年1月到2016年1月某院收治的90例先天性心臟病合并肺動(dòng)脈高壓患兒,隨機(jī)分為對(duì)照組和試驗(yàn)組,各45例。對(duì)照組患兒給予西地那非治療,試驗(yàn)組患兒給予波生坦聯(lián)合西地那非治療,兩組患兒均治療3個(gè)月。評(píng)價(jià)并比較兩組患兒的臨床療效。檢測并比較兩組患兒治療前后WHO肺動(dòng)脈高壓功能分級(jí)。采用右心導(dǎo)管檢測測量并比較兩組患兒治療前后平均肺動(dòng)脈壓(m PAP)和肺血管阻力(PVR)。觀察并比較兩組患兒治療期間不良反應(yīng)的發(fā)生情況。結(jié)果:治療后,試驗(yàn)組患兒的總有效率為95.56%,明顯高于對(duì)照組患兒的73.33%,差異具有統(tǒng)計(jì)學(xué)意義(χ~2=8.46,P=0.003 6)。治療前,兩組WHO肺動(dòng)脈高壓功能分級(jí)比較差異無統(tǒng)計(jì)學(xué)意義(P0.05);治療后,兩組WHO肺動(dòng)脈高壓功能Ⅱ級(jí)患兒均明顯多于治療前,WHO肺動(dòng)脈高壓功能Ⅲ級(jí)、Ⅳ級(jí)患兒均明顯少于治療前,差異均具有統(tǒng)計(jì)學(xué)意義(P0.05),同時(shí)試驗(yàn)組WHO肺動(dòng)脈高壓功能Ⅱ級(jí)患兒均明顯多于對(duì)照組,WHO肺動(dòng)脈高壓功能Ⅲ級(jí)、Ⅳ級(jí)患兒均明顯少于對(duì)照組,差異均具有統(tǒng)計(jì)學(xué)意義(P0.05)。治療前,兩組患兒的m PAP、PVR比較,差異均無統(tǒng)計(jì)學(xué)意義(P0.05);治療后,兩組患兒的m PAP、PVR均明顯小于治療前,并且試驗(yàn)組患兒的m PAP、PVR均明顯小于對(duì)照組,差異均具有統(tǒng)計(jì)學(xué)意義(P0.05)。治療期間,兩組患兒的不良反應(yīng)發(fā)生率比較,差異無統(tǒng)計(jì)學(xué)意義(χ~2=1.01,P=0.908)。結(jié)論:波生坦聯(lián)合西地那非治療先天性心臟病合并肺動(dòng)脈高壓患兒臨床療效顯著,且安全性較好,值得在臨床上推廣應(yīng)用。
[Abstract]:Objective: to investigate the clinical efficacy and adverse reactions of Bosentan combined with sildenafil in the treatment of children with congenital heart disease complicated with pulmonary hypertension. Methods: from January 2015 to January 2016, 90 children with congenital heart disease complicated with pulmonary hypertension were randomly divided into control group and experimental group with 45 cases each. Patients in the control group were treated with sildenafil, and those in the experimental group were treated with Bosentan combined with sildenafil for 3 months. To evaluate and compare the clinical efficacy of the two groups. The functional grades of WHO pulmonary hypertension before and after treatment were detected and compared between the two groups. Right cardiac catheterization was used to measure and compare the mean pulmonary artery pressure (MPP) and pulmonary vascular resistance (PVR) before and after treatment. To observe and compare the occurrence of adverse reactions during treatment in two groups. Results: after treatment, the total effective rate of the test group was 95.566.It was significantly higher than that of the control group (73.33%), and the difference was statistically significant (蠂 ~ 2 + 8.46%, P < 0.0036). Before treatment, there was no significant difference in functional grading of WHO pulmonary hypertension between the two groups (P 0.05). After treatment, the number of WHO pulmonary hypertension grade 鈪，

本文編號(hào)：1845744