本文選題：凋亡 + 配體　； 參考：《山東大學(xué)》2005年博士論文

【摘要】：乙型肝炎病毒(HBV)是一個與肝炎、肝癌形成密切相關(guān)的致病因子,其致肝臟損傷以及細(xì)胞惡性變的機(jī)制迄今尚未完全闡明。乙肝病毒感染后所導(dǎo)致的機(jī)體免疫調(diào)節(jié)功能紊亂及肝細(xì)胞凋亡的失衡,是造成肝臟不同類型的病理變化及臨床轉(zhuǎn)歸的主要原因之一。探討HBV與機(jī)體免疫監(jiān)視分子的相互作用機(jī)制,對于進(jìn)一步理解HBV的致病機(jī)理和探索有效的治療方案有著重要意義,是一個十分有研究價值的問題。 TNF相關(guān)的凋亡誘導(dǎo)配體(TNF related apoptosis inducing ligand,TRAIL)、TNF相似的凋亡誘導(dǎo)分子(TNF-like weak inducer of apoptosis,TWEAK)是繼FasL之后發(fā)現(xiàn)的TNF家族中的新成員,具有其獨特的凋亡誘導(dǎo)特性。它們分布廣泛,對正常生理狀態(tài)下的機(jī)體組織沒有毒性,而只是在病理狀態(tài)下被激活來參與機(jī)體的免疫反應(yīng)。但是,作為機(jī)體的免疫監(jiān)視分子和免疫效應(yīng)分子,TRAIL、TWEAK是否參與了HBV的致病過程,及其在HBV相關(guān)疾病中的作用機(jī)制至今尚不清楚。我們率先開展了此項研究,并取得了一定的研究成果。 目的: 1.研究HBV轉(zhuǎn)染對TRAIL誘導(dǎo)細(xì)胞凋亡的影響及其機(jī)制。 2.研究IFN-γ/對TRAIL誘導(dǎo)HBV轉(zhuǎn)染細(xì)胞凋亡的影響,并初步探討其機(jī)制。 3.研究TRAIL-TRAIL受體系統(tǒng)在慢性乙肝患者外周血單個核細(xì)胞凋亡中的作用,探討它與臨床分期、肝臟損傷程度的關(guān)系。
[Abstract]:Hepatitis B virus (HBV) is a pathogenic factor closely related to the formation of hepatitis and liver cancer. The mechanism of liver injury and cell malignancy has not been fully elucidated up to now. The disorder of immune regulation and the imbalance of hepatocyte apoptosis caused by hepatitis B virus infection are one of the main reasons for the pathological changes and clinical outcome of the liver. It is of great significance to study the interaction mechanism between HBV and immune surveillance molecules, which is of great significance to further understand the pathogenesis of HBV and to explore an effective therapeutic scheme. TNF- like weak inducer of apoptosis induced molecule (TNF- like weak inducer of apoptosis induced by TNF- like ligand trail) is a very valuable problem. TNF- like weak inducer of apoptosis induced by TNF- like ligand (trail) is a kind of TNF-like weak inducer of apoptosis-inducing molecule (TWEAK). A new member of the TNF family, It has its unique apoptosis-inducing characteristics. They are widely distributed and are not toxic to normal physiological tissues, but are only activated in pathological state to participate in the immune response. However, whether the immune monitor molecule and the immune effector molecule Trail TWEAK are involved in the pathogenesis of HBV and its mechanism in HBV-related diseases are still unclear. We took the lead in this study and achieved some research results. Objective: 1. To study the effect of HBV transfection on trail induced apoptosis and its mechanism. 2. To study the effect of IFN- 緯 / 1 on trail induced apoptosis of HBV transfected cells and its mechanism. To investigate the role of trail receptor system in apoptosis of peripheral blood mononuclear cells (PBMC) in patients with chronic hepatitis B (CHB), and to explore the relationship between TRAIL-TRAIL receptor system and clinical stage and degree of liver injury.
【學(xué)位授予單位】：山東大學(xué)
【學(xué)位級別】：博士
【學(xué)位授予年份】：2005
【分類號】：R363

【引證文獻(xiàn)】

相關(guān)碩士學(xué)位論文 前1條

1 鄧蘭;腫瘤壞死因子凋亡相關(guān)配體（TRAIL）對乙肝病毒復(fù)制過程影響的初探[D];四川大學(xué);2007年

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本文編號：2087737