本文選題：淋巴細(xì)胞　切入點(diǎn)：細(xì)菌感染　出處：《中國(guó)全科醫(yī)學(xué)》2017年S2期

【摘要】：目的建立細(xì)菌合并病毒混合感染給予抗生素治療后處于恢復(fù)期的3個(gè)月~5歲患兒淋巴細(xì)胞比率的參考范圍,并初步探討其有關(guān)影響因素。方法收集高密市婦幼保健院2006年5月—2016年5月住院治療經(jīng)咽拭子細(xì)菌、病毒檢測(cè),確診為細(xì)菌合并病毒感染的上呼吸道感染的3個(gè)月~5歲的患兒1 000例,收集全部研究對(duì)象的臨床資料,應(yīng)用SPSS 17.0對(duì)檢驗(yàn)結(jié)果進(jìn)行統(tǒng)計(jì)分析。結(jié)果本研究共收集3個(gè)月~5歲患兒1 000例,均為細(xì)菌合并病毒感染,其中男596例,女404例。3個(gè)月~1歲組恢復(fù)期淋巴細(xì)胞比率與其他年齡組比較,差異有統(tǒng)計(jì)學(xué)意義(P0.05);其他年齡組恢復(fù)期淋巴細(xì)胞比率比較,差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。入院前淋巴細(xì)胞比率、中性粒細(xì)胞比率與恢復(fù)期淋巴細(xì)胞比率有相關(guān)性(P0.05)。是否應(yīng)用單磷酸阿糖腺苷、大環(huán)內(nèi)酯類藥物的患兒恢復(fù)期淋巴細(xì)胞比率比較,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。Logistic回歸分析顯示,應(yīng)用大環(huán)內(nèi)酯類藥物(OR=0.393,P=0.032)是促進(jìn)恢復(fù)期淋巴細(xì)胞比率降低的因素。根據(jù)是否應(yīng)用此類藥物分別確定其參考范圍,應(yīng)用大環(huán)內(nèi)酯類藥物患兒恢復(fù)期淋巴細(xì)胞比率為(57.38 12.14)%,即(45.244%~69.516%);未應(yīng)用大環(huán)內(nèi)酯類藥物患兒恢復(fù)期淋巴細(xì)胞比率為(63.74 10.09%)%,即(53.647%~73.833%)。結(jié)論是否應(yīng)用大環(huán)內(nèi)酯類對(duì)恢復(fù)期淋巴細(xì)胞比率有影響,參考范圍應(yīng)根據(jù)是否應(yīng)用大環(huán)內(nèi)酯類分別確立,便于指導(dǎo)臨床。
[Abstract]:Objective to establish the reference range of lymphocyte ratio of children aged 5 years old who were in convalescence stage after antibiotic treatment with mixed infection of bacteria and virus, and to explore the influencing factors.The clinical data of all the subjects were collected and the results were statistically analyzed by SPSS 17.0.The difference was statistically significant (P 0.05), but there was no significant difference in other age groups (P 0.05).The lymphocyte ratio, neutrophil ratio and lymphocyte ratio in convalescent stage were correlated with the ratio of lymphocyte before admission (P 0.05).The percentage of lymphocytes in children with adenosine arabinomonophosphate and macrolides in convalescent stage was significantly higher than that in children treated with adenosine arabinoate monophosphate and macrolides. Logistic regression analysis showed that,The application of macrolide 0.393Pu 0.032 was a factor to promote the decrease of lymphocyte ratio in convalescent stage.Conclusion the effect of macrolides on lymphocyte ratio in convalescent stage should be determined according to whether macrolides are used or not, so as to guide clinical practice.
【作者單位】： 濰坊醫(yī)學(xué)院;高密市婦幼保健院;濰坊市人民醫(yī)院;
【分類號(hào)】：R725.1

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