本文選題：犬瘟熱病毒 + 患犬　； 參考：《河南科技大學(xué)》2017年碩士論文

【摘要】：目的犬瘟熱病毒(Canine distemper virus,CDV)長期以來因其強(qiáng)傳染力,高致死力,而被譽(yù)為犬類的第1號致死性疾病。盡管隨著寵物醫(yī)療藥物、技術(shù)及設(shè)備的進(jìn)步,CDV的治愈率雖有所提高,但治愈率仍很低下,主要體現(xiàn)在CDV對機(jī)體的損害是多系統(tǒng)多器官性的,且治療方案多為對癥治療。迄今為止,CDV發(fā)病時期器官功能學(xué)研究較少。機(jī)體各系統(tǒng)的功能變化不清,可能是導(dǎo)致治愈率低的主要原因之一。本課題對CDV患犬在治療中各種臟器生化的指標(biāo)變化進(jìn)行了系統(tǒng)的研究,旨在弄清CDV患犬生化指標(biāo)的變化及意義,闡明其相關(guān)機(jī)制,為CDV臨床治療提供指導(dǎo),進(jìn)而提高CDV的治愈率。方法(1)試驗設(shè)計:本研究以洛陽市某寵物醫(yī)院前來就診的CDV患犬為實驗組,以體檢且健康的犬為對照組,進(jìn)行血清生化指標(biāo)的連續(xù)的系統(tǒng)的監(jiān)測。分析其生化單項指標(biāo)的總體變異率及升降關(guān)系,生化指標(biāo)功能的變化規(guī)律,以及CDV痊愈犬與死亡犬生化指標(biāo)的對比,來找出CDV與各生化指標(biāo)的相關(guān)性。(2)數(shù)據(jù)處理:?單項指標(biāo)總體變異率:在檢測報告單中,指標(biāo)超出參考范圍上限值或低于下限值,計為變異1次,對所有樣本每個生化指標(biāo)做累加處理,即得變異樣本總數(shù)。然后,將變異樣本總數(shù)除以樣本總數(shù),即為變異樣本率;?生化指標(biāo)功能變化率:將生化檢測報告數(shù)據(jù),按其功能性歸為肝功,腎功,心功,胰功,血清鈣,以及蛋白六類。所測指標(biāo)超出參考范圍上限值或低于下限值,計為變異1次,對所有樣本每項指標(biāo)做累加處理,即為變異樣本總數(shù)。然后,將變異樣本總數(shù)除以樣本總數(shù),即為變異樣本率;?CDV痊愈犬與死亡犬生化指標(biāo)的對比:實驗分痊愈,死亡,對照三組。將每組每項生化指標(biāo)值匯總后取平均值,用統(tǒng)計軟件進(jìn)行組間差異顯著性分析。結(jié)果(1)CDV病例生化指標(biāo)的單項變異率的臨界值約為30%。變異率30%的有ALP、CK、r-GT、TBIL、Ca、ALB、AST、P、TP、CREA,這些生化指標(biāo)有顯著統(tǒng)計學(xué)意義(P0.05);變異率30%的指標(biāo)有TC、LIP、GLB、ALT、GLU、UREA、TG、AMY,這些生化指標(biāo)對犬瘟病例治療及預(yù)后的影響不大,無統(tǒng)計學(xué)意義。(2)CDV病例臟器生化功能變異率的臨界值是40%;若變異率≥40%,說明臟器功能有顯著變化,顯著性變化的臟器(指標(biāo))有心功、血清鈣、肝功、蛋白質(zhì)、腎功。若臟器功能變異率40%,說明臟器功能變化不顯著。無顯著變化臟器(指標(biāo))有胰腺功能、血糖血脂。(3)對痊愈組與死亡組進(jìn)行對比結(jié)果顯示,有顯著性差異的是胰腺功能降低、血清鈣濃度下降及蛋白質(zhì)缺乏,這可能是導(dǎo)致CDV患犬最終死亡的主要原因。結(jié)論結(jié)果表明,CDV患犬在治療期間,應(yīng)及時監(jiān)測ALP、CK、r-GT、TBIL、Ca、ALB、AST、P、TP、CREA等生化指標(biāo),以及胰腺功能、血清鈣及蛋白質(zhì)指標(biāo)的變化,根據(jù)檢測指標(biāo),隨時調(diào)整臨床用藥,可能會提高CDV的治療率,降低死亡率。
[Abstract]:Objective canine distemper virus (canine distemper virus) has long been regarded as the first fatal disease of dogs because of its strong infectivity and high lethal power. Although the cure rate of CDV has been improved with the progress of pet medicine, technology and equipment, the cure rate is still very low, which is mainly reflected in the fact that the damage of CDV to the body is multi-system and multi-organ, and most of the treatment schemes are symptomatic. So far, there are few studies on organ function during the onset of CDV. Unclear functional changes in the system may be one of the main causes of low cure rate. In this paper, the changes of biochemical indexes of various organs in dogs with CDV were studied systematically. The purpose of this study was to clarify the changes and significance of biochemical indexes in dogs with CDV, to clarify the related mechanism, and to provide guidance for the clinical treatment of CDV. Then the cure rate of CDV was improved. Methods 1) the experimental design: the CDV dogs in a pet hospital in Luoyang were used as the experimental group and the healthy dogs as the control group. The serum biochemical indexes were monitored systematically and continuously. In order to find out the correlation between CDV and each biochemical index, the relationship between the total variation rate and the rise and fall of the single biochemical index, the change rule of the biochemical index function, and the comparison between the biochemical index of CDV cured dog and dead dog were analyzed to find out the correlation between CDV and each biochemical index. The total variation rate of single index: in the test report sheet, the index exceeds the upper limit value of reference range or below the lower limit value, it is counted as variation one time, for each biochemical index of all samples to do cumulative processing, that is, the total number of variation samples. Then, divide the total number of samples by the total number of samples, that is, the sample rate of variation? The change rate of biochemical index function: according to its function, the data reported by biochemical test were classified as liver function, kidney function, heart function, pancreatic function, serum calcium and protein. If the measured index exceeds the upper limit of the reference range or is below the lower limit, it is counted as one variation, and the total number of variation samples is added to each index of all samples. Then, the total number of variation samples was divided by the total number of samples, that is, the rate of variation sample was compared with the biochemical indexes of CDV cured dogs and dead dogs: the experiment was divided into three groups: recovery, death and control. The average value of each biochemical index in each group was collected and the statistical software was used to analyze the significance of the difference between groups. Results the critical value of single variation rate of CDV was about 30%. The rate of variation was 30% in ALP CK r-GTT TBILA, and the biochemical indexes were statistically significant (P 0.05), and the variation rate was 30% in TCU LIPGLBALBALL GLUEAEAA TGAMY.These biochemical indexes had little effect on the treatment and prognosis of canine plague. The results showed that the biochemistry parameters had no significant effect on the treatment and prognosis of canine plague patients, and the variation rate of 30% was higher than that of the control group (P < 0.05). The results showed that there was no significant difference in the treatment and prognosis of canine plague patients. The critical value of organ biochemical function variation rate in CDV patients with no statistical significance was 40. If the variation rate was greater than 40, it indicated that the organ function had significant changes, and the organs (indexes) with significant changes had heart function, serum calcium, liver function, protein and kidney function. If the variation rate of organ function is 40%, the change of organ function is not significant. No significant changes were found in organs (indicators) with pancreatic function, blood glucose, blood lipid and blood lipid. The results of comparison between the cured group and the dead group showed that the pancreatic function was decreased, the serum calcium concentration was decreased and the protein deficiency was found in the cured group. This may be the leading cause of death in dogs with CDV. Conclusion during the treatment period, the changes of biochemical indexes, pancreatic function, serum calcium and protein index, and so on, should be monitored in dogs with CDV. The treatment rate of CDV may be improved by adjusting the clinical medication at any time. Reduce mortality.
【學(xué)位授予單位】：河南科技大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：S858.292

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