本文選題：兒童　切入點(diǎn)：抗NMDAR腦炎　出處：《福建醫(yī)科大學(xué)》2015年碩士論文

【摘要】：【目的】探討兒童抗NMDAR腦炎(Anti-NMDAR encephalitis,ANE)患者的臨床特點(diǎn),提高對(duì)該病的認(rèn)識(shí)�！痉椒ā繉�(duì)2012年9月至2015年3月福建省立醫(yī)院兒科3例臨床診斷為抗NMDAR腦炎患者進(jìn)行回顧性調(diào)查及隨訪研究,探討其臨床特點(diǎn)、治療及預(yù)后相關(guān)因素�！窘Y(jié)果】3例患者中,男性2例,女性1例(年齡5歲-9歲,平均年齡6歲)。臨床表現(xiàn)主要為抽搐(2例),頭痛(1例),精神異常(3例),語(yǔ)言障礙(1例),自主神經(jīng)癥狀(1例),睡眠障礙(1例),刻板動(dòng)作(1例)等;MRI提示雙側(cè)頂葉腦室三角區(qū)白質(zhì)區(qū)斑片狀異常信號(hào)(1例);腦電圖呈彌漫性慢波,其中1例出現(xiàn)銳波樣放電;腦脊液白細(xì)胞數(shù)升高(2例);腦脊液寡克隆蛋白檢測(cè)陽(yáng)性(3例);腦脊液抗NMDAR抗體陽(yáng)性(3例)。其中2例經(jīng)甲潑尼龍和免疫球蛋白治療痊愈,1例經(jīng)抗癲癇治療后好轉(zhuǎn)�！窘Y(jié)論】?jī)和筃MDAR腦炎的常見(jiàn)臨床表現(xiàn)為精神異常、抽搐、運(yùn)動(dòng)障礙、睡眠障礙等,腦脊液和(或)血漿抗NMDAR抗體檢測(cè)是診斷該病的特異性輔助檢查,免疫治療療效顯著,預(yù)后較好。
[Abstract]:[objective] to investigate the clinical characteristics of children with Anti-NMDAR encephalitis ANEA (Anti-NMDAR encephalitis).[methods] from September 2012 to March 2015, 3 pediatric patients diagnosed as anti-encephalitis in Fujian Provincial Hospital were retrospectively investigated and followed up, and their clinical characteristics were discussed.Treatment and prognostic factors. [results] among the 3 patients, 2 were male and 1 was female (age 5-9 years, mean age 6 years).The main clinical manifestations were convulsive syndrome (n = 2), headache (n = 1), mental disorder (n = 3), speech disorder (n = 1), autonomic nervous system (n = 1), sleep disorder (n = 1), white matter area in the trigonometry of parietal ventricle (n = 1).A case of abnormal signal in the pattern of plaque was found in 1 case, and the EEG showed diffuse slow wave, and the electroencephalogram (EEG) showed diffuse slow wave.Among them, 1 case had sharp wave discharge, 2 cases had increased white blood cell count in cerebrospinal fluid, 3 cases had positive oligoclonal protein detection in cerebrospinal fluid, 3 cases had anti NMDAR antibody positive in cerebrospinal fluid.The detection of anti NMDAR antibody in cerebrospinal fluid and / or plasma is a specific adjuvant examination for diagnosis of the disease.
【學(xué)位授予單位】：福建醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類號(hào)】：R742.1

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