本文關鍵詞： 益生菌 腸上皮 先天免疫 免疫分子　出處：《中國畜牧獸醫(yī)》2017年12期 　論文類型：期刊論文

【摘要】：益生菌是可添加在飼料中對動物健康產(chǎn)生很多益處的活微生物,其在維持胃腸道微生物平衡、免疫調(diào)節(jié)和病原體防御中起關鍵作用,某些特定的益生菌菌株對加強腸上皮的完整性和調(diào)節(jié)一些免疫組分也顯示出一定程度的潛力。有關益生菌的作用機制是當前研究的熱點,其中,在益生菌調(diào)節(jié)腸道介導的防御反應的所有可能途徑中,腸屏障功能、先天和適應性黏膜免疫反應及信號傳導途徑被認為在針對病原菌的腸防御反應中起重要作用。作者主要針對益生菌如何與腸道內(nèi)的杯狀細胞黏蛋白、三葉因子(trefoil factors,tffs)、防御素、Toll樣受體(Toll-like receptors,TLRs)、分泌型免疫球蛋白A(secretory immunoglobulin A,sIgA)、熱休克蛋白(heat shock proteins,HSPs)和P-糖蛋白(P-glycoprotein,P-gp)相互作用而起到調(diào)節(jié)腸道先天防御反應的作用進行了概述,以期為今后研究益生菌對腸道健康及對感染病原體的腸道如何起到有益作用奠定基礎。
[Abstract]:Probiotics are living microorganisms that can be added to feed to produce many benefits to animal health. They play a key role in maintaining the balance of gastrointestinal microbes, immune regulation and pathogen defense. Some specific probiotic strains also show a certain degree of potential to enhance the integrity of intestinal epithelium and regulate some immune components. The mechanism of probiotics is the focus of current research. Intestinal barrier function in all possible pathways by which probiotics regulate gut mediated defense responses. Innate and adaptive mucosal immune responses and signal transduction pathways are thought to play an important role in gut defense responses to pathogens. The authors focus on how probiotics interact with goblet cell mucin in the gut. The trefoil factor is a trefoil factor, and the defensin Toll-like receptor is Toll-like receptor TLRs. Secretory immunoglobulin of secretory immunoglobulin of secretory shock proteins. The interaction between HSPs and P-glycoprotein P-gp (P-gp) was reviewed in this paper. In order to lay a foundation for the future study of probiotics on intestinal health and how to play a beneficial role in the intestinal tract of infected pathogens.
【作者單位】： 內(nèi)蒙古農(nóng)業(yè)大學獸醫(yī)學院;
【基金】：國家自然科學基金項目(31560682) 內(nèi)蒙古自然科學基金項目(2017MS0347)
【分類號】：S816.3
【正文快照】： 世界衛(wèi)生組織對益生菌的定義是:一類在攝入適當數(shù)量后會對宿主機體產(chǎn)生益處的活微生物。益生菌可作為飼料添加劑或微生物成分通過競爭性排斥(競爭結(jié)合位點、結(jié)合病原體、阻礙疾病內(nèi)化和競爭營養(yǎng)物)、直接頡頏作用(通過生產(chǎn)酸降低pH環(huán)境、分泌細菌素或細菌樣物質(zhì)、發(fā)揮解毒作用，

本文編號：1475825