本文選題：黨參多糖口服液 + 大鼠��； 參考：《中國(guó)獸藥雜志》2016年12期

【摘要】：為了解長(zhǎng)期使用黨參多糖口服液對(duì)機(jī)體的毒性反應(yīng),以便指導(dǎo)臨床長(zhǎng)期用藥的安全性。大鼠灌胃給藥黨參多糖口服液,在給藥4周和停藥2周內(nèi),觀察大鼠一般行為活動(dòng)等情況,進(jìn)行血液學(xué)、血液生化學(xué)和主要臟器病理學(xué)檢查,考察黨參多糖口服液給藥的長(zhǎng)期毒性。結(jié)果顯示,各組大鼠在給藥期間和恢復(fù)期內(nèi),一般情況和行為活動(dòng)、糞便等均無(wú)異常變化,血液學(xué)、血液生化學(xué)和主要臟器病理學(xué)檢查,均無(wú)明顯變化。因此,連續(xù)大鼠灌胃給藥黨參多糖口服液未見(jiàn)明顯毒性反應(yīng),說(shuō)明黨參多糖口服液具有較高的臨床用藥安全性。
[Abstract]:In order to understand the toxicity of Codonopsis polysaccharides oral liquid to the body and to guide the safety of clinical long-term drug use. The rats were given Codonopsis polysaccharide oral liquid by gavage. During 4 weeks of administration and 2 weeks of withdrawal, the general behavior of rats was observed, and blood, blood biochemistry and pathology of main organs were examined. To investigate the long-term toxicity of Codonopsis polysaccharide oral liquid. The results showed that there were no abnormal changes in general condition, behavior, feces and so on during the administration and convalescence of the rats in each group, but there were no significant changes in hematology, blood biochemistry and pathological examination of main organs. Therefore, continuous administration of Codonopsis pilosula polysaccharide oral liquid showed no obvious toxic reaction, which indicated that Codonopsis polysaccharide oral liquid had higher clinical safety.
【作者單位】： 山西省獸藥監(jiān)察所;河南省獸藥監(jiān)察所;中國(guó)獸醫(yī)藥品監(jiān)察所;江西新世紀(jì)民星動(dòng)物保健品有限公司;
【分類(lèi)號(hào)】：S853.7

【相似文獻(xiàn)】

相關(guān)期刊論文 前3條

1 曹授俊;鮑杰;王金秋;孫健;馬建民;;Fru.G提取物對(duì)大鼠血象長(zhǎng)期毒性影響的研究[J];黑龍江畜牧獸醫(yī);2012年15期

2 ;警惕假冒“增長(zhǎng)樂(lè)”沖劑[J];現(xiàn)代農(nóng)業(yè);1992年10期

3 ;[J];;年期

相關(guān)會(huì)議論文 前10條

1 程艷玲;武復(fù)榮;馬新宇;;氯替潑諾家犬長(zhǎng)期毒性研究[A];中國(guó)藥理學(xué)會(huì)制藥工業(yè)專(zhuān)業(yè)委員會(huì)第十一屆學(xué)術(shù)會(huì)議論文摘要匯編[C];2004年

2 程艷玲;武復(fù)榮;田月潔;劉兆平;;515大鼠長(zhǎng)期毒性研究[A];中國(guó)藥理學(xué)會(huì)第九屆制藥工業(yè)藥理學(xué)術(shù)會(huì)議論文摘要匯編[C];2000年

3 袁守軍;張宏濤;徐蘭平;田增月;韓昌明;丁林茂;;抗老年癡呆化合物9714的比格犬長(zhǎng)期毒性研究以及伴隨毒代動(dòng)力學(xué)和毒理基因組學(xué)的初步研究[A];中國(guó)藥理學(xué)會(huì)毒理專(zhuān)業(yè)委員會(huì)第十次學(xué)術(shù)會(huì)議論文摘要匯編[C];2004年

4 來(lái)慶勤;肖t，

本文編號(hào)：1978911