本文選題：抑郁癥　切入點(diǎn)：兒童　出處：《山東醫(yī)藥》2017年20期

【摘要】：目的探討氟西汀聯(lián)合多塞平治療兒童抑郁癥的療效及安全性。方法將100例抑郁癥兒童(8~14歲)隨機(jī)均分為觀察組和對(duì)照組,每組50例。兩組均給予多塞平治療,觀察組再給予氟西汀治療,療程均為6周。兩組分別于治療前及治療2、4、6周時(shí)進(jìn)行漢密爾頓抑郁量表(HAMD)及漢密爾頓焦慮量表(HAMA)、副反應(yīng)量表(TESS)評(píng)分,治療6周評(píng)價(jià)療效及不良反應(yīng)。結(jié)果兩組治療2、4、6周HAMD、HAMA評(píng)分均逐漸降低,觀察組降低幅度更大(P均0.05)。兩組治療2、4、6周時(shí)TESS評(píng)分比較差異均無(wú)統(tǒng)計(jì)學(xué)意義(P均0.05)。觀察組治療總有效率為92.00%,高于對(duì)照組的76.00%(P0.05)。觀察組治療期間不良反應(yīng)發(fā)生率為36.00%,對(duì)照組為26.00%,兩組比較P0.05;對(duì)照組嗜睡發(fā)生率高于觀察組,觀察組失眠和皮疹發(fā)生率高于對(duì)照組(P均0.05)。結(jié)論多賽平聯(lián)合氟西汀可提高抑郁癥兒童的治療效果,但聯(lián)合用藥可能增加患兒皮疹、失眠的發(fā)生率。
[Abstract]:Objective to investigate the efficacy and safety of fluoxetine combined with doxepin in the treatment of depression in children. Methods 100 children with depression aged 814 years were randomly divided into observation group and control group with 50 cases in each group. The observation group was treated with fluoxetine for 6 weeks. The two groups were evaluated with Hamilton Depression scale (Hamd), Hamilton anxiety scale (Hamilton anxiety scale) and side effects scale (TESS) before and after 2 weeks of treatment. Results the score of HAMD-Hama in the two groups decreased gradually at 6 weeks after treatment. There was no significant difference in TESS scores between the two groups at 6 weeks after treatment. The total effective rate of treatment in the observation group was 92.00, which was higher than that in the control group (76.00 and P 0.05). The incidence of adverse reactions in the observation group was 36.00. The incidence of somnolence in the control group was higher than that in the observation group. Conclusion doxepin combined with fluoxetine can improve the therapeutic effect of depression in children with depression, but combined therapy may increase the incidence of rash and insomnia in children.
【作者單位】： 廣州市婦女兒童醫(yī)療中心;
【分類(lèi)號(hào)】：R749.4

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