發(fā)布時間：2018-07-26 21:05

【摘要】：B淋巴細(xì)胞刺激因子(B Lymphocyte Stimulator,BLyS)是1999年由瑞士和美國科學(xué)家發(fā)現(xiàn)的腫瘤壞死因子(Tumor Necrosis Factor,TNF)家族的一個新成員。該分子含有285個氨基酸,屬于Ⅱ型跨膜蛋白,編碼區(qū)位于染色體13q32-34。BLyS主要由T細(xì)胞和樹突狀細(xì)胞等髓系來源的細(xì)胞分泌。BLyS以膜結(jié)合以及可溶性兩種方式存在于機(jī)體中,兩者均具有生物學(xué)活性。 迄今為止,已經(jīng)發(fā)現(xiàn)了三種受體可以與BLyS結(jié)合,分別為BCMA、TACI和BAFF-R,由于缺少信號轉(zhuǎn)導(dǎo)序列,它們被劃歸為Ⅲ型膜蛋白。其中前兩者也可以與其他的分子結(jié)合,而BAFF-R則為BLyS特異性的受體,這些受體僅位于B細(xì)胞膜表面,使得BLyS的生物學(xué)活性——刺激B淋巴細(xì)胞的成熟以及增殖,有了高度的選擇性。 研究表明,BLyS在B細(xì)胞的存活和功能調(diào)節(jié)方面發(fā)揮著重要作用,它可以延長B細(xì)胞存活時間、促進(jìn)其增殖,從而導(dǎo)致B細(xì)胞增生和自身免疫狼瘡樣變化的出現(xiàn)。BLyS的過度表達(dá)是發(fā)生自身免疫性疾病,尤其是系統(tǒng)性紅斑狼瘡的重要因素之一。但是,對于BLyS的作用機(jī)制還不明了。
[Abstract]:B lymphocyte stimulating factor (B Lymphocyte timulatorus (BLyS) is a new member of the tumor necrosis factor (Tumor Necrosis) family discovered by scientists in Switzerland and the United States in 1999. The molecule contains 285 amino acids and belongs to type II transmembrane protein. The coding region is located in the chromosome 13q32-34.BLyS secreted mainly by myeloid cells such as T cells and dendritic cells. BLyS exists in the organism in two ways: membrane binding and soluble. Both have biological activity. Up to now, three receptors have been found to bind to BLyS, namely BCMA-TACI and BAFF-R.It is classified as type 鈪，

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