本文選題：原發(fā)性腎病綜合征　切入點(diǎn)：高尿酸血癥　出處：《青島大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:分析原發(fā)性腎病綜合征患兒疾病活動(dòng)期血清尿酸水平變化特點(diǎn)及其相關(guān)影響因素,為原發(fā)性腎病綜合征患兒的飲食指導(dǎo)提供依據(jù)。方法:選擇111例住院治療的原發(fā)性腎病綜合征患兒為研究對象,同時(shí)選擇139名健康體檢或因隱睪、鞘膜積液和腹股溝疝等待手術(shù)的兒童作為對照組,兩組間年齡和性別構(gòu)成相似(P0.05)。采用回顧性分析方法對原發(fā)性腎病綜合征患兒的臨床資料進(jìn)行統(tǒng)計(jì)處理,分析原發(fā)性腎病綜合征患兒血清尿酸水平變化特點(diǎn)、不同臨床分型腎病綜合征患兒間血清尿酸水平有無差異及腎病綜合征患兒血清尿酸水平與其他血清生化指標(biāo)間的相關(guān)性。結(jié)果:原發(fā)性腎病綜合征患兒組疾病活動(dòng)期血清尿酸水平為(290.19±97.19)mmol/L,顯著高于對照組【(223.77±61.70)mmol/L】差異有極顯著性統(tǒng)計(jì)學(xué)意義(t=6.261,P0.01);單純性腎病綜合征組和腎炎性腎病綜合征組疾病活動(dòng)期血清尿酸水平分別為(281.20±93.30)mmol/L、(314.03±99.03)mmol/L,兩組間差異無顯著性統(tǒng)計(jì)學(xué)意義(t=1.506,P0.05);激素敏感性腎病綜合征組和激素耐藥性腎病綜合征組疾病活動(dòng)期血清尿酸水平分別為(289.16±96.05)mmol/L、(297.26±108.34)mmol/L,兩組間差異無顯著性統(tǒng)計(jì)學(xué)意義(t=-0.296,P0.05)。Pearson單因素相關(guān)分析顯示,原發(fā)性腎病綜合征患兒疾病活動(dòng)期血清尿酸水平與血清尿素氮、肌酐呈中度正相關(guān)(r=0.491、0.396,P均0.01),與血清鎂、血清磷、總膽固醇水平呈低度正相關(guān)(r分別為0.293、0.188、0.192,P均0.05),而與血清鈣、血清鈉、白蛋白低度負(fù)相關(guān)(r分別為-0.286、-0.345、-0.208,P分別0.01、0.01、0.05),而與血清甘油三脂、葡萄糖水平間無相關(guān)性(r=0.014、0.091,P均0.05)。結(jié)論:原發(fā)性腎病綜合征患兒疾病活動(dòng)期血清尿酸水平明顯升高,而疾病臨床分型間無明顯差異;原發(fā)性腎病綜合征患兒尿酸代謝異�？赡芘c腎功能狀態(tài)、脂質(zhì)及電解質(zhì)代謝紊亂等有關(guān);原發(fā)性腎病綜合征患兒飲食指導(dǎo)內(nèi)容中應(yīng)包括低嘌呤攝入。
[Abstract]:Objective: to analyze the changes of serum uric acid in children with primary nephrotic syndrome and its related factors. Methods: 111 hospitalized children with primary nephrotic syndrome were selected as subjects, and 139 healthy children were selected for physical examination or cryptorchidism. Children with hydrocele and inguinal hernia were used as control group. The age and sex composition of the two groups were similar (P 0.05). The clinical data of children with primary nephrotic syndrome were analyzed retrospectively. To analyze the changes of serum uric acid level in children with primary nephrotic syndrome, The serum uric acid level in children with nephrotic syndrome was different and the correlation between serum uric acid level and other serum biochemical indexes in children with nephrotic syndrome. Results: the disease activity of children with primary nephrotic syndrome was significant. The serum uric acid level in the active phase was 290.19 鹵97.19 mmol / L, which was significantly higher than that in the control group [223.77 鹵61.70 渭 mol / L], and the serum uric acid levels in the patients with simple nephrotic syndrome and nephritis nephrotic syndrome were 281.20 鹵93.30 mmol / L and 314.03 鹵99.03 mmol / L, respectively, and the levels of serum uric acid in the patients with simple nephrotic syndrome and nephritis nephrotic syndrome were 314.03 鹵99.03 mmol / L, respectively, and the levels of serum uric acid in the patients with simple nephrotic syndrome and those with nephritic nephrotic syndrome were 314.03 鹵99.03 mmol / L and 314.03 鹵99.03 mmol / L, respectively. The serum uric acid levels in the steroid-sensitive nephrotic syndrome group and the steroid-resistant nephrotic syndrome group were 289.16 鹵96.05 mmol / L 297.26 鹵108.34 mmol / L, respectively. There was no significant difference between the two groups in terms of correlation between the two groups. In children with primary nephrotic syndrome, serum uric acid level was positively correlated with serum urea nitrogen, creatinine was positively correlated with serum urea nitrogen, creatinine was 0.491n 0.396U P, and low correlation with serum magnesium, serum phosphorus and total cholesterol was 0.2930.1880.192P, respectively, but with serum calcium, serum sodium. The low negative correlation between albumin and serum triglyceride and glucose levels were -0.286 and -0.345- 0.208, respectively, and there was no correlation with serum triglyceride and glucose levels. Conclusion: serum uric acid level in children with primary nephrotic syndrome was significantly increased in active stage, and was not correlated with serum triglyceride and glucose levels in children with primary nephrotic syndrome (P < 0.05), but there was no significant correlation between serum uric acid level and serum triglyceride and glucose levels in children with primary nephrotic syndrome. The abnormal uric acid metabolism in children with primary nephrotic syndrome may be related to renal function disorder of lipid and electrolyte. Low purine intake should be included in dietary guidance for children with primary nephrotic syndrome.
【學(xué)位授予單位】：青島大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R726.9

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 劉華英;顧丹陽;邵加慶;;高尿酸血癥與內(nèi)皮功能障礙[J];國際內(nèi)分泌代謝雜志;2016年06期

2 王晶晶;毛建華;;兒童高尿酸血癥及相關(guān)腎損害的發(fā)生機(jī)制及臨床意義[J];中華兒科雜志;2016年09期

3 宣丹旦;薛愉;鄒和建;;痛風(fēng)和高尿酸血癥患者的飲食控制[J];上海醫(yī)藥;2015年11期

4 王莉;徐柳青;施映楓;熊重祥;鮑文芳;嚴(yán)海東;劉娜;莊守綱;;高尿酸血癥腎損害動(dòng)物模型建立及發(fā)生機(jī)制研究[J];中華腎臟病雜志;2015年03期

5 肖慧捷;李倩;王芳;姚勇;鐘旭輝;;兒童原發(fā)性腎病綜合征合并高尿酸血癥臨床分析[J];中華兒科雜志;2014年11期

6 肖慧捷;李倩;;高尿酸血癥與腎臟疾病[J];中華實(shí)用兒科臨床雜志;2014年17期

7 劉倩;劉維英;朱慶齡;葉新華;原新慧;陳虹;;學(xué)齡期肥胖兒童血尿酸水平及相關(guān)因素分析[J];臨床兒科雜志;2013年09期

8 范博涵;王瑋;李寒;;腎移植術(shù)后高尿酸血癥的研究進(jìn)展[J];國際移植與血液凈化雜志;2013年04期

9 羅曉媛;吳新榮;;吡嗪酰胺致高尿酸血癥[J];實(shí)用藥物與臨床;2013年03期

10 Lucia Pacifico;Valerio Nobili;Caterina Anania;Paola Verdecchia;Claudio Chiesa;;Pediatric nonalcoholic fatty liver disease,metabolic syndrome and cardiovascular risk[J];World Journal of Gastroenterology;2011年26期

，

本文編號(hào)：1594732