本文關(guān)鍵詞： 資生丸 膏方 兒童哮喘 肺脾氣虛 臨床研究　出處：《黑龍江中醫(yī)藥大學(xué)》2016年碩士論文　論文類型：學(xué)位論文

【摘要】：目的：觀察加減資生丸膏劑治療兒童支氣管哮喘(肺脾氣虛證)的臨床療效。方法：將實(shí)際符合兒童哮喘肺脾氣虛證的69例患兒,按隨機(jī)數(shù)字表法分為加減資生丸膏劑治療組和孟魯司特鈉片對(duì)照組,其中膏劑治療組為35例,西藥常規(guī)對(duì)照組34例,兩組均為5-14歲哮喘患兒。療程3個(gè)月,隨訪3個(gè)月。治療1個(gè)月后對(duì)比兩組治療前后臨床總體療效、中醫(yī)癥狀積分、肺功能中的小氣道功能恢復(fù)情況、大氣道PEF和FEV1對(duì)比治療前后改善情況、哮喘患兒發(fā)作次數(shù)及生活質(zhì)量狀況。療程結(jié)束后,隨訪3個(gè)月,觀測(cè)兩組患兒復(fù)發(fā)情況以及安全性監(jiān)測(cè)情況。此觀察研究應(yīng)用SPSS19.0或SAS 8.1統(tǒng)計(jì)學(xué)軟件進(jìn)行數(shù)據(jù)分析。結(jié)果：1.臨床總體療效情況。治療組治療后臨床痊愈9例(25.71%),顯效17例(48.57%),有效8例(22.86%),無效1例(2.86%)；對(duì)照組治療后臨床痊愈5例(14.71%)顯效9例(26.47%)有效15例(44.12%)無效5例(14.71%),且愈顯率治療組74.30%,對(duì)照組41.20%,膏劑治療組明顯優(yōu)于西藥常規(guī)對(duì)照組(P0.01)；而兩組總有效率經(jīng)比較,差異無統(tǒng)計(jì)學(xué)意義(P0.05)；2.中醫(yī)單項(xiàng)證候積分情況。治療組大便溏薄、面白少華、神疲、倦怠、形體消瘦、納差、氣短等證候積分情況,治療組優(yōu)于對(duì)照組(P0.05),并兩組治療后明顯優(yōu)于治療前(P0.05),具有統(tǒng)計(jì)學(xué)意義；3.肺功能情況。小氣道功能指標(biāo)FEF25%、FEF 50%、FEF75%、MMEF75/25%治療后均有優(yōu)于治療前(P0.05),并治療組優(yōu)于對(duì)照組(P0.05),具有統(tǒng)計(jì)學(xué)意義,而PEF及FEV1在治療前后,無顯著差異(P0.05)；4.哮喘患兒發(fā)作次數(shù)情況。治療組由哮喘患兒發(fā)作(3.54+1.27)次下降至(0.51±0.51)次,而對(duì)照組由(3.76±1.33)次下降至(1.38±0.60)次,經(jīng)統(tǒng)計(jì)學(xué)比較,治療組優(yōu)于對(duì)照組(P0.01),治療后優(yōu)于治療前(P0.01),差異具有統(tǒng)計(jì)學(xué)意義；5.哮喘患兒生活質(zhì)量情況。治療組哮喘患兒生活質(zhì)量由(2.00±0.41)提高到(3.45±0.39),而對(duì)照組(1.99±0.51)提高到(2.67±0.41),治療組優(yōu)于對(duì)照組(P0.01),治療后明顯優(yōu)于治療前(P0.01),差異具有統(tǒng)計(jì)學(xué)意義。6.兩組哮喘患兒復(fù)發(fā)情況。療程結(jié)束后,進(jìn)行隨訪3個(gè)月,分別從治療組和對(duì)照組臨床痊愈及顯效的患兒中隨機(jī)抽取數(shù)例哮喘患兒,治療組18例,復(fù)發(fā)3例,復(fù)發(fā)率16.67%；對(duì)照組11例,復(fù)發(fā)8例,復(fù)發(fā)率72.73%。兩組復(fù)發(fā)率比較,治療組明顯優(yōu)于對(duì)照組,差異具有統(tǒng)計(jì)學(xué)意義(P0.01)。7.兩組安全性情況。兩組各項(xiàng)指標(biāo)檢測(cè)未見明顯異常。并治療組和對(duì)照組進(jìn)行不良反應(yīng)統(tǒng)計(jì)時(shí),無顯著性差異(P0.05)。結(jié)論：1.加減資生丸膏劑治療兒童哮喘愈顯率74.30%明顯優(yōu)于對(duì)照組41.20%：2.加減資生丸膏劑對(duì)兒童哮喘肺脾氣虛證中醫(yī)單項(xiàng)證候改善情況明顯優(yōu)于對(duì)照組；3.加減資生丸膏劑改善小氣道功能明顯優(yōu)于對(duì)照組,但改善大氣道功能,如PEF、FEV1,無顯著差異；4.加減資生丸膏劑減少哮喘患兒發(fā)作次數(shù)明顯優(yōu)于對(duì)照組；5.加減資生丸膏劑改善哮喘患兒生活質(zhì)量明顯優(yōu)于對(duì)照組；6.加減資生丸膏劑控制哮喘患兒復(fù)發(fā)情況明顯優(yōu)于對(duì)照組；7.加減資生丸膏劑依從性較好,治療組與對(duì)照組比較不良反應(yīng),無顯著性差異。
[Abstract]:Objective: To observe the treatment of children with bronchial asthma reduction pills paste (lung and spleen deficiency syndrome) clinical curative effect. Methods: 69 cases of the children with asthma pulmonary syndrome, were randomly divided into treatment group and reduction pills paste and Montelukast Sodium Tablets group, the ointment for treatment of 35 cases in the group of Western medicine the conventional control group of 34 cases, two groups of 5-14 year old children with asthma. After 3 months of treatment, follow-up of 3 months. After 1 months of treatment between the two groups before and after treatment of clinical total curative effect, TCM symptom score, lung function in small airway function recovery, PEF and FEV1 before and after the airway compared treatment to improve the situation. The number of asthma attacks in children and the quality of life. After the end of treatment, after 3 months of follow-up, observation of two groups of children with recurrent and security monitoring. The observation and Study on the application of SPSS19.0 or SAS 8.1 statistical software for data analysis. 鏋滐細(xì)1.涓村簥鎬諱綋鐤楁晥鎯呭喌.娌葷枟緇勬不鐤楀悗涓村簥鐥婃剤9渚，

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