發(fā)布時(shí)間：2018-03-06 04:38

  本文選題：嗎啡　切入點(diǎn)：手足口病　出處：《廣東醫(yī)學(xué)》2017年18期 　論文類型：期刊論文

【摘要】：目的觀察嗎啡聯(lián)合炎琥寧注射液對(duì)手足口病合并中樞神經(jīng)損傷患兒的臨床療效。方法收集臨床確證的手足口病合并中樞神經(jīng)損傷患兒92例,隨機(jī)分為對(duì)照組(n=46)和觀察組(n=46),對(duì)照組除了常規(guī)的退熱、補(bǔ)液及補(bǔ)充維生素C之外給予炎琥寧注射液10 mg/(kg·d)加入100 m L 50 g/L葡萄糖溶液中進(jìn)行靜脈滴注;觀察組在此基礎(chǔ)上將鹽酸嗎啡(0.05 mg/kg)用5 m L生理鹽水稀釋后靜脈推注,另將用50 g/L葡萄糖溶液稀釋的鹽酸嗎啡以20μg/(kg·h)的速度勻速輸注,1次/d,7 d為1個(gè)療程,治療結(jié)束后,分別對(duì)兩組患兒的超敏C反應(yīng)蛋白(hs-CRP)、腦源性神經(jīng)營(yíng)養(yǎng)因子(brain derived neurotrophic factor,BDNF)、神經(jīng)元特異性烯醇化酶(2-phospho-D-glycerate hydrolase,NSE)、S-100β蛋白、內(nèi)皮素-1(endothelin,ET-1)及神經(jīng)肽Y(neuropeptide Y,NPY)的水平進(jìn)行檢測(cè),統(tǒng)計(jì)分析檢測(cè)結(jié)果。結(jié)果觀察組患兒總顯效率及痊愈率均高于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。與對(duì)照組治療后比較,觀察組治療后NSE、S-100β、BDNF、ET-1、NPY及hs-CRP顯著降低(P0.05)。結(jié)論嗎啡有利于手足口病合并神經(jīng)損傷的恢復(fù)和改善。
[Abstract]:Objective to observe the clinical effect of morphine combined with Yanhuning injection on children with HFMD complicated with central nervous system injury. The control group was randomly divided into two groups: control group (n = 46) and observation group (n = 46). In addition to routine antipyretic, rehydration and vitamin C supplementation, the control group was given 10 mg/(kg 路d of Yanhuning injection (10 mg/(kg 路d) plus 100ml 50 g / L glucose solution for intravenous drip. On this basis, morphine hydrochloride 0.05 mg 路kg ~ (-1) was diluted with 5 mL normal saline and injected intravenously with 50 g / L dextrose solution of morphine hydrochloride at a speed of 20 渭 g / kg 路h) for 7 days as a course of treatment. The levels of hypersensitive C-reactive protein (hs-CRP), brain-derived neurotrophic factor (brain-derived neurotrophic factor) derived neurotrophic factor-BDNFN, neuron-specific enolase 2-phospho-D-glycerate hydrolase S-100 尾, endothelin 1 endothelin1 (et 1) and neuropeptide Y neuropeptide (YN) were measured in the two groups. Results the total effective rate and cure rate in the observation group were higher than those in the control group, and the difference was statistically significant (P 0.05). In the observation group, NSES-100 尾 -BDNFT-1NPY and hs-CRP decreased significantly (P 0.05). Conclusion morphine is beneficial to the recovery and improvement of hand, foot and mouth disease with nerve injury.
【作者單位】： 許昌市第二人民醫(yī)院兒科;
【分類號(hào)】：R725.1

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本文編號(hào)：1573389