本文選題：氟化合物 + 肺��； 參考：《中國學(xué)校衛(wèi)生》2017年07期

【摘要】：目的探討全氟化合物對哮喘兒童和一般兒童肺功能影響的性別差異,為采取有效措施保護(hù)兒童心肺功能提供參考。方法從臺灣大學(xué)醫(yī)院就診的哮喘兒童選取132名,從臺北地區(qū)7所公立中學(xué)隨機(jī)選取168名一般健康兒童。采用Logistic回歸和多重線性回歸的方法分析血清全氟辛烷磺酸(perfluorooctanesulfonate,PFOS)和全氟辛酸(perfluorooctanoic acid,PFOA)水平對兒童肺功能的影響。結(jié)果兒童哮喘的患病風(fēng)險隨著全氟化合物(perfluoroalkyl and polyfluoroalkyl substances,PFAAS)濃度的增加而呈現(xiàn)增高趨勢,PFOS與PFOA暴露對兒童哮喘患病風(fēng)險的優(yōu)勢比分別為1.32(95%CI=1.02~1.71)和2.80(95%CI=1.87~4.20)。PFOS和PFOA暴露水平與哮喘男童的肺功能水平(FVC,FEV_1和FEF_(25%~75%))呈負(fù)相關(guān),男孩血清中PFOS和PFOA水平每增加1μg/L時,FEV_1分別下降-0.062(95%CI=-0.106~-0.018)和-0.099(95%CI=-0.197~-0.001)L。結(jié)論 PFAAs的暴露可以降低兒童肺功能水平,并且男童相較于女童更易感。
[Abstract]:Objective to explore the effect of perfluorocarbons on lung function in asthmatic children and general children, and to provide reference for effective measures to protect children's cardiopulmonary function. Methods 132 asthmatic children were selected from Taiwan University Hospital and 168 healthy children were randomly selected from 7 public middle schools in Taipei area. The effects of serum perfluorooctanesulfonate (PFOS) and perfluorooctanoic acid (PFOAA) levels on children's lung function were analyzed by Logistic regression and multiple linear regression. Results the risk of asthma in children increased with the increase of perfluoroalkyl and polyfluoroalkyl substancesPFAAS. the odds ratio between PFOS and PFOA exposure to childhood asthma risk was 1.3295 CI 1.02C 1.71), and the exposure levels of 2.80(95%CI=1.87~4.20).PFOS and PFOA were higher than those of asthmatic boys. There was a negative correlation between the level of pulmonary function and the FEFC number of FEV1. When the serum levels of PFOS and PFOA increased by 1 渭 g / L in boys, FEV _ 1 decreased -0.062 ~ (95) CI ~ (-0.106) ~ (-0.018) and -0.099 ~ 95% ~ (-0.197) ~ (-0.001) L ~ (-1) respectively. Conclusion exposure to PFAAs can reduce pulmonary function in children, and boys are more susceptible than girls.
【作者單位】： 廣東省廣州市中小學(xué)衛(wèi)生健康促進(jìn)中心;中山大學(xué)公共衛(wèi)生學(xué)院預(yù)防醫(yī)學(xué)系;臺灣大學(xué)公共衛(wèi)生學(xué)院;
【基金】：國家自然科學(xué)基金項(xiàng)目(81472936) 廣東省自然科學(xué)基金項(xiàng)目(2014A030313021)
【分類號】：R725.6
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本文編號：1828504