本文選題：橋本氏甲狀腺炎伴Hp感染 + 血清�。� 參考：《中華醫(yī)院感染學(xué)雜志》2017年19期

【摘要】：目的研究與觀察橋本氏甲狀腺炎伴幽門(mén)螺桿菌(Hp)感染患兒的血清白細(xì)胞介素17(IL-17)、脂聯(lián)素(APN)水平及Toll樣受體(TLR)蛋白表達(dá)變化情況。方法選取2013年2月-2016年10月醫(yī)院收治的69例橋本氏甲狀腺炎伴Hp感染患兒為A組,69例橋本氏甲狀腺炎患兒為B組,69例Hp感染患兒為C組,69名健康兒童為D組,將四組血清IL-17、APN水平及TLR蛋白指標(biāo)進(jìn)行比較,同時(shí)比較A、B組中不同橋本氏甲狀腺炎分期患兒,A、C組中不同Hp分型患兒的上述指標(biāo)檢測(cè)結(jié)果。結(jié)果 A組的血清IL-17、APN水平及TLR蛋白指標(biāo)(TLR2及TLR9)分別為(10.25±1.34)ng/L、(11.15±1.36)mg/L、(5.86±0.64)ng/ml及(19.84±2.68)ng/ml,均高于B組(7.91±0.95)ng/L、(8.90±0.93)mg/L、(3.91±0.34)ng/ml、(11.02±1.93)ng/ml,C組的(7.80±0.93)ng/L、(8.87±0.90)mg/L、(3.78±0.31)ng/ml、(10.84±1.89)ng/ml及D組的(5.76±0.45)ng/L、(6.95±0.73)mg/L、(2.02±0.23)ng/ml、(5.56±0.60)ng/ml,B組及C組均高于D組,且A、B兩組中不同橋本氏甲狀腺炎分期患兒的血清IL-17、APN水平及TLR蛋白指標(biāo)表達(dá)水平存在顯著性差異,A、C兩組中不同Hp分型患兒的上述指標(biāo)檢測(cè)結(jié)果也存在顯著性差異(P均0.05)。結(jié)論橋本氏甲狀腺炎伴Hp感染患兒的血清IL-17、APN水平及TLR蛋白指標(biāo)表達(dá)呈現(xiàn)明顯異常狀態(tài),且橋本氏甲狀腺炎分期與Hp分型均對(duì)其表達(dá)有較大的影響,應(yīng)重視對(duì)上述指標(biāo)的監(jiān)測(cè)與改善。
[Abstract]:Objective to study the changes of serum interleukin-17 (IL-17) and adiponectin (APN) levels and the expression of Toll like receptor (TLR) protein in children with Hashimoto's thyroiditis complicated with Helicobacter pylori (HP) infection. Methods 69 cases of Hashimoto's thyroiditis with HP infection were selected from February 2013 to October 2016. 69 cases of Hashimoto's thyroiditis were selected as group A and 69 cases of HP infection in group B and 69 healthy children in group C as group D. The serum IL-17 APN levels and TLR protein levels were compared among the four groups, and the results were compared among the patients with different Hashimoto's thyroiditis stages and different HP typing in group A (P < 0.05). 緇撴灉 A緇勭殑琛，

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