本文關(guān)鍵詞： CD 急性B淋巴細胞白血病 兒童 成人 免疫分型　出處：《中國實驗血液學(xué)雜志》2017年01期 　論文類型：期刊論文

【摘要】：目的:探討CD146在兒童與成人急性B淋巴細胞白血病(B-ALL)細胞中表達的差異及其與其他抗原、臨床、分子生物學(xué)及細胞遺傳學(xué)特征的關(guān)系。方法:應(yīng)用流式細胞儀檢測CD146在兒童(44例)與成人(24例)BALL中的表達情況,并分析CD146異常高表達與性別、初診時外周血血象、骨髓原始淋巴細胞與幼稚淋巴細胞比例等參數(shù)的關(guān)系,比較CD146與其他抗原之間的相關(guān)性,以及CD146異常高表達患者1個療程的緩解率。結(jié)果:成人B-ALL中CD146異常高表達率為29.17%(7/24),兒童B-ALL中CD146異常高表達率為9.09%(4/44),在成人組顯著高于兒童組(P0.05);在成人組中CD146與CD64(r=0.491,P0.05)和CD117(r=0.578,P0.05)呈正相關(guān)關(guān)系,在兒童組中CD146與CD71(r=0.419,P0.01)、CD58(r=0.301,P0.05)呈正相關(guān)關(guān)系;經(jīng)1個療程的正規(guī)化療后,異常高表達CD146的成人組和兒童組的緩解率均低(P0.05)。結(jié)論:成人B-ALL患者的CD146表達率高于兒童B-ALL患者。CD146與預(yù)后較差的抗原呈正相關(guān)。CD146可能是一個預(yù)后不良的指標(biāo)。
[Abstract]:Objective: to investigate the expression of CD146 in children and adults with acute B lymphoblastic leukemia (ALL) cells and its clinical significance with other antigens. Methods: flow cytometry was used to detect the expression of CD146 in 44 children (n = 44) and adults (n = 24). The relationship between the abnormal high expression of CD146 and sex, the blood picture of peripheral blood, the proportion of bone marrow primitive lymphocytes and immature lymphocytes were analyzed, and the correlation between CD146 and other antigens was compared. Results: the abnormal high expression rate of CD146 in adult B-ALL was 29.17 / 24). The abnormal high expression rate of CD146 in children with B-ALL was 9.09 / 44%, which was significantly higher in adults than in children (P 0.05). There was a positive correlation between CD146 and CD64 rhombus (P 0.05) and CD117R (0.578N P 0.05) in adult group. There was a positive correlation between CD146 and CD71rU 0.419 (P0.01P0.01) in the children group (P 0.05), and there was a positive correlation between CD146 and CD71P0.01P0.05in the children's group. After one course of regular chemotherapy. The remission rates of both adults and children with abnormal high expression of CD146 were low (P0.05). Conclusion: the expression rate of CD146 in adult B-ALL patients is higher than that in children B-ALL patients.
【作者單位】： 鄭州大學(xué)第一附屬醫(yī)院血液科;
【分類號】：R733.71
【正文快照】： 急性B淋巴細胞白血病(B-ALL)是一種原始和幼稚淋巴細胞克隆性為主的惡性疾病,是嚴(yán)重危害人類的一種常見的造血系統(tǒng)疾病。ALL在兒童急性白血病中占80%,而在成人中占25%,經(jīng)治療后兒童長期無病生存率達80%,而成人只有30%- 40%[11。在B-ALL中,成人與兒童抗原表達不完全相同[2],CD

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本文編號：1467110