本文選題：幽門螺桿菌 + 流行病學(xué)��； 參考：《臨床兒科雜志》2017年10期

【摘要】：目的系統(tǒng)評價中國兒童及青少年幽門螺桿菌(H.pylori)感染的流行病學(xué)特征。方法檢索Pub Med、EMBASE、Cochrane圖書館、中國知網(wǎng)、萬方數(shù)據(jù)庫,檢索起止時間為建庫至2016年9月。2名研究者根據(jù)納入與排除標準篩選文獻,采用AHRQ量表評估文獻質(zhì)量,使用Stata 12.0軟件進行meta分析。結(jié)果 7篇文獻納入meta分析,涉及16 950名兒童及青少年。中國自然人群兒童及青少年H.pylori總感染率為29%(95%CI:0.18~0.40);兒童及青少年H.pylori感染呈顯著的地域分布性差異,在胃癌低發(fā)區(qū),中國自然人群兒童H.pylori總感染率為20%(95%CI:0.13~0.28),在胃癌高發(fā)區(qū)H.pylori總感染率高達55%(95%CI:0.21~0.89);男性與女性H.pylori感染率無顯著差異;≤1歲、~5歲、~10歲、~15歲、~18歲兒童及青少年的H.pylori感染率分別為17.8%、8%、19%、26%、45%,隨年齡增長H.pylori感染率有上升趨勢;農(nóng)村兒童及青少年H.pylori感染風(fēng)險是城市的1.25倍;有消化道癥狀的農(nóng)村兒童及青少年H.pylori感染風(fēng)險比無消化道癥狀者高2.2倍。結(jié)論中國自然人群兒童及青少年H.pylori總感染率為29%,呈現(xiàn)顯著的地域分布性差異,胃癌高發(fā)區(qū)H.pylori感染率是胃癌低發(fā)區(qū)的2.8倍。仍需后續(xù)高質(zhì)量、大樣本量流行病學(xué)調(diào)查,以進一步明確中國兒童及青少年H.pylori感染情況。
[Abstract]:Objective to evaluate the epidemiological characteristics of H. pylori infection in Chinese children and adolescents.Methods the Pub Medbin EMBASE Cochrane Library, China knowledge Network and Wanfang database were searched. The literature quality was evaluated by AHRQ scale according to the inclusion and exclusion criteria from the beginning to the end of the database construction until September 2016.Meta analysis was carried out with Stata 12.0 software.Results Seven articles were included in meta analysis, involving 16 950 children and adolescents.The total infection rate of H.pylori in children and adolescents of natural population in China was 2995 CI: 0.180.400.The distribution of H.pylori infection in children and adolescents was significant difference in the low incidence area of gastric cancer.The total infection rate of H.pylori in Chinese natural population was 20 / 95. The total infection rate of H.pylori was as high as 55 ~ 95CI: 0.21 ~ 0.89 in the area with high incidence of gastric cancer. There was no significant difference between male and female in H.pylori infection rate.The infection rate of H.pylori in children and adolescents aged 15 and 18 years old was 17.80.The infection rate of H.pylori increased with the increase of age, and the risk of H.pylori infection in rural children and adolescents was 1.25 times higher than that in urban areas.The risk of H.pylori infection in rural children and adolescents with digestive tract symptoms was 2.2 times higher than that without gastrointestinal symptoms.Conclusion the total infection rate of H.pylori in children and adolescents of Chinese natural population is 29, showing significant regional distribution difference. The H.pylori infection rate in the high incidence area of gastric cancer is 2.8 times higher than that in the low incidence area of gastric cancer.High quality and large sample epidemiological investigation is still needed to further clarify the H.pylori infection in Chinese children and adolescents.
【作者單位】： 蘭州大學(xué)第一臨床醫(yī)學(xué)院;甘肅省胃腸病重點實驗室;蘭州大學(xué)第二醫(yī)院;
【基金】：國家自然科學(xué)基金面上項目(No.81372145) 蘭州大學(xué)中央高�；究蒲袠I(yè)務(wù)費專項資金(No.lzujbky-2013-157) 蘭州大學(xué)第一醫(yī)院院內(nèi)基金(No.ldyyynqn201203)
【分類號】：R725.7

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