本文關鍵詞：雄性激素在嬰兒肛周膿腫發(fā)病中的作用及機制探討　出處：《重慶醫(yī)科大學》2013年碩士論文　論文類型：學位論文

  更多相關文章： 雄激素 肛腺 嬰兒肛周膿腫

【摘要】：目的：研究肛周膿腫患兒血清總睪酮（T）、雄烯二酮（ADSD）、脫氫表雄酮（DHEA）水平與肛周膿腫（PA）發(fā)病的關系，并探討嬰兒肛周膿腫的發(fā)病機制。 方法：前瞻性研究，隨機選取重慶醫(yī)科大學附屬兒童醫(yī)院胃腸、新生兒外科2009年12月-2012年8月住院的肛周膿腫男性患兒100例為實驗組，并選取年齡3月以下的腹股溝疝（無嵌頓史）男性患兒11例為對照組。采用化學發(fā)光法測定其血清T、ADSD、DHEA濃度。運用SPSS19.0軟件進行統(tǒng)計學處理，將實驗組T、ADSD、DHEA值與對照組作相關性分析。 結果：實驗組患兒血清T水平8.01±4.29nmol/L較正常對照組的4.55±1.23nmol/L明顯升高，差異有統(tǒng)計學意義(t=2.65，P0.05)；血清ADSD水平16.11±9.55nmol/L較正常對照組的6.78±2.30nmol/L明顯升高，差異有統(tǒng)計學意義(t=3.21，P0.05)；血清DHEA水平1.70±1.21nmol/L較正常對照組的1.23±0.65nmol/L無明顯升高，差異無統(tǒng)計學意義(t=1.24，P＞0.05)。 結論：嬰兒期雄性激素增高，，包括一過性雄性激素增高及從母體攜帶的雄性激素�？蓪е赂叵僭錾头置谕�，粘液排泄不暢而堵塞腺導管。嬰兒本身肛門直腸粘膜局部免疫結構未成熟，防御能力薄弱易受感染，感染通過肛腺（AG）逐漸蔓延至肛管直腸周圍形成膿腫。故雄性激素增高可能與嬰兒肛周膿腫的發(fā)病相關。
[Abstract]:Objective: to study the relationship between the levels of serum total testosterone (TX), androstenedione (ADSD), dehydroepiandrosterone (DHEAA) and the incidence of perianal abscess (PAA) in children with perianal abscess. To explore the pathogenesis of perianal abscess in infants. Methods: prospective study randomly selected 100 male children with perianal abscess hospitalized in the affiliated Children's Hospital of Chongqing Medical University from December 2009 to August 2012 as the experimental group. Eleven male children with inguinal hernia (no history of incarceration) under March were selected as the control group and their serum Tach-ADSD was determined by chemiluminescence method. The concentration of DHEA was analyzed by SPSS19.0 software, and the correlation analysis was made between the experimental group and the control group. Results: the serum T level in the experimental group was 8.01 鹵4.29 nmol / L, which was significantly higher than that in the normal control group (4.55 鹵1.23 nmol / L). The difference was statistically significant (P 0.05). The serum ADSD level was 16.11 鹵9.55nmol / L and 6.78 鹵2.30nmol / L in normal control group, and the difference was statistically significant. P0.05; The serum DHEA level was 1.70 鹵1.21 nmol / L and 1.23 鹵0.65 nmol / L in normal control group, and the difference was not statistically significant. P > 0.05. Conclusion: the increase of male hormone in infancy, including transient increase of androgen and androgen carried from mother, can lead to proliferation and exuberant secretion of anal gland. The mucus excretion is not smooth and the gland duct is blocked. The local immune structure of the baby's anorectal mucosa is immature and the defenses are weak and vulnerable to infection. The infection spread to the perianal abscess through the anus gland AGV, so the increase of androgen may be related to the development of perianal abscess in infants.
【學位授予單位】：重慶醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2013
【分類號】：R725.7

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