本文選題：益生菌　切入點(diǎn)：早產(chǎn)兒　出處：《中國實(shí)用兒科雜志》2017年02期

【摘要】：新生兒壞死性小腸結(jié)腸炎(NEC)是新生兒期常見的嚴(yán)重胃腸道急癥,以往研究認(rèn)為,早產(chǎn)、感染、配方奶喂養(yǎng)、缺血缺氧是引發(fā)NEC的重要因素。近年來大量研究表明,腸道菌群失衡是引發(fā)NEC的重要和基礎(chǔ)原因,新生兒生后腸道獲取健康的共生菌,可以阻斷因腸道正常菌群缺失或異常的菌群定植過程,使未成熟腸道免于炎癥或損傷,這是降低NEC發(fā)生風(fēng)險(xiǎn)的關(guān)鍵因素。提供益生菌可維護(hù)腸道菌群平衡,使致病型微生態(tài)模式轉(zhuǎn)換至保護(hù)型健康的微生態(tài)模式,防御腸道的炎癥損害,預(yù)防NEC發(fā)生。此篇文章闡述了早產(chǎn)兒NEC與腸道菌群的關(guān)系,闡明了益生菌制劑防治NEC的作用機(jī)制、臨床療效和安全性。
[Abstract]:Neonatal necrotizing enterocolitis (NEC) is a common severe gastrointestinal emergency in neonatal stage. Previous studies have suggested that premature delivery infection formula feeding ischemia and hypoxia are important factors causing NEC.In recent years, a large number of studies have shown that the imbalance of intestinal flora is an important and basic cause of NEC. The healthy symbiotic bacteria obtained from the intestinal tract of newborn infants can block the process of colonization due to the absence or abnormality of normal intestinal flora.Keeping immature intestines free from inflammation or damage is a key factor in reducing the risk of NEC.The probiotics can maintain the balance of intestinal flora, change the pathogenic microecological model to the protective microecological model, protect the intestinal inflammatory damage and prevent the occurrence of NEC.This article describes the relationship between NEC and intestinal flora in premature infants, and illustrates the mechanism, clinical efficacy and safety of probiotics in preventing and treating NEC.
【作者單位】： 河北醫(yī)科大學(xué)第三醫(yī)院兒科;
【分類號(hào)】：R722.1

【參考文獻(xiàn)】

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