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  本文選題：桑沙顆粒　切入點：小兒急性氣管-支氣管炎　出處：《云南中醫(yī)學(xué)院》2017年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:對桑沙顆粒治療小兒急性氣管-支氣管炎風(fēng)燥傷肺型的臨床療效進行客觀評價,并初步評估其安全性,為該藥的臨床應(yīng)用提供依據(jù)。方法:(1)臨床研究:將符合標(biāo)準(zhǔn)的患兒分為觀察組(桑沙顆粒組)和對照組(桑菊感冒顆粒組),每組最終有效病例各30例,6天為一療程,治療1個療程,觀察記錄并比較兩組治療前后的證候量化評分,對桑沙顆粒的臨床療效進行科學(xué)客觀地評估。(2)急性毒性實驗:在預(yù)實驗測不出半數(shù)致死量(LD50)的情況下,以最大給藥量法設(shè)計正式實驗初步評估桑沙顆粒的安全性。結(jié)果:(1)臨床研究:桑沙顆粒能消除或緩解小兒急性氣管-支氣管炎風(fēng)燥傷肺型所表現(xiàn)的咳嗽、咯痰、咽癢癥狀,且能明顯的改善患兒咽部充血、扁桃體腫大、飲食減少等情況。(1)兩組治療均能有效消除或減輕小兒急性氣管-支氣管炎風(fēng)燥傷肺型所引起的多種癥狀、體征(P0.05);(2)觀察組和對照組治療小兒急性氣管-支氣管炎風(fēng)燥傷肺型的總有效率分別為90%、86.7%,差別無統(tǒng)計學(xué)意義(P0.05);(3)觀察組在改善小兒急性氣管-支氣管炎風(fēng)燥傷肺型主要證候方面優(yōu)于對照組,差別有統(tǒng)計學(xué)意義(P0.05),而在改善小兒急性氣管-支氣管炎風(fēng)燥傷肺型總體證候、次要證候方面,兩組療效相當(dāng),差別無統(tǒng)計學(xué)意義(P0.05);(4)兩組在改善小兒急性氣管-支氣管炎風(fēng)燥傷肺型所引起的咽痛、肺部體征、鼻塞、流涕、舌象、大便干結(jié)方面療效相當(dāng),差別無統(tǒng)計學(xué)意義(P0.05);(5)觀察組在改善小兒急性氣管-支氣管炎風(fēng)燥傷肺型所引起的咳嗽、咯痰、咽癢、咽部充血、扁桃體腫大、飲食減少方面療效優(yōu)于對照組,差別有統(tǒng)計學(xué)意義(P0.05);(6)兩組在改善患兒血細胞分析異常方面療效相當(dāng),差別無統(tǒng)計學(xué)意義(P0.05);(7)兩組患兒治療過程中均未發(fā)生不良反應(yīng)。(2)急性毒性實驗:實驗小鼠均未出現(xiàn)死亡,給藥后一般情況好,實驗完成后對其進行解剖,肉眼大致觀察其主要臟器均未見明顯異常。根據(jù)實驗藥物(桑沙顆粒)的小鼠1日最大給藥量法進行估算,等同于臨床上成人1日臨床用量的120.08倍,實驗中均未見小鼠經(jīng)口單次給藥毒性反應(yīng)。結(jié)論:通過對桑沙顆粒的臨床研究及急性毒性實驗,表明桑沙顆粒是治療小兒急性氣管-支氣管炎風(fēng)燥傷肺型的有效方,并且安全,值得臨床使用和推廣。
[Abstract]:Objective: to evaluate the clinical efficacy and safety of Sansha granule in the treatment of acute tracheobronchial wind dryness in children. Methods: the children who met the standard were divided into observation group (Sansha granule group) and control group (mulberry chrysanthemum cold granule group). Each group had 30 effective cases for 6 days as a course of treatment. After one course of treatment, the quantitative syndromes scores before and after treatment were observed and compared between the two groups. The clinical efficacy of Sansha granules was evaluated scientifically and objectively. To evaluate the safety of Sangsha granules by the method of maximum dose. Results: Sangsha granule can eliminate or relieve the symptoms of cough, sputum and pharyngoitch in children with acute trachea bronchitis wind dryness injury. And can obviously improve the pharynx hyperemia, tonsillar enlargement, diet decrease and so on.) both groups can effectively eliminate or alleviate many symptoms caused by acute trachea bronchitis wind dryness injury lung type. The total effective rate of treatment of acute trachea bronchitis wind dryness injury in children in observation group and control group was 900.86. 7, respectively. There was no significant difference between observation group and control group in improving the lung type of acute tracheo-bronchitis wind dryness injury. Syndromes were superior to those in the control group. The difference was statistically significant (P 0.05), but in improving the overall syndrome and secondary syndromes of acute trachea bronchitis wind dryness injury in children, the two groups had the same curative effect. There was no significant difference between the two groups (P 0.05). The two groups had the same effect in improving pharynx pain, lung signs, nasal congestion, runny nose, tongue picture and stool dry knot caused by acute trachea bronchitis wind dryness injury in children. The effect of observation group on improving cough, sputum, pharynx itch, pharynx congestion, tonsil enlargement and diet reduction caused by acute trachea bronchitis wind dryness injury in children was better than that in the control group. The difference was statistically significant (P 0.05) the two groups had the same effect in improving the abnormal blood cell analysis in children, but there was no significant difference in the difference between the two groups (P 0. 05) there was no adverse reaction. 2) the acute toxicity test: no death was found in all the experimental mice, but there was no significant difference between the two groups in the course of treatment (P 0. 05 and P 0. 05, P < 0. 05, P < 0. 05). After administration, the mice were dissected and their main organs were observed by naked eye without obvious abnormality. According to the method of maximum dose of the experimental drug (Sangsha granules) on 1st, It is equal to 120.08 times of the clinical dosage of adult in 1st. No single oral toxicity reaction was found in mice. Conclusion: the clinical study and acute toxicity test of Sangsha granules were carried out. The results indicate that Sansha granule is an effective prescription for the treatment of acute trachea-bronchitis wind dryness in children, and it is safe and worthy of clinical use and popularization.
【學(xué)位授予單位】：云南中醫(yī)學(xué)院
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R272

【參考文獻】

相關(guān)期刊論文 前10條

1 黃荊南;;利巴韋林在兒童患者中的使用情況分析[J];河南醫(yī)學(xué)研究;2015年09期

2 陳斌;魏丹霞;顧力華;陸家龍;;陸家龍論治昆明地區(qū)燥咳經(jīng)驗[J];廣州中醫(yī)藥大學(xué)學(xué)報;2015年01期

3 梁義國;;氨溴特羅口服液用于小兒支氣管炎臨床治療的效果分析[J];吉林醫(yī)學(xué);2014年35期

4 劉足桂;梁生林;;蘆根水煎劑對小鼠的抗炎作用初探[J];中國醫(yī)藥指南;2014年34期

5 黃志英;程寶金;林紅;張小玉;萬瑜;;3483例兒童急性呼吸道感染病毒病原學(xué)分析[J];兒科藥學(xué)雜志;2014年08期

6 劉理琴;;清燥救肺湯加減治療肺燥咳嗽的臨床觀察[J];光明中醫(yī);2014年07期

7 許婭嬋;;中藥灌腸對小兒咳嗽的療效及護理觀察[J];中國地方病防治雜志;2014年S1期

8 蒙新華;;應(yīng)用抗生素序貫療法治療兒童急性呼吸道感染的療效觀察[J];當(dāng)代醫(yī)藥論叢;2014年07期

9 郭靜則;;兒科抗生素合理應(yīng)用的臨床價值分析[J];中國醫(yī)藥指南;2014年01期

10 王至婉;趙棟梁;張?zhí)?李建生;李素云;余學(xué)慶;杜保榮;;急性氣管-支氣管炎證候分布規(guī)律的臨床調(diào)查[J];時珍國醫(yī)國藥;2013年09期

相關(guān)碩士學(xué)位論文 前1條

1 甘露;大鼠pEGFP-N1-BKβ_1真核表達載體的構(gòu)建及苦杏仁苷對支氣管平滑肌細胞增殖的研究[D];華中科技大學(xué);2007年

，

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