發(fā)布時間：2019-03-08 10:22

【摘要】：本研究采用行為學(xué)和免疫組織化學(xué)等生物學(xué)技術(shù)，，探討外周5—羥色胺2A(5-HT_(2A)受體)在致炎物質(zhì)角叉菜膠(carrageenan)誘發(fā)的痛覺過敏和炎癥中的作用。 大鼠足趾部注射5-HT_(2A)受體拮抗劑酮色林(ketanserin)劑量依賴性地(0.5、3和5μg)抑制了角叉菜膠誘發(fā)的痛覺過敏、炎癥和脊髓腰4～5節(jié)段背角c-fos蛋白的表達(dá)。但是，5-HT_(1A)受體拮抗劑WAY-100635卻無此抑制作用。不同濃度(0.5％，1％和3％)的酮色林局部貼劑劑量依賴性地抑制了由高嶺土和角叉菜膠誘發(fā)的關(guān)節(jié)炎性疼痛和炎癥，而對非炎癥側(cè)沒有任何影響，表明這種作用是通過外周而不是中樞神經(jīng)系統(tǒng)。 本研究表明外周5—羥色胺參與一般慢性和關(guān)節(jié)炎中疼痛和炎癥的形成，而且這種作用是通過外周5—羥色胺2A受體介導(dǎo)的。
[Abstract]:The purpose of this study was to investigate the role of peripheral 5-hydroxytryptamine 2A (5-HT _ (2A) receptor) in hyperalgesia and inflammation induced by carrageenan (carrageenan) by means of behavioral and immunohistochemical techniques. A dose-dependent injection of 5-HT2A receptor antagonist ketelin (ketanserin) (0.5, 3 and 5 渭 g) inhibited carrageenan-induced hyperalgesia, inflammation and the expression of c-fos protein in the dorsal horn of the lumbar 4 and 5 segments of the spinal cord. However, 5-HT _ (1A) receptor antagonist WAY-100635 had no inhibitory effect. Different concentrations (0.5%, 1% and 3%) of ketoselin local patches dose-dependently inhibited inflammatory pain and inflammation in the joints induced by kaolin and carrageenan, but had no effect on the non-inflammatory side. This suggests that this effect is through the peripheral rather than central nervous system. This study suggests that peripheral serotonin is involved in the formation of pain and inflammation in general chronic and arthritis, and this effect is mediated by peripheral serotonin 2A receptor.
【學(xué)位授予單位】：福建師范大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2006
【分類號】：R363

【參考文獻(xiàn)】

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本文編號：2436709