本文關(guān)鍵詞： 腸道微生物 腸道益生菌群 輪狀病毒 腸黏膜屏障 微生態(tài) 輕度胃腸炎伴良性嬰幼兒驚厥 腸炎　出處：《山東醫(yī)藥》2017年43期 　論文類型：期刊論文

【摘要】：目的探討患兒腸道內(nèi)微生物的變化與輕度胃腸炎伴良性嬰幼兒驚厥(BICE)之間的關(guān)系。方法選擇同期收治的BICE患兒50例(A組)、急性輕度胃腸炎患兒50例(B組)以及同期進(jìn)行體檢的健康兒童50例(C組),對三組的腸道內(nèi)微生物進(jìn)行檢測,并對其部分腸黏膜屏障指標(biāo)進(jìn)行觀察。結(jié)果 A組有24例糞便中檢出輪狀病毒(陽性率為48.00%),B組有10例糞便中檢出輪狀病毒(陽性率為20.00%),C組有1例糞便中檢出輪狀病毒(陽性率為2.00%);組間兩兩相比,P均0.05。A組糞便中大腸桿菌、腸球菌、乳酸桿菌、雙歧桿菌的數(shù)量分別為(7.65±2.24)×105、(6.13±2.32)×105、(4.83±1.62)×105、(5.02±1.46)×105CFU/g,B組分別為(8.79±2.31)×105、(7.45±2.28)×105、(6.12±2.47)×105、(5.81±1.86)×105CFU/g,C組分別為(9.87±1.68)×105、(9.12±2.20)×105、(8.35±2.12×105)、(6.82±1.20)×105CFU/g;組間兩兩相比,P均0.05。A組血清二胺氧化酶(DAO)、一氧化氮(NO)、D-乳酸水平分別為(9.84±4.17)U/L、(0.92±0.39)mmol/L、(156.78±48.25)μmol/L,B組分別為(7.49±2.73)U/L、(0.73±0.25)mmol/L、(102.45±40.45)μmol/L,C組分別為(6.35±1.61)U/L、(0.62±0.21)mmol/L、(86.36±30.12)μmol/L,血清DAO、NO、D-乳酸水平組間兩兩相比,P均0.05。結(jié)論 BICE患兒腸道內(nèi)輪狀病毒陽性率增高、各類益生菌群數(shù)量降低及腸黏膜屏障能力降低,以上原因可能與BICE的發(fā)病有關(guān),但致病機(jī)制尚不明確。
[Abstract]:Objective to investigate the relationship between the changes of intestinal microorganism in children with mild gastroenteritis and benign infantile convulsion (BICE). Methods 50 patients with BICE and 50 patients with acute mild gastroenteritis were treated in the same period. A total of 50 healthy children in group C were examined for intestinal microbes in three groups. Results rotavirus was detected in 24 cases of feces in group A (positive rate was 48.00%) and rotavirus was detected in 10 cases in group B (positive rate was 20.00%) in 1 case of feces in group C (positive rate was 20.00%). The positive rate of the virus was 2.00%, and the fecal Escherichia coli in the two groups was 0.05.A, the positive rate was 2.00%, and the positive rate was 2.00%. Enterococcus, Lactobacillus, The amount of Bifidobacterium in group B was 8.79 鹵2.31 脳 105 鹵2.28) 脳 1057.45 鹵2.28) 脳 1057.45 鹵2.28) 脳 1055.12 鹵2.47) 脳 105CFU 6.81 鹵1.86) 脳 105CFU 鹵1.62 鹵9.87 鹵1.68) 脳 10555.12 鹵2.20) 脳 105p / r 9.35 鹵2.20 脳 1055.35 鹵2.52 鹵1.82 鹵1.20 渭 mol / L, respectively. Conclusion the positive rate of rotavirus in intestinal tract in children with BICE is higher than that in control group. The number of probiotics and the ability of intestinal mucosal barrier were decreased, which may be related to the pathogenesis of BICE, but the pathogenetic mechanism is not clear.
【作者單位】： 南京醫(yī)科大學(xué)附屬兒童醫(yī)院;
【分類號】：R725.7;R742.1

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