本文關(guān)鍵詞： 小兒風(fēng)寒感冒 中醫(yī)治療 臨床研究 急性毒性實(shí)驗(yàn)　出處：《云南中醫(yī)學(xué)院》2014年碩士論文　論文類型：學(xué)位論文

【摘要】：目的：本文通過(guò)對(duì)參麻顆粒治療小兒風(fēng)寒感冒的療效進(jìn)行系統(tǒng)觀察和研究，探討該方的作用機(jī)制，，并通過(guò)急性毒性實(shí)驗(yàn)對(duì)參麻顆粒的安全性進(jìn)行初步評(píng)價(jià)，以尋求中醫(yī)藥治療小兒風(fēng)寒感冒的新思路。 方法:（1）本研究采用隨機(jī)單盲法將符合診斷標(biāo)準(zhǔn)的60例風(fēng)寒感冒患兒用數(shù)字隨機(jī)分組法分為參麻顆粒組（觀察組）和風(fēng)寒感冒顆粒組（對(duì)照組）,觀察組與對(duì)照組各30例，治療1-2個(gè)療程（3～6天），觀察并對(duì)比兩組患兒服藥后癥狀、體征的量化評(píng)分的改變情況，進(jìn)行綜合療效評(píng)定。（2）急性毒性實(shí)驗(yàn)在不能求得半數(shù)致死量的情況下，采用最大耐受量法求得小鼠1日的最大耐受量。 結(jié)果:（1）在總的療效比較方面，觀察組與對(duì)照組療效相當(dāng),差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。在改善臨床癥狀方面，觀察組對(duì)咳嗽等癥狀的改善優(yōu)于對(duì)照組。（2）急性毒性實(shí)驗(yàn)求得小鼠1日最大耐受量為生藥8.932g/kg，相當(dāng)于成人全日臨床推薦量的32.48倍，提示參麻顆粒臨床用藥安全。 結(jié)論:通過(guò)對(duì)參麻顆粒的臨床研究及急性毒性實(shí)驗(yàn)，證明參麻顆粒治療小兒風(fēng)寒感冒療效肯定，且該藥物無(wú)明顯毒副作用，值得推廣和應(yīng)用。
[Abstract]:Objective: to observe and study the therapeutic effect of Shenma granule on children with wind-cold colds, to explore the mechanism of its action, and to evaluate the safety of Shenma granule through acute toxicity experiment. In order to seek traditional Chinese medicine to treat children with cold cold new ideas. Methods in this study, 60 children with wind-cold cold were randomly divided into Shenma granule group (observation group) and wind cold cold granule group (control group) by random single blind method. There were 30 cases in the observation group and 30 cases in the control group, who were treated with 1-2 courses of treatment for 3 days or 6 days. The changes of the quantitative scores of symptoms and signs of the two groups were observed and compared. In the acute toxicity test, the maximum tolerance dose of mice in 1st was obtained by using the method of maximum tolerance dose under the condition that half lethal dose could not be obtained. Results compared with the control group, the curative effect of the observation group was similar to that of the control group, but the difference was not statistically significant (P 0.05). The improvement of cough and other symptoms in the observation group was better than that in the control group. (2) Acute toxicity test showed that the maximum tolerance dose in 1st was 8.932 g / kg crude drug. It is 32. 48 times that of adult clinical recommendation, suggesting that Shenma granule is safe in clinical use. Conclusion: through the clinical study and acute toxicity experiment of Shenma granule, it is proved that Shenma granule is effective in treating cold in children, and it has no obvious side effects, so it is worth popularizing and applying.
【學(xué)位授予單位】：云南中醫(yī)學(xué)院
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R272

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 舒尊鵬;胡書(shū)法;翟亞?wèn)|;周加林;王秋紅;匡海學(xué);;中藥枳殼化學(xué)成分及藥理作用研究[J];科技創(chuàng)新與應(yīng)用;2012年17期

2 陸定;劉詩(shī)強(qiáng);莊麗寶;龔淑珍;阮善;周穎;;肺炎支原體引起小兒上呼吸道感染的臨床研究[J];中國(guó)當(dāng)代兒科雜志;2006年03期

3 張侃,張玲娜,黎海芪,尹慶華,張慶,鄭惠連,楊曉波;6月～2歲小兒上呼吸道感染易感因素調(diào)查[J];兒科藥學(xué)雜志;1998年02期

4 陳麗;;珠珀猴棗散治療小兒上呼吸道感染療效觀察[J];兒科藥學(xué)雜志;2006年03期

5 原丹;施志強(qiáng);馬榕花;;肖詔瑋老中醫(yī)診治小兒感冒臨證經(jīng)驗(yàn)初探[J];福建中醫(yī)藥;2008年01期

6 龔兵,王永平,張小榮;銀連解毒湯治療小兒急性上呼吸道感染1566例療效觀察[J];甘肅中醫(yī);2004年12期

7 展銳;焦正花;王紅麗;李秀娟;王建良;;射干的藥理作用研究概況[J];甘肅中醫(yī);2011年01期

8 王東旭;;加味三仁湯治療小兒暑濕型感冒28例[J];廣西中醫(yī)藥;2006年05期

9 陳睿;張振尊;;蒿芩清膽湯加減治療小兒感冒100例臨床觀察[J];國(guó)醫(yī)論壇;2007年04期

10 鄧敏茹;葉志華;鄭婉君;;CRP NAP WBC DC的聯(lián)合檢測(cè)在兒童上呼吸道感染中的診斷價(jià)值[J];河北醫(yī)學(xué);2007年07期

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