本文選題：西門塔爾牛　切入點(diǎn)：親緣關(guān)系系數(shù)　出處：《畜牧獸醫(yī)學(xué)報(bào)》2016年02期 　論文類型：期刊論文

【摘要】：本研究旨在利用SNP標(biāo)記估計(jì)西門塔爾牛親緣關(guān)系系數(shù),以期準(zhǔn)確確定估計(jì)個(gè)體間親緣關(guān)系系數(shù)所需的SNPs數(shù)量。研究以1 059頭出生于2008-2012年的西門塔爾牛為試驗(yàn)群體,利用Illumina bovineHD(770k)芯片,根據(jù)最小等位基因頻率(MAF)區(qū)間,分別選擇100、500、1 000、1 500、2 000、2 500和3 000個(gè)SNPs用于個(gè)體間親緣關(guān)系系數(shù)的估計(jì)。結(jié)果顯示,隨著標(biāo)記數(shù)目的增多,估計(jì)的親緣關(guān)系系數(shù)準(zhǔn)確性逐漸增加。且當(dāng)SNP標(biāo)記數(shù)目達(dá)到2 500時(shí),所估計(jì)的親緣關(guān)系系數(shù)與利用所有標(biāo)記估計(jì)的個(gè)體間親緣關(guān)系系數(shù)差異不顯著,二者相關(guān)系數(shù)達(dá)到0.89以上。同時(shí),利用不同等位基因頻率區(qū)間內(nèi)標(biāo)記估計(jì)的個(gè)體間親緣關(guān)系系數(shù)差異不顯著。由此可以看出,當(dāng)所選標(biāo)記數(shù)目達(dá)到2 500以上時(shí),可以得到較高的親緣關(guān)系系數(shù)估計(jì)準(zhǔn)確性。本研究為基于SNP標(biāo)記信息估計(jì)親緣關(guān)系系數(shù)的進(jìn)一步研究提供了理論基礎(chǔ),同時(shí)為西門塔爾牛群體個(gè)體間親緣關(guān)系的研究提供依據(jù)。
[Abstract]:The purpose of this study was to estimate the genetic relationship coefficient of Simmental cattle by using SNP markers, in order to determine accurately the number of SNPs needed to estimate the genetic relationship coefficient among individuals. The study used 1 059 Simmental cattle born from 2008 to 2012 as the experimental population. Using Illumina bovine HDV 770k chip, according to the minimum allelic frequency (Maffs) interval, 100,500,000,000,000000 and 3,000 SNPs were selected to estimate the genetic relationship coefficient between individuals. The results showed that the number of markers increased with the increase of the number of markers. When the number of SNP markers reached 2 500, there was no significant difference between the estimated genetic coefficients and the estimated genetic coefficients among individuals using all markers. The correlation coefficient was above 0.89. At the same time, there was no significant difference in the coefficient of genetic relationship between individuals estimated by the markers in different allelic frequency intervals. It can be seen that when the number of markers selected is more than 2,500, This study provides a theoretical basis for the further study of estimating the genetic coefficients based on SNP markers and provides a basis for the study of the genetic relationship among individuals in Simmental cattle population.
【作者單位】： 吉林農(nóng)業(yè)大學(xué)動(dòng)物科技學(xué)院;中國農(nóng)業(yè)科學(xué)院北京畜牧獸醫(yī)研究所;
【基金】：國家自然科學(xué)基金(31402039) 北京市自然科學(xué)基金(6154032) 中國農(nóng)業(yè)科學(xué)院基本科研業(yè)務(wù)費(fèi)(2014ywf-yb-4) 農(nóng)業(yè)部物種資源保護(hù)(畜禽)項(xiàng)目(F557) 中國農(nóng)業(yè)科學(xué)院科技創(chuàng)新工程經(jīng)費(fèi)(cxgc-ias-03) 科技支撐計(jì)劃(2011BAD28B04) 863項(xiàng)目(2013AA102505-4) 中國農(nóng)業(yè)科學(xué)院院本級增量業(yè)務(wù)費(fèi)(2013ZL031)
【分類號】：S823

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