本文選題：維生素E　切入點：早產(chǎn)兒貧血　出處：《山東大學(xué)》2012年碩士論文　論文類型：學(xué)位論文

【摘要】：目的：探討不同劑量VitE在預(yù)防早產(chǎn)兒貧血中的臨床療效。 方法：選擇我院NICU病房2009年10月至2011年10月收治的早產(chǎn)兒60例,按入院先后順序隨機(jī)分組為A、B、C3組。A組為對照組：20例,常規(guī)早產(chǎn)兒奶粉喂養(yǎng)及部分靜脈營養(yǎng)支持治療。在上述對照治療的基礎(chǔ)上,入院后第3天起給予口服不同劑量的VitE為治療組,連用4周。B組為小劑量組：20例,VitE5mg/kg.qd；C組為大劑量組：20例,VitE30mg/kg.qd。觀察治療過程中各組紅細(xì)胞(RBC)、血紅蛋白(Hb)、紅細(xì)胞壓積(Hct)、網(wǎng)織紅細(xì)胞(Ret)及其治療前后血清Vi tE濃度的變化情況。 結(jié)果：B、C組患者治療后紅細(xì)胞(RBC)、血紅蛋白(Hb)、紅細(xì)胞壓積(Hct)、網(wǎng)織紅細(xì)胞(Ret)均有改善,各項指標(biāo)改善程度均優(yōu)于A組(P0.05),R與C組各項指標(biāo)改善程度對比差別無統(tǒng)計學(xué)意義(P0.05)。B、C組患者治療后血清VitE的濃度均明顯升高,且差別有統(tǒng)計學(xué)意義(P0.05),A組患者血清中VitE濃度明顯下降。 結(jié)論：1、早產(chǎn)兒生后3天均應(yīng)開始補(bǔ)充VitE,推薦劑量Vi tE5mg/kg.d,為最佳用藥劑量。2、應(yīng)用以上VitE劑量,可降低早產(chǎn)兒貧血的發(fā)生,減少輸血頻次。3、以上劑量血清中VitE的濃度是安全的,符合生理需要量,臨床未發(fā)現(xiàn)不良反應(yīng)。
[Abstract]:Objective: to investigate the clinical effect of different doses of VitE on prevention of anemia in premature infants. Methods: 60 premature infants were selected from October 2009 to October 2011 in NICU ward of our hospital. 20 cases of control group were randomly divided into group A (group A) and group A (n = 20). Routine premature infants were fed with milk powder and partial intravenous nutrition support. On the basis of the above control treatment, oral VitE with different doses was given to the treatment group from the third day after admission. After 4 weeks of treatment, 20 patients in group B were treated with small dose of Vitamin E 5 mg / kg / kg 路qdN C, and 20 cases in Group C were treated with Vitamin E 30 mg / kg 路qd.The changes of serum VitE concentrations in each group were observed during the course of treatment, such as RBC, HBC, HCT, reticulocyte (Ret) and before and after treatment. Results after treatment, RBC, HB, HCT, Ret of reticulocyte in group C were improved. The improvement degree of each index was better than that of group A (P 0.05) and group C (P 0.05). There was no significant difference in the improvement degree between group A and group C. The serum VitE levels of patients in group P0.05 were significantly higher than those in group C after treatment. There was a significant difference in serum VitE concentration in P0.05A group. ConclusionVit should be replenished 3 days after birth in premature infants. The recommended dose of Vi tE 5 mg / kg 路d was the best dose of Vi tE 5 mg / kg 路d. The above dose of VitE could reduce the incidence of anemia and reduce the frequency of blood transfusion. The concentration of VitE in serum at the above dose was safe. In accordance with physiological requirements, no adverse reactions were found clinically.
【學(xué)位授予單位】：山東大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2012
【分類號】：R722.6

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本文編號：1620739