本文關(guān)鍵詞： 精神分裂癥 驚跳反射抑制 兒茶酚-O-甲基轉(zhuǎn)移酶 多態(tài)性　出處：《中國(guó)心理衛(wèi)生雜志》2017年06期 　論文類型：期刊論文

【摘要】：目的:探討精神分裂癥患者兒茶酚-O-甲基轉(zhuǎn)移酶(COMT)第158位密碼子從纈氨酸到蛋氨酸的多態(tài)性(Vall58Met)與聽(tīng)覺(jué)驚跳反射抑制(PPI)的關(guān)系。方法:選取符合美國(guó)精神障礙診斷與統(tǒng)計(jì)手冊(cè)第4版(DSM-IV)的精神分裂癥患者178例,正常對(duì)照190例,使用SR-HLAB驚跳反射監(jiān)控系統(tǒng)測(cè)查聽(tīng)覺(jué)驚跳反射,其分析指標(biāo)包括:驚跳反射的反應(yīng)波幅(SR);驚跳反射的適應(yīng)性(HAB);時(shí)間間隔(LI)為30 ms、60 ms、120 ms時(shí)的聽(tīng)覺(jué)刺激驚跳反射弱刺激抑制(PPI30%、PPI60%、PPI120%);應(yīng)用聚合酶鏈反應(yīng)和限制性片段長(zhǎng)度多態(tài)性的方法,分析精神分裂癥組與對(duì)照組COMT Vall58Met基因型與等位基因分布頻率。結(jié)果:精神分裂癥組的波幅(SR)低于對(duì)照組[(563±460)mVvs.(695±447)m V,P0.05],適應(yīng)性(HAB)低于對(duì)照組[(32±46)vs.(48±33),P0.01],差異有統(tǒng)計(jì)學(xué)意義;精神分裂癥組與對(duì)照組之間PPI差異有統(tǒng)計(jì)學(xué)意義(F=7.15,P0.05),組與時(shí)間間隔的交互作用差異有統(tǒng)計(jì)學(xué)意義(F=5.57,P0.05),進(jìn)一步分析發(fā)現(xiàn)精神分裂癥組的%PPI120低于對(duì)照組[(27±5)vs.(35±3),P0.05]。2組間COMT基因型和等位基因分布有統(tǒng)計(jì)學(xué)意義(χ~2=8.16、11.74,均P0.05)。COMT三種基因型對(duì)HAB%的主效應(yīng)有統(tǒng)計(jì)學(xué)意義(F=3.07,P0.05);分組和COMT基因型對(duì)SR,HAB%,%PPI120的交互作用無(wú)統(tǒng)計(jì)學(xué)意義(F=1.64、2.87、2.26,均P0.05)。結(jié)論:COMT基因Vall58Met多態(tài)性可能與精神分裂癥的適應(yīng)性有關(guān),但與精神分裂癥PPI缺陷可能無(wú)關(guān)。
[Abstract]:Objective: to investigate the polymorphism of codon 158 from valine to methionine (Vall58 Metals) and auditory agitation reflex inhibition (ASRR) in schizophrenic patients with catechol-O-methyltransferase (COMT). Methods: 178 schizophrenic patients who were in accordance with the fourth edition of the American Handbook for the diagnosis and Statistics of Mental Disorders (DSM-IV) were selected. In the normal control group, SR-HLAB reflex monitoring system was used to detect the auditory shock reflex. The analysis indexes included: the response amplitude of the shock reflex; The adaptability of jumping reflex to HABN; The auditory stimuli at intervals of 30 Ms ~ 60 Ms ~ 120 Ms inhibited PPI30 and PPI _ (60) and PPI _ (120). Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) were used. The frequency of COMT Vall58Met genotype and allele distribution in schizophrenia group and control group were analyzed. Results: the amplitude of COMT Vall58Met in schizophrenia group was lower than that in control group. [563 鹵460mVvs.695 鹵447mVV (P0.05), and the adaptive HABs were lower than those in the control group (P < 0.05). [The difference was statistically significant (32 鹵46 vs. 48 鹵33 P0.01). The difference of PPI between the schizophrenia group and the control group was statistically significant (P 0.05), and the interaction between the group and the time interval was significantly different (P = 5.57). Further analysis showed that PPI120 in schizophrenia group was lower than that in control group. [The distribution of COMT genotypes and alleles was statistically significant (蠂 ~ 2 = 8.16, 11.74) among the groups (27 鹵5) vs.35 鹵3 (P0.05). The main effect of all three genotypes on HB% was significant (P < 0.05). There was no significant difference in the interaction between the subgroup and COMT genotype on PPI120. Conclusion the Vall58Met polymorphism of the 1: COMT gene may be related to the adaptability of schizophrenia, but it may not be related to the PPI deficiency in schizophrenia.
【作者單位】： 北京回龍觀醫(yī)院;北京大學(xué)第六醫(yī)院 北京大學(xué)精神衛(wèi)生研究所 衛(wèi)生部精神衛(wèi)生學(xué)重點(diǎn)實(shí)驗(yàn)室(北京大學(xué));
【分類號(hào)】：R749.3
【正文快照】： 京大學(xué)),北京100191通信作者:譚云龍yltan21@126.com;周東豐Zhoudf@bjmuedu.cn)(中國(guó)心理衛(wèi)生雜志,2017,31(6):436-441.)Corresponding author:TAN Yun-Long,yltan21@126.com;ZHOU Dong-Feng,Zhoudf@bjmuedu.cnCOMT Vall58M et polymorphism w as genotyped by polymerase cha

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