本文選題：犬高血糖癥 + 血鈣　； 參考：《西北農(nóng)林科技大學》2017年碩士論文

【摘要】：高血糖癥是由于血糖升高而引起的一種代謝綜合征。臨床上,當犬的血糖濃度高于7.3 mmol/L(130 mg/dL)時,就認為存在犬高血糖癥。高血糖是糖尿病的重要指標,也是誘發(fā)糖尿病以及肝臟、腎臟和心血管疾病的重要因素。近年來,機體內(nèi)元素與代謝綜合征發(fā)生發(fā)展關(guān)系的研究層出不窮,人醫(yī)上已經(jīng)有很多關(guān)于糖尿病患者血液中元素代謝失衡的研究,但是獸醫(yī)臨床上對這方面的研究還很缺乏。本論文旨在探討高血糖患犬是否存在血鈣、血磷或血鎂的代謝異常,以期為臨床高血糖患犬的管理及其相關(guān)繼發(fā)癥的防治提供新的研究思路。論文收集了臺灣中興大學獸醫(yī)教學醫(yī)院2015年1月至2016年10月近2年患犬的門診病例資料。根據(jù)病史、臨床檢查、實驗室檢查和特殊檢查等病例資料進行篩選,排除患有惡性腫瘤、骨質(zhì)疏松、嚴重胃腸道疾病、酮癥酸中毒和嚴重腎臟疾病等病例。最終將血糖正常(70~120 mg/dL)且各項檢查均無明顯異常的110例犬作為對照組。將血糖濃度高于130 mg/dL,臨床上未診斷出糖尿病的119例患犬作為非糖尿病高血糖組。將血糖濃度高于200 mg/dL,臨床上確診為糖尿病的22例患犬作為糖尿病高血糖組。通過統(tǒng)計學分析方法比較了三組不同血糖水平犬的血鈣、血磷和血鎂水平之間的差異,并對血糖與血鈣、血磷和血鎂水平之間的相關(guān)性進行了分析。結(jié)果顯示:非糖尿病高血糖組的血鈣顯著低于對照組(p0.05),而血鎂和血磷在兩組間無顯著性差異(p0.05);糖尿病高血糖組的血鈣和血鎂均顯著低于對照組(p0.05),而血磷在兩組間無顯著性差異(p0.05)。血糖與血鈣、血鎂呈顯著的負相關(guān)性(p0.05,r=-0.320,-0.152),與血磷呈顯著的正相關(guān)性(p0.05,r=0.124),其中血糖與血鈣的相關(guān)性最顯著。結(jié)果表明,高血糖患犬存在血鈣、血鎂和血磷的代謝異常。作者認為在高血糖患犬中,通過密切監(jiān)測血鈣、血鎂和血磷的濃度變化,適當?shù)亟o患犬補充鈣、鎂制劑和維生素D可能有利于改善高血糖患犬的預(yù)后,對高血糖患犬給予適量的排磷藥物可能有利于延緩高血糖對腎臟的損傷。
[Abstract]:Hyperglycemia is a metabolic syndrome caused by elevated blood sugar. Clinically, canine hyperglycemia is thought to exist when blood glucose levels are higher than 7.3 mmol/L(130 mg / dL. Hyperglycemia is an important indicator of diabetes and an important factor in inducing diabetes as well as liver, kidney and cardiovascular disease. In recent years, there have been many studies on the relationship between elements and metabolic syndrome in the body. There have been many studies on the imbalance of element metabolism in the blood of patients with diabetes mellitus. However, there is still a lack of research on this aspect in veterinary clinic. The purpose of this study was to investigate the metabolic abnormalities of serum calcium, phosphorus or magnesium in dogs with hyperglycemia, in order to provide a new approach for the management of hyperglycemic dogs and the prevention and treatment of related secondary disorders. The paper collected the outpatient cases of dogs from January 2015 to October 2016 in the Veterinary Teaching Hospital of ZTE University in Taiwan. Cases of malignant tumor, osteoporosis, severe gastrointestinal diseases, ketoacidosis and severe renal diseases were excluded according to the history, clinical examination, laboratory examination and special examination. In the end, 110 dogs with normal blood glucose (70 mg / dL) and no obvious abnormal examination were taken as the control group. A total of 119 dogs with no diabetes were treated as non-diabetic hyperglycemia group with blood glucose concentration higher than 130 mg / dL. Twenty-two dogs with diabetes were selected as diabetic hyperglycemia group, whose blood glucose level was higher than 200 mg / dL. The differences of serum calcium, phosphorus and magnesium levels among three groups of dogs with different blood glucose levels were compared by statistical analysis, and the correlation between blood glucose and serum calcium, phosphorus and magnesium levels was analyzed. The results showed that the level of serum calcium in the non-diabetic hyperglycemia group was significantly lower than that in the control group (P 0.05), but there was no significant difference in serum magnesium and phosphorus between the two groups, while the levels of serum calcium and magnesium in the diabetic hyperglycemia group were significantly lower than those in the control group (P 0.05), but there was no significant difference in serum phosphorus between the two groups. There was a significant negative correlation between blood glucose and blood calcium, and a significant negative correlation between blood magnesium and blood glucose, and a significant positive correlation between blood glucose and serum phosphorus, among which the correlation between blood glucose and serum calcium was the most significant. The results showed that there were abnormal metabolism of serum calcium, magnesium and phosphorus in dogs with hyperglycemia. The authors suggest that the proper supplement of calcium, magnesium and vitamin D may be helpful to improve the prognosis of hyperglycemic dogs by closely monitoring the changes of serum calcium, magnesium and phosphorus concentrations. Proper dose of phosphorus excretion in hyperglycemic dogs may be beneficial to delay renal damage caused by hyperglycemia.
【學位授予單位】：西北農(nóng)林科技大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：S858.292

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