本文選題：蘇神方 + 輪狀病毒腸炎�。� 參考：《廣州中醫(yī)藥大學(xué)》2017年碩士論文

【摘要】：目的:通過(guò)平行設(shè)計(jì)隨機(jī)對(duì)照實(shí)驗(yàn),運(yùn)用中藥特色復(fù)方治療輪狀病毒腸炎,觀察余德釗教授的經(jīng)驗(yàn)方蘇神方對(duì)兒童輪狀病毒腸炎的臨床療效及其對(duì)主要癥狀體征的改善情況,為小兒輪狀病毒腸炎的治療提供更安全有效的選擇。方法:本實(shí)驗(yàn)按照小兒輪狀病毒腸炎的中醫(yī)及西醫(yī)診斷標(biāo)準(zhǔn),共納入60例患兒,通過(guò)應(yīng)用平行設(shè)計(jì)隨機(jī)對(duì)照實(shí)驗(yàn),將60例患兒分為治療組與對(duì)照組2組,每組30例。對(duì)照組給予口服補(bǔ)液鹽、蒙脫石散治療;治療組在對(duì)照組的基礎(chǔ)上,給予口服蘇神方治療。觀察兩組患兒的總有效率、退熱時(shí)間、止瀉時(shí)間、中醫(yī)臨床證候量化積分及其他次要癥狀的改善情況,考察蘇神方對(duì)小兒輪狀病毒腸炎的治療作用及優(yōu)勢(shì)。結(jié)果:1.治療后,治療組患兒的總有效率為93.33%,對(duì)照組患兒總有效率為66.67%,經(jīng)Mann-Whitney U檢驗(yàn),兩組療效比較有顯著性差異(Mann-Whitney U=250.00,P=0.000.05);經(jīng)Fisherχ2檢驗(yàn),治療組的總有效率優(yōu)于對(duì)照組,差異存在顯著統(tǒng)計(jì)學(xué)意義(χ2=0.58,P=0.020.05)。2.治療前,治療組和對(duì)照組在中醫(yī)臨床證候量化總積分的比較,經(jīng)方差齊性檢驗(yàn),方差齊(P=0.53,P=0.470.05),經(jīng)獨(dú)立樣本t檢驗(yàn),治療組患兒中醫(yī)臨床證候量化積分無(wú)顯著性差異(t=-0.39,P=0.690.05),具有可比性。治療后,經(jīng)方差齊性檢驗(yàn),方差不齊(F=13.59,P=0.000.05),經(jīng)獨(dú)立樣本t'檢驗(yàn),治療組患兒中醫(yī)臨床證候量化積分有顯著性差異(t'=-3.48,P=0.000.05)。治療前后的差值方面,經(jīng)方差齊性檢驗(yàn),方差齊(F=1.48,P=0.230.05),經(jīng)獨(dú)立樣本t檢驗(yàn),治療組患兒中醫(yī)臨床證候量化積分有顯著性差異(t=4.32,P=.000.05),提示治療組患兒中醫(yī)臨床證候改善情況優(yōu)于對(duì)照組。治療組治療前后中醫(yī)臨床證候量化積分有顯著性差異(t=19.57,P=0.000.05);對(duì)照組治療前后中醫(yī)臨床證候量化積分有顯著性差異(t=10.57,P=0.000.05)提示治療組和對(duì)照組的治療均可改善中醫(yī)臨床證候。3.在退熱方面,治療組和對(duì)照組的退熱時(shí)間,經(jīng)方差齊性檢驗(yàn),方差不齊(F=9.08,P=0.000.05),經(jīng)獨(dú)立樣本t'檢驗(yàn),治療組患兒退熱時(shí)間有顯著性差異(t'=-4.59,P=0.000.05),提示治療組在退熱時(shí)間方面較對(duì)照組具有明顯的優(yōu)勢(shì)。4.在止瀉方面,治療組和對(duì)照組的止瀉時(shí)間,經(jīng)方差齊性檢驗(yàn),方差齊(F=0.04,P=0.850.05),經(jīng)獨(dú)立樣本t檢驗(yàn),治療組患兒止瀉時(shí)間有顯著性差異(t=-4.14,P=0.000.05),提示治療組在止瀉時(shí)間方面較對(duì)照組具有明顯的優(yōu)勢(shì)。5.治療后,在食欲不振方面,治療組評(píng)分經(jīng)McNemar檢驗(yàn),相比治療前具有顯著性差異(P=0.000.05);對(duì)照組評(píng)分經(jīng)McNemar檢驗(yàn),相比治療前無(wú)顯著性差異(P=0.130.05);兩組間食欲不振的癥狀經(jīng)Fisherχ2檢驗(yàn)比較,差異有統(tǒng)計(jì)學(xué)意義(χ2=5.01,P=0.040.05),提示治療組和對(duì)照組在治療后,食欲不振的癥狀均得到改善,但是治療組的改善情況較對(duì)照組具有明顯的優(yōu)勢(shì)。6.治療后,在惡心嘔吐方面,治療組經(jīng)McAeemar檢驗(yàn),相比治療前具有顯著性差異(P=0.000.05);對(duì)照組經(jīng)McNemar檢驗(yàn),相比治療前具有顯著性差異(P=0.010.05);兩組間惡心嘔吐的癥狀經(jīng)Fisher χ2檢驗(yàn)比較,差異無(wú)統(tǒng)計(jì)學(xué)意義(χ2 = 1.38,P=0.280.05),提示治療組和對(duì)照組在治療后,惡心嘔吐的癥狀均得到改善,且治療組的改善情況較對(duì)照組并無(wú)明顯的優(yōu)勢(shì)。7.治療結(jié)束后,兩組患兒均無(wú)明顯不良反應(yīng)出現(xiàn)。結(jié)論:通過(guò)中醫(yī)特色治療,蘇神方可顯著提高治療患兒的總有效率,迅速緩解輪狀病毒腸炎患兒的相關(guān)臨床癥狀,縮短病程,減少發(fā)熱時(shí)間、腹瀉時(shí)間,同時(shí),中醫(yī)相關(guān)臨床癥候得到明顯改善,此外,尚可有效減少病程后期患兒食欲不振、惡心嘔吐等情況,為小兒胃腸道系統(tǒng)的恢復(fù)和免疫系統(tǒng)的重新建立提供可能,降低繼發(fā)其他胃腸系統(tǒng)疾病的風(fēng)險(xiǎn),臨床價(jià)值較高,值得推廣。
[Abstract]:Objective: through the design of parallel randomized controlled trials, using the characteristics of traditional Chinese medicine compound in the treatment of rotavirus enteritis, observe the clinical curative effect of the experience of Professor Yu Dezhao, Su God of children rotavirus enteritis and its improvement on the main symptoms and signs, provide a safe and effective alternative for treatment of rotavirus enteritis in children. Methods: according to the experiment of traditional Chinese medicine and Western medicine diagnostic criteria of rotavirus enteritis, 60 cases were included, through the application of parallel design, randomized controlled trial, 60 patients were randomly divided into treatment group and control group 2 groups, 30 cases in each group. The control group was given oral rehydration salts, Montmorillonite powder treatment; the treatment group in the control group on the basis of God, give oral Su treatment. The efficiency of the total, observed two groups of children with fever time, antidiarrheal time, improve the situation of TCM clinical syndrome quantitative integral and other minor symptoms, Su God for children study The treatment effect and advantage of rotavirus enteritis. Results: 1. after treatment, the total effective rate in treatment group was 93.33%, control group total effective rate was 66.67%, by Mann-Whitney U test, two groups had significant difference (Mann-Whitney, U=250.00, P=0.000.05); the Fisher 2 test, the treatment group the total efficiency is better than the control group, the differences were statistically significant (2=0.58, P=0.020.05).2. before treatment, the treatment group and control group in TCM clinical syndrome quantitative total score, by variance homogeneity test, Fang Chaqi (P=0.53, P=, 0.470.05) with independent sample t test, the treatment group with TCM syndrome symptom score had no significant difference (t=-0.39, P=0.690.05), comparable. After treatment, the difference of homogeneity test of homogeneity of variance (F=13.59, P=0.000.05), with independent sample t'test, the treatment group with TCM syndrome score was significant The difference (t'=-3.48, P=0.000.05). The difference before and after treatment, by variance homogeneity test of variance (F=1.48, P=0.230.05), with independent sample t test, the treatment group with TCM syndrome score had significant difference (t=4.32, P=.000.05), indicating that the treatment group clinical syndromes of TCM were better than that of the control group. The treatment group before and after treatment of TCM clinical syndrome quantitative integral had significant difference (t=19.57, P=0.000.05); the control group before and after treatment of TCM syndrome score had significant difference (t=10.57, P=0.000.05) prompt treatment group and control group in the treatment of Chinese medicine can improve the clinical syndrome of.3. in the fever, and the treatment group the control group of the pyretolysis time, by variance homogeneity test of variances (F=9.08, P=0.000.05), with independent sample t'test, the treatment group in pyretolysis time had significant difference (t'=-4.59, P=0.000.05), suggesting that the pyretolysis Time has the advantage of.4. in diarrhea than the control group, diarrhea treatment group and control group, by variance homogeneity test, Fang Chaqi (F=0.04, P=0.850.05), with independent sample t test, the treatment group of children with diarrhea time had significant difference (t=-4.14, P=, 0.000.05), the treatment group in time of diarrhea as compared with the control group,.5. treatment has the advantage of obvious, in the loss of appetite, the treatment group were tested by McNemar, compared with before treatment with significant difference (P=0.000.05); the control group were tested by McNemar, compared with before treatment there was no significant difference between the two groups (P=0.130.05); anorexia symptoms by Fisher 2 test comparison, the difference was statistically significant (2=5.01, P=0.040.05), the treatment group and control group after treatment, the symptoms of anorexia were improved, but the improvement in the treatment group than the control group has the obvious advantages of.6. After treatment, nausea and vomiting in the treatment group, by McAeemar test, compared with before treatment with significant difference (P=0.000.05); the control group by McNemar test, compared with before treatment with significant difference (P=0.010.05) between the two groups; nausea and vomiting symptoms by Fisher 2 test was compared, the difference was not statistically significant (x 2 = 1.38, P=0.280.05), the treatment group and control group after treatment, the symptoms of nausea and vomiting were improved, the improvement of the treatment group than in the control group had no obvious advantage over.7. after treatment, two groups were no obvious adverse reactions. Conclusion: the characteristics of traditional Chinese Medicine treatment, Su God can have total efficiency of treatment were significantly improved, quickly relieve clinical symptoms in children with rotavirus, shorten the course, reduce the duration of fever, diarrhea, and related TCM clinical symptoms improved significantly, in addition, can effectively reduce the In the late stage of illness, children's loss of appetite, nausea and vomiting can provide a possibility for the recovery of gastrointestinal system and the establishment of immune system, and reduce the risk of other gastrointestinal diseases.

【學(xué)位授予單位】：廣州中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類(lèi)號(hào)】：R725.1

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