家禽天然免疫受體MDA5的作用和相關(guān)調(diào)控機(jī)制
發(fā)布時間:2018-02-23 22:29
本文關(guān)鍵詞: 黑色素瘤細(xì)胞 免疫受體 MDA 模式識別受體 β-干擾素 抗病毒免疫 Interferon 抗病毒天然免疫 結(jié)構(gòu)域 RNA 出處:《中國預(yù)防獸醫(yī)學(xué)報》2017年04期 論文類型:期刊論文
【摘要】:正黑色素瘤分化相關(guān)基因5(Melanoma differentiation associated gene-5,MDA5)最早在人黑色素瘤細(xì)胞中被發(fā)現(xiàn)~([1]),因其表達(dá)受到β-干擾素(IFN-β)轉(zhuǎn)錄的調(diào)控,又名IFIH1(Interferon induced with helicase C domain 1),也稱HELI-CARD和RH116。IFIH1基因編碼的MDA5蛋白屬于模式識別受體(Pattern recognition receptors,PRRs)中維甲酸基
[Abstract]:Melanoma differentiation associated gene-5MDA5) was first found in human melanoma cells because its expression is regulated by the transcription of 尾 -interferon (IFN- 尾). Also known as IFIH1(Interferon induced with helicase C domain 1, MDA5 proteins encoded by HELI-CARD and RH116.IFIH1 genes belong to retinoic acid groups in pattern recognition receptor pattern recognition receptors.
【作者單位】: 安徽農(nóng)業(yè)大學(xué)動物科技學(xué)院;
【基金】:國家自然科學(xué)基金(31101846)
【分類號】:S852.4
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本文編號:1527875
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