本文關(guān)鍵詞：維生素D缺乏性佝僂病與嬰幼兒反復(fù)呼吸道感染的相關(guān)性研究　出處：《青島大學(xué)》2013年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 嬰幼兒反復(fù)呼吸道感染 佝僂病 25-(OH)D 骨堿性磷酸酶(BALP)

【摘要】：目的探討維生素D缺乏性佝僂病與嬰幼兒反復(fù)呼吸道感染的臨床關(guān)系。 方法選擇2012年3月至2012年9月在費(fèi)縣人民醫(yī)院兒科就診的60例反復(fù)呼吸道感染的嬰幼兒為觀察組,同期在兒童保健門診體檢的60例相同年齡段的健康嬰幼兒作為對(duì)照組,2組均取清晨空腹血進(jìn)行血清骨堿性磷酸酶及25-(OH)D的檢測(cè),對(duì)兩組數(shù)據(jù)進(jìn)行統(tǒng)計(jì)學(xué)分析,觀察佝僂病在反復(fù)呼吸道感染患兒及正常體檢兒童中的患病率情況,從而探討維生素D缺乏性佝僂病與嬰幼兒反復(fù)呼吸道感染的關(guān)聯(lián)性,并用維生素D及鈣劑對(duì)佝僂病及其亞臨床狀態(tài)的患兒進(jìn)行治療,進(jìn)行半年跟蹤隨訪。 結(jié)果1對(duì)反復(fù)呼吸道感染組和正常健康體檢兒組佝僂病患病率進(jìn)行統(tǒng)計(jì)學(xué)處理,差異有顯著性(x2=14.79,P0.01)；RRI組和對(duì)照組維生素D缺乏亞臨床狀態(tài)發(fā)生率進(jìn)行統(tǒng)計(jì)學(xué)處理,差異無顯著性(x2=2.68,P0.05)。 2將兩組BALP檢測(cè)結(jié)果進(jìn)行比較,RRI組BALP250U/L的比率明顯高于對(duì)照組,對(duì)兩者數(shù)據(jù)進(jìn)行統(tǒng)計(jì)學(xué)處理,差異有顯著性(x2=15.96,P0.01)。 3兩組患兒25-(OH)D測(cè)試結(jié)果分析,RRI組25-(OH)D降低比率明顯高于對(duì)照組,經(jīng)統(tǒng)計(jì)學(xué)分析,兩組數(shù)據(jù)差異有顯著性(x2=14.79, P0.01)。 4反復(fù)呼吸道感染組佝僂病患兒和維生素D缺乏亞臨床狀態(tài)患兒均給予維生素D,半年后復(fù)查,其呼吸系統(tǒng)反復(fù)感染性疾病的發(fā)病率和治療前相比,有明顯減少。 結(jié)論1反復(fù)呼吸道感染組佝僂病患病率明顯高于正常體檢兒童組,即嬰幼兒反復(fù)呼吸道感染與佝僂病具有臨床關(guān)聯(lián)性。 2積極防治佝僂病可以降低嬰幼兒反復(fù)呼吸道感染的患病率。
[Abstract]:Objective to investigate the clinical relationship between vitamin D deficiency rickets and recurrent respiratory tract infection in infants. Methods 60 infants with recurrent respiratory tract infection from March 2012 to September 2012 in Fexian people's Hospital were selected as observation group. In the same period, 60 healthy infants of the same age were taken as the control group and fasting blood samples were taken to detect serum alkaline phosphatase and OHH D in the same period. The data of the two groups were statistically analyzed to observe the prevalence of rickets in children with recurrent respiratory tract infection and healthy children. The relationship between vitamin D deficiency rickets and recurrent respiratory tract infection in infants was discussed. The children with rickets and its subclinical status were treated with vitamin D and calcium, followed up for half a year. Results 1the prevalence rate of rickets in the recurrent respiratory tract infection group and the normal health check group was statistically analyzed, and the difference was significant (P 0.01). The incidence of subclinical status of vitamin D deficiency in RRI group and control group was statistically analyzed. There was no significant difference in subclinical status between RRI group and control group. 2Compared the results of BALP detection in the two groups, the ratio of BALP250U/L in the RRI group was significantly higher than that in the control group, and the two data were statistically processed. The difference was significant (P 0.01). 3The results of 25-OHH D test in the two groups were significantly higher than those in the control group (P < 0.05), and the decrease rate of OHH D in RRI group was significantly higher than that in the control group (P < 0.05). There was significant difference between the two groups (P < 0.01). 4 the children with rickets and subclinical status of vitamin D deficiency were given vitamin D in the group of repeated respiratory tract infection, and the incidence of recurrent infectious diseases of the respiratory system was compared with that before treatment. There is a marked decrease. Conclusion 1 the prevalence rate of rickets in recurrent respiratory tract infection group was significantly higher than that in normal children group, that is, there was a clinical correlation between recurrent respiratory tract infection and rickets in infants. 2 active prevention and treatment of rickets can reduce the prevalence of recurrent respiratory tract infection in infants.
【學(xué)位授予單位】：青島大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2013
【分類號(hào)】：R725.6;R723.2

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