本文選題：過敏性紫癜 + 兒童��； 參考：《昆明醫(yī)科大學(xué)》2017年碩士論文

【摘要】：[目的]:通過測(cè)定過敏性紫癜(Henoch-Schonlein Purpura, HSP)患兒急性期,HSP患兒恢復(fù)期和正常兒童組血漿中5-羥色胺(5-HT)、P-物質(zhì)(SP)、血管活性腸肽(VIP)和胃泌素(GAS)的水平變化,以便更好地認(rèn)識(shí)HSP患兒的腸神經(jīng)內(nèi)分泌的變化和發(fā)病機(jī)制。[方法]:選擇2015年5月～2015年9月昆明醫(yī)科大學(xué)第一附屬醫(yī)院收治的HSP患兒40例(其中急性期組30例,恢復(fù)期租10例)為研究組,取某昆明市小學(xué)正常自愿者學(xué)生30名為對(duì)照組;研究組分為急性期組30例(單純型10例,腹型10例,其他型10例)和恢復(fù)期組10例。采用放射免疫法檢測(cè)HSP患兒40例和某小學(xué)對(duì)照組兒童30例血漿中SP、VIP及GAS水平;采用雙抗體夾心酶聯(lián)免疫吸附(ELISA)法測(cè)定其血漿中5-HT水平。所有數(shù)據(jù)經(jīng)統(tǒng)計(jì)學(xué)方法處理。[結(jié)果]:HSP急性期組患兒血漿中5-HT、SP、VIP含量較對(duì)照組和HSP恢復(fù)期組兒童升高(P0.05),HSP恢復(fù)期組與對(duì)照組比較無差異(P0.05);HSP急性期組患兒血漿中GAS含量較對(duì)照組和HSP恢復(fù)期組兒童降低(P0. 05),HSP恢復(fù)期組與對(duì)照組比較無差異(P0. 05) ; HSP患兒?jiǎn)渭冃�、腹型和其他型血漿中5-HT、SP、VIP及GAS含量組間比較無差異(P0. 05)。[結(jié)論]:1. HSP急性期組較正常兒童組與HSP恢復(fù)期組患兒血漿中5-HT、SP、VIP含量明顯上升,GAS含量明顯下降,HSP恢復(fù)期較正常兒童組患兒血漿中5-HT、SP、VIP、GAS含量無明顯差異。提示VIP、SP、5-HT、GAS可能通過腸神經(jīng)內(nèi)分泌的變化參與了HSP的發(fā)病機(jī)制。2.HSP急性期組患兒血漿5-HT、SP、VIP、GAS含量在單純型、腹型和其他型間比較,無明顯變化。
[Abstract]:[objective]: to determine the plasma levels of 5-hydroxytryptamine 5-HTP- (P), vasoactive intestinal peptide (VIPs) and gastrin (gastrin) in children with Henoch-Schonlein Purpura (HSPs) in the acute stage of HSP2 and in normal children, and to determine the changes of plasma levels of 5-hydroxytryptophan (5-HT) in patients with Henoch-Schonlein Purpura (HSPs).In order to better understand the changes of intestinal neuroendocrine and pathogenesis in children with HSP.[methods] from May 2015 to September 2015, 40 children with HSP were selected from the first affiliated Hospital of Kunming Medical University as the study group (30 cases in the acute stage group and 10 cases in the recovery period), and 30 normal volunteers in a Kunming primary school as the control group.The study group was divided into acute group (n = 30) (simple type 10 cases, abdominal type 10 cases, other type 10 cases) and recovery group (10 cases).The plasma levels of HSP and GAS were measured by radioimmunoassay in 40 children with HSP and 30 children with primary school control, and the levels of 5-HT in plasma were measured by double antibody sandwich enzyme linked immunosorbent assay (Elisa).All data were processed statistically.[results] compared with the control group and the HSP convalescence group, there was no difference in the plasma GAS content between the two groups. The plasma GAS content in the acute stage group was lower than that in the control group and HSP recovery group. [results] the level of GAS in the plasma of the children in the acute stage group was higher than that in the control group and the HSP group in the convalescent period group. The content of GAS in the plasma of the patients in the acute phase group was lower than that in the control group and the HSP recovery group.There was no difference between the group of 05 and the control group in the recovery period of HSP (P 0. 0).There was no significant difference in the plasma levels of 5-HTP and GAS between simple type, abdominal type and other type of HSP patients (P 0. 05).05.[conclusion]: 1.There was no significant difference in the concentration of 5-HTP HSP in plasma between the acute phase of HSP and the normal children and the convalescent group of HSP. The content of gas in plasma of the acute phase of HSP was significantly lower than that of the normal children. There was no significant difference in the content of 5-HTG and VIPGAS in the plasma of the patients in the acute phase of HSP and in the convalescent group of HSP.It is suggested that the changes of intestinal neuroendocrine may be involved in the pathogenesis of HSP. 2. There is no significant change in plasma 5-HTP VIPGAS content between simple type, abdominal type and other types in patients with acute stage of HSP.
【學(xué)位授予單位】：昆明醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R725.5

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本文編號(hào)：1760056