發(fā)布時(shí)間：2018-11-20 04:07

【摘要】：新生仔豬腹瀉病已經(jīng)成為影響當(dāng)今養(yǎng)豬產(chǎn)業(yè)發(fā)展的主要疾病之一,其特點(diǎn)是新生仔豬發(fā)病快,死亡率高,已經(jīng)嚴(yán)重的危害著養(yǎng)豬產(chǎn)業(yè)的經(jīng)濟(jì)效益。本研究擬優(yōu)化復(fù)方小檗堿膏劑的組方及制備工藝,初步建立其質(zhì)量標(biāo)準(zhǔn),并進(jìn)行安全性評(píng)價(jià)及臨床療效的研究,結(jié)果表明:(1)復(fù)方小檗堿膏劑主要成分為鹽酸小檗堿、穿心蓮內(nèi)酯及納米蒙脫石,穿心蓮內(nèi)酯在與無(wú)水乙醇比值為1:5,甘油含量5m L,溫度為65℃的情況下,穿心蓮內(nèi)酯的溶解性好,粘稠度高;急性毒性實(shí)驗(yàn)結(jié)果顯示其不具有毒性作用;微生物限度、粒子大小、最低裝量及穩(wěn)定性均符合國(guó)家相關(guān)規(guī)定。(2)復(fù)方小檗堿膏劑對(duì)妊娠母豬及新生仔豬的血液生化指標(biāo)無(wú)顯著影響,各項(xiàng)數(shù)值均在正常范圍之內(nèi),表明其對(duì)妊娠母豬及新生仔豬的肝臟功能、腎臟功能及生理功能無(wú)影響。(3)復(fù)方小檗堿膏劑可以使產(chǎn)后母豬恢復(fù)食欲,預(yù)防乳房炎,促進(jìn)乳汁的分泌;復(fù)方小檗堿膏劑對(duì)妊娠母豬的后代具有促進(jìn)生長(zhǎng)的作用,精神狀態(tài)良好,被毛光亮,食欲正常;復(fù)方小檗堿膏劑對(duì)新生仔豬具有促生長(zhǎng)的作用,增強(qiáng)了新生仔豬的抗腹瀉能力。(4)復(fù)方小檗堿膏劑對(duì)新生仔豬腹瀉病具有治療作用,與西藥治療腹瀉藥物相比,其能夠快速補(bǔ)能,提高仔豬精神狀態(tài),加快食欲恢復(fù),防止仔豬脫水死亡,降低死亡率。綜上所述,復(fù)方小檗堿膏劑制備工藝穩(wěn)定,質(zhì)量標(biāo)準(zhǔn)合格,安全可靠,其臨床療效作用明顯,具有可靠的臨床應(yīng)用前景。
[Abstract]:Diarrhea disease of newborn piglets has become one of the main diseases affecting the development of pig raising industry. Its characteristics are that newborn piglets have a fast onset and a high mortality rate, which has seriously jeopardized the economic benefits of the pig industry. This study aims to optimize the formulation and preparation process of compound berberine paste, establish its quality standard, evaluate its safety and clinical efficacy. The results show that: (1) berberine hydrochloride is the main component of compound berberine paste. When the ratio of andrographolide to anhydrous ethanol is 1: 5, glycerol content is 5m L, temperature is 65 鈩，

本文編號(hào)：2343658