本文選題：當(dāng)歸顆粒劑 + 煎劑��； 參考：《動(dòng)物醫(yī)學(xué)進(jìn)展》2017年02期

【摘要】：為了比較當(dāng)歸顆粒劑與煎劑在有效成分和藥效上的差異,采用薄層色譜法(TLC)鑒定當(dāng)歸顆粒劑;高效液相色譜法(HPLC)測(cè)定顆粒劑、煎劑和對(duì)照藥材中阿魏酸的含量;應(yīng)用《中藥色譜指紋圖譜相似度評(píng)價(jià)》軟件對(duì)顆粒劑、煎劑進(jìn)行相似度評(píng)價(jià),同時(shí)進(jìn)行體外抑菌試驗(yàn)。結(jié)果表明,當(dāng)歸顆粒劑TLC圖中存在當(dāng)歸對(duì)照藥材的特征斑點(diǎn),與對(duì)照藥材HPLC特征圖譜相似度達(dá)95.1%;顆粒劑、煎劑和對(duì)照藥材中阿魏酸的含量分別為3.95、1.69、2.84mg/g;抑菌結(jié)果為金黃色葡萄球菌、沙門菌抑菌圈顆粒劑和煎劑相同,大腸埃希菌、鏈球菌抑菌圈顆粒劑煎劑。通過試驗(yàn)發(fā)現(xiàn),當(dāng)歸顆粒劑中有效成分與對(duì)照藥材相近,體外抑菌結(jié)果優(yōu)于煎劑。
[Abstract]:In order to compare the difference between Danggui granules and decoction in effective components and pharmacodynamics, TLC was used to identify Danggui granules, and HPLC was used to determine the content of ferulic acid in granules, decoction and control. The similarity evaluation of granules and decoction was carried out with the software of similarity Evaluation of chromatographic fingerprint of traditional Chinese Medicine (TCM), and the bacteriostatic test in vitro was carried out at the same time. The results showed that there were characteristic spots in the TLC map of Danggui granules, and the similarity between the HPLC characteristic maps of Danggui granules and the control herbs was 95.1.The content of ferulic acid in granules, decoction and control was 3.95.69 mg / g, 2.84 mg / g, respectively, and the bacteriostatic effect was Staphylococcus aureus. Salmonella bacteriostatic circle granules and decoction are the same, Escherichia coli, Streptococcus bacteriostatic circle granules decoction. The results showed that the effective components of Danggui granules were similar to those of the control, and the bacteriostatic effect was superior to that of decoction in vitro.
【作者單位】： 寧夏大學(xué)農(nóng)學(xué)院;寧夏回族自治區(qū)藥品檢驗(yàn)所;銀川第二人民醫(yī)院藥劑科;
【分類號(hào)】：S853.7

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本文編號(hào)：1869920