本文選題：巨細胞病毒　切入點：膽道畸形　出處：《重慶醫(yī)科大學》2012年碩士論文　論文類型：學位論文

【摘要】：目的： 探討嬰兒膽道畸形（膽道閉鎖、膽道狹窄）與巨細胞病毒感染的關(guān)系，了解膽道畸形合并巨細胞病毒感染在臨床表現(xiàn)、肝功能、病檢結(jié)果上的特點。 方法： 回顧性分析我院收治，經(jīng)手術(shù)造影證實的48例膽道畸形患兒臨床資料，根據(jù)巨細胞病毒感染與否將病人分組，比較兩組患兒在肝功能，肝臟活檢病檢結(jié)果上的異同。 結(jié)果： 1.48例膽道畸形患兒中，合并巨細胞病毒感染22例，占45.8%。37例膽道閉鎖患兒中，感染組17例與非感染組20例的γ-GT、ALP及小膽管增生程度有顯著性差異(P0.05)；11例膽道狹窄患兒中，感染組5例與非感染組6例在肝功能及病檢結(jié)果上無顯著性差異。 2.37例膽道閉鎖患兒與11例膽道狹窄患兒相比，在巨細胞病毒感染率上無顯著性差異，在γ-GT及小膽管增生程度上存在顯著性差異(P0.05)；48例膽道畸形患兒中，，小膽管輕度增生組與重度增生組γ-GT、TBA水平存在顯著性差異(P0.05)。 結(jié)論： 1.巨細胞病毒感染可引起膽管上皮細胞受損，引起或加重膽道閉鎖患兒的膽管損傷，加重匯管區(qū)小膽管增生程度。 2.小膽管增生程度與膽汁淤積程度和膽管上皮細胞受損的嚴重程度存在相關(guān)性。
[Abstract]:Objective:. To investigate the relationship between biliary malformation (biliary atresia, biliary stricture) and cytomegalovirus infection in infants. Methods:. The clinical data of 48 children with biliary tract malformation confirmed by surgical angiography were analyzed retrospectively. According to cytomegalovirus infection or not, the differences and similarities of liver function and liver biopsy were compared between the two groups. Results:. 1.Among 48 children with biliary malformation, 22 cases were complicated with cytomegalovirus infection, accounting for 45.8.37 cases of biliary atresia. There were significant differences in 緯 -GThelP and hyperplasia of small bile duct in 17 cases of infection group and 20 cases of non-infection group in 11 cases of biliary stricture. There was no significant difference in liver function and pathological examination results between the infection group (5 cases) and the non-infected group (6 cases). 2.There was no significant difference in cytomegalovirus infection rate between 37 children with biliary atresia and 11 children with biliary stricture, but there was significant difference in 緯 -GT and the degree of hyperplasia of small bile duct in 48 patients with biliary tract malformation. There was significant difference in TBA level between mild hyperplasia group and severe hyperplasia group (P 0.05). Conclusion:. 1. Cytomegalovirus infection can damage bile duct epithelial cells, cause or aggravate bile duct injury in children with biliary atresia, and aggravate the degree of hyperplasia of small bile duct in catchment area. 2. The degree of small bile duct hyperplasia was correlated with the degree of cholestasis and the severity of bile duct epithelial cell damage.
【學位授予單位】：重慶醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2012
【分類號】：R726.5

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